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Card11
Gene Detail
Symbol

Name
ID
Card11
caspase recruitment domain family, member 11
MGI:1916978
Synonyms
0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
79.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:140872990-141000582 bp, - strand
From VEGA annotation of GRCm38

  127593 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CARD11
Gene Tree: Card11

Human
homologs
CARD11, caspase recruitment domain family, member 11
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84433
neXtProt AC: NX_Q9BXL7

Human Synonyms: BENTA, BIMP3, CARMA1, IMD11, PPBL

Human Chr (Location): 7p22; chr7:2906075-3043945 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CARD11

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(4) Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutation exhibit defects in antigen receptor signalling in both T and B lymphocytes.
 
Interactions
Card11 interacts with 85 markers (Mir22, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process positive regulation of B cell proliferation, positive regulation of cytokine production, ...
Component cytoplasm, extracellular exosome, ...
Function CARD domain binding, protein binding
External Resources: FuncBase
Expression
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN card11    NEW 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(11) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000054841 (Evidence)
Ensembl Gene Model ENSMUSG00000036526 (Evidence)
Entrez Gene 108723 (Evidence)
UniGene 46187
DFCI TC1585872, TC1681645, TC1698656
DoTS DT.110668386, DT.40137848, DT.60104704, DT.94127319
NIA Mouse Gene Index U026896
PDB 4I16
Consensus CDS Project CCDS51686.1
International Mouse Phenotyping Consortium Status Card11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054841 VEGA Gene Model | MGI Sequence Detail 127593 C57BL/6J ±  kb
transcript OTTMUST00000135887 VEGA | MGI Sequence Detail 4107 Not Applicable 
polypeptide OTTMUSP00000071829 VEGA | MGI Sequence Detail 1154 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(449 from dbSNP Build 137)    SNPs within 2kb including multiple locations(457)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 CARD domain
InterPro IPR011029 Death-like domain
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000005034 caspase recruitment domain-containing protein 11
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:223431 Daley SR, et al., Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-kappaB. J Exp Med. 2013 Feb 11;210(2):269-85
All references(73)
Other
accession IDs
MGI:1915575

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory