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Tprkb Gene Detail
Summary
  • Symbol
    Tprkb
  • Name
    Tp53rk binding protein
  • Synonyms
    0610033G21Rik, 1810034M08Rik, DRWMS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917036
    NCBI Gene: 69786
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85911865-85930284 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917036
protein coding gene Chr6:85911759-85930284 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030967
protein coding gene Chr6:87154821-87174557 (+)
A/J MGP_AJ_G0030933
protein coding gene Chr6:83801752-83819880 (+)
AKR/J MGP_AKRJ_G0030864
protein coding gene Chr6:86233480-86252617 (+)
BALB/cJ MGP_BALBcJ_G0030946
protein coding gene Chr6:83788172-83806295 (+)
C3H/HeJ MGP_C3HHeJ_G0030764
protein coding gene Chr6:98217632-98235718 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031403
protein coding gene Chr6:89525289-89543549 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028587
protein coding gene Chr6:81925399-81978421 (+)
CAST/EiJ MGP_CASTEiJ_G0030055
protein coding gene Chr6:86271147-86293090 (+)
CBA/J MGP_CBAJ_G0030630
protein coding gene Chr6:93042863-93065691 (+)
DBA/2J MGP_DBA2J_G0030786
protein coding gene Chr6:83122910-83140346 (+)
FVB/NJ MGP_FVBNJ_G0030739
protein coding gene Chr6:82297363-82314757 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0030772
protein coding gene Chr6:97201387-97221493 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031430
protein coding gene Chr6:86064538-86083202 (+)
PWK/PhJ MGP_PWKPhJ_G0029770
protein coding gene Chr6:82052644-82070896 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029598
protein coding gene Chr6:84909341-84931059 (+)
WSB/EiJ MGP_WSBEiJ_G0030136
protein coding gene Chr6:86512287-86531277 (+)



Homology
more
  • Human Ortholog
    TPRKB, TP53RK binding protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TPRKB, TP53RK binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI121, CGI-121, GAMOS5
  • Links
    NCBI Gene ID: 51002
    neXtProt AC: NX_Q9Y3C4
    UniProt: Q9Y3C4

  • Chr Location
    2p13.1; chr2:73729830-73740133 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41096
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TPRKB
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TPRKB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054226 Ensembl Gene Model | MGI Sequence Detail 18420 C57BL/6J ±  kb
transcript ENSMUST00000200680 Ensembl | MGI Sequence Detail 814 Not Applicable  
polypeptide ENSMUSP00000144160 Ensembl | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    cDNA 61

    Microarray probesets 6
Other
Accession IDs
less
MGI:1922059
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:260067 Braun DA, et al., Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017 Oct;49(10):1529-1538

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory