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Tprkb Gene Detail
Summary
  • Symbol
    Tprkb
  • Name
    Tp53rk binding protein
  • Synonyms
    0610033G21Rik, 1810034M08Rik, DRWMS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917036
    NCBI Gene: 69786
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85888847-85907266 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917036
protein coding gene Chr6:85888842-85907266 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030967
protein coding gene Chr6:87154821-87174557 (+)
A/J MGP_AJ_G0030933
protein coding gene Chr6:83801752-83819880 (+)
AKR/J MGP_AKRJ_G0030864
protein coding gene Chr6:86233480-86252617 (+)
BALB/cJ MGP_BALBcJ_G0030946
protein coding gene Chr6:83788172-83806295 (+)
C3H/HeJ MGP_C3HHeJ_G0030764
protein coding gene Chr6:98217632-98235718 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031403
protein coding gene Chr6:89525289-89543549 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028587
protein coding gene Chr6:81925399-81978421 (+)
CAST/EiJ MGP_CASTEiJ_G0030055
protein coding gene Chr6:86271147-86293090 (+)
CBA/J MGP_CBAJ_G0030630
protein coding gene Chr6:93042863-93065691 (+)
DBA/2J MGP_DBA2J_G0030786
protein coding gene Chr6:83122910-83140346 (+)
FVB/NJ MGP_FVBNJ_G0030739
protein coding gene Chr6:82297363-82314757 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0030772
protein coding gene Chr6:97201387-97221493 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031430
protein coding gene Chr6:86064538-86083202 (+)
PWK/PhJ MGP_PWKPhJ_G0029770
protein coding gene Chr6:82052644-82070896 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029598
protein coding gene Chr6:84909341-84931059 (+)
WSB/EiJ MGP_WSBEiJ_G0030136
protein coding gene Chr6:86512287-86531277 (+)



Homology
more
  • Human Ortholog
    TPRKB, TP53RK binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPRKB, TP53RK binding protein
  • Synonyms
    CGI121, CGI-121, GAMOS5
  • Links
    NCBI Gene ID: 51002
    neXtProt AC: NX_Q9Y3C4
    UniProt: Q9Y3C4

  • Chr Location
    2p13.1; chr2:73729104-73737400 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TPRKB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to E7.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054226 Ensembl Gene Model | MGI Sequence Detail 18420 C57BL/6J ±  kb
transcript ENSMUST00000200680 Ensembl | MGI Sequence Detail 814 Not Applicable  
polypeptide ENSMUSP00000144160 Ensembl | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    cDNA 61

    Microarray probesets 6
Other
Accession IDs
less
MGI:1922059
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory