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Ttl Gene Detail
Summary
  • Symbol
    Ttl
  • Name
    tubulin tyrosine ligase
  • Synonyms
    2410003M22Rik, 2700049H19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916987
    NCBI Gene: 69737
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129065947-129096283 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.65 cM, cytoband F3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916987
protein coding gene Chr2:129065942-129096283 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026482
protein coding gene Chr2:132436525-132469069 (+)
A/J MGP_AJ_G0026446
protein coding gene Chr2:127071767-127102581 (+)
AKR/J MGP_AKRJ_G0026421
protein coding gene Chr2:130681399-130711569 (+)
BALB/cJ MGP_BALBcJ_G0026458
protein coding gene Chr2:127332481-127367369 (+)
C3H/HeJ MGP_C3HHeJ_G0026201
protein coding gene Chr2:131188440-131219598 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026903
protein coding gene Chr2:136578761-136611229 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024280
protein coding gene Chr2:121898590-121926523 (+)
CAST/EiJ MGP_CASTEiJ_G0025662
protein coding gene Chr2:131449181-131479226 (+)
CBA/J MGP_CBAJ_G0026181
protein coding gene Chr2:141627482-141663869 (+)
DBA/2J MGP_DBA2J_G0026315
protein coding gene Chr2:126461779-126492111 (+)
FVB/NJ MGP_FVBNJ_G0026279
protein coding gene Chr2:125111765-125141808 (+)
LP/J MGP_LPJ_G0026420
protein coding gene Chr2:132675684-132708022 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026299
protein coding gene Chr2:145544584-145575563 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026958
protein coding gene Chr2:130714345-130744574 (+)
PWK/PhJ MGP_PWKPhJ_G0025398
protein coding gene Chr2:126037255-126068734 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025200
protein coding gene Chr2:129825450-129855151 (+)
WSB/EiJ MGP_WSBEiJ_G0025736
protein coding gene Chr2:131635377-131666096 (+)



Homology
more
  • Human Ortholog
    TTL, tubulin tyrosine ligase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TTL, tubulin tyrosine ligase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 150465
    neXtProt AC: NX_Q8NG68
    UniProt: Q8NG68

  • Chr Location
    2q14.1; chr2:112482127-112532646 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32678
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TTL
  • Gene Tree
    Ttl
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality, impaired breathing, and fail to form the internal capsule in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69737 NCBI Gene Model | MGI Sequence Detail 30337 C57BL/6J ±  kb
    transcript NM_027192 RefSeq | MGI Sequence Detail 4562 C57BL/6  
    polypeptide P38585 UniProt | EBI | MGI Sequence Detail 377 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1922085, MGI:2139074
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:231929 Barnat M, et al., The GSK3-MAP1B pathway controls neurite branching and microtubule dynamics. Mol Cell Neurosci. 2016 Apr;72:9-21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory