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Card11 Gene Detail
Summary
  • Symbol
    Card11
  • Name
    caspase recruitment domain family, member 11
  • Synonyms
    0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916978
    NCBI Gene: 108723
  • Gene Overview
    MyGene.info: CARD11
Location & Maps
more
  • Sequence Map
    Chr5:140872990-141000582 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      127593 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 79.42 cM
  • Mapping Data
    1 experiment
Homology
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  • Human Ortholog
    CARD11, caspase recruitment domain family member 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CARD11, caspase recruitment domain family member 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BENTA, BIMP3, CARMA1, IMD11, PPBL
  • Links
    NCBI Gene ID: 84433
    neXtProt AC: NX_Q9BXL7

  • Chr Location
    7p22; chr7:2906075-3043945 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human CARD11 associations

Human Disease Mouse Models
       B-Cell Expansion with NFKB and T-Cell Anergy; BENT   OMIM: 616452
Immunodeficiency 11; IMD11   OMIM: 615206
Persistent Polyclonal B-Cell Lymphocytosis; PPBL   OMIM: 606445
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 9 alleles in 9 genetic backgrounds
    1 phenotype from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    4
  • Gene trapped
    1
  • Targeted
    7
  • Incidental Mutations
Mice homozygous for a targeted null mutation exhibit defects in antigen receptor signalling in both T and B lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054841 VEGA Gene Model | MGI Sequence Detail 127593 C57BL/6J ±  kb
transcript OTTMUST00000135887 VEGA | MGI Sequence Detail 4107 Not Applicable  
polypeptide OTTMUSP00000071829 VEGA | MGI Sequence Detail 1154 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    437 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005034 caspase recruitment domain-containing protein 11
  • PDB
  • InterPro Domains
    IPR001315 CARD domain
    IPR033538 Caspase recruitment domain-containing protein 11
    IPR011029 Death-like domain
    IPR001478 PDZ domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 11
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1915575
References
more
  • Summaries
    All 72
    Gene Ontology 6
    Phenotypes 37
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:219718 Hara H, et al., Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-kappaB signalling. Nat Commun. 2015;6:5555

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory