Smap2 MGI Mouse Gene Detail - MGI:1917030

Symbol

Smap2
Name

small ArfGAP 2
Synonyms

1810031K02Rik, Smap1l, Smap2

Feature Type

protein coding gene
IDs

MGI:1917030
NCBI Gene: 69780
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr4:120825514-120874444 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 56.70 cM
Mapping Data

2 experiments

SNPs within 2kb

319 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917030	protein coding gene	Chr4:120825514-120874497 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028718	protein coding gene	Chr4:122268088-122316910 (-)
A/J	MGP_AJ_G0028678	protein coding gene	Chr4:117438737-117487364 (-)
AKR/J	MGP_AKRJ_G0028631	protein coding gene	Chr4:120028721-120081774 (-)
BALB/cJ	MGP_BALBcJ_G0028701	protein coding gene	Chr4:118053220-118102172 (-)
C3H/HeJ	MGP_C3HHeJ_G0028416	protein coding gene	Chr4:121556827-121606584 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029142	protein coding gene	Chr4:126874248-126923703 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026419	protein coding gene	Chr4:111484079-111532247 (-)
CAST/EiJ	MGP_CASTEiJ_G0027847	protein coding gene	Chr4:118929094-118979627 (-)
CBA/J	MGP_CBAJ_G0028383	protein coding gene	Chr4:130314526-130363349 (-)
DBA/2J	MGP_DBA2J_G0028530	protein coding gene	Chr4:118014964-118063851 (-)
FVB/NJ	MGP_FVBNJ_G0028496	protein coding gene	Chr4:116539530-116588302 (-)
LP/J	MGP_LPJ_G0028630	protein coding gene	Chr4:122390434-122439255 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028524	protein coding gene	Chr4:135120730-135170407 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029179	protein coding gene	Chr4:121105460-121154517 (-)
PWK/PhJ	MGP_PWKPhJ_G0027570	protein coding gene	Chr4:114964967-115015392 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027396	protein coding gene	Chr4:117522400-117573897 (-)
WSB/EiJ	MGP_WSBEiJ_G0027927	protein coding gene	Chr4:121119819-121168654 (-)

Human Ortholog

SMAP2, small ArfGAP2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SMAP2, small ArfGAP2
Synonyms

SMAP1L
Links

HGNC:25082

NCBI Gene ID: 64744

neXtProt AC: NX_Q8WU79

UniProt: Q8WU79
Chr Location

1p34.2; chr1:40344834-40423326 (+) GRCh38

MGI Vertebrate Homology

Smap2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SMAP2
Gene Tree

Smap2

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Smap2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility associated with globozoospermia, asthenozoospermia and abnormal acrosome formation.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

25
cDNA Data

76
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase smap2

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All Sequences

60
RefSeq

8
UniProt

4
CCDS

CCDS18598.1

Ensembl

ENSMUSG00000032870 (Evidence)
NCBI Gene

69780

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032870	Ensembl Gene Model \| MGI Sequence Detail	48931	C57BL/6J	± kb
transcript	ENSMUST00000043200	Ensembl \| MGI Sequence Detail	2905	Not Applicable
polypeptide	ENSMUSP00000035800	Ensembl \| MGI Sequence Detail	428	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015259 stromal membrane-associated protein 2

(term hierarchy)
InterPro Domains

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR001164 Arf GTPase activating protein

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All nucleic 77

cDNA 76

Primer pair 1

Microarray probesets 4

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MGI:2140133

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:226700 Sumiyoshi M, et al., Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. FEBS Lett. 2015 Sep 14;589(19 Pt B):2754-62

TSS for Smap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43184	Chr4:120874398-120874458 (-)	16 bp
Tssr43183	Chr4:120874344-120874396 (-)	74 bp
Tssr43182	Chr4:120874177-120874205 (-)	253 bp
Tssr43181	Chr4:120871816-120871837 (-)	2,617 bp
Tssr43180	Chr4:120865906-120865922 (-)	8,530 bp
Tssr43179	Chr4:120842485-120842500 (-)	31,951 bp
Tssr43178	Chr4:120842444-120842457 (-)	31,993 bp
Tssr43177	Chr4:120837286-120837299 (-)	37,151 bp
Tssr43176	Chr4:120832801-120832813 (-)	41,637 bp
Tssr43175	Chr4:120832716-120832781 (-)	41,695 bp
Tssr43174	Chr4:120832663-120832671 (-)	41,777 bp
Tssr43173	Chr4:120832639-120832662 (-)	41,793 bp
Tssr43172	Chr4:120832603-120832629 (-)	41,828 bp
Tssr43169	Chr4:120829309-120829322 (-)	45,128 bp
Tssr43168	Chr4:120826098-120826117 (-)	48,336 bp
Tssr43167	Chr4:120826022-120826054 (-)	48,406 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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