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Card11 Gene Detail
Summary
  • Symbol
    Card11
  • Name
    caspase recruitment domain family, member 11
  • Synonyms
    0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916978
    NCBI Gene: 108723
  • Gene Overview
    MyGene.info: CARD11
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140872990-141000582 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 79.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    437 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916978
protein coding gene Chr5:140872990-141000596 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030308
protein coding gene Chr5:145997109-146135437 (-)
A/J MGP_AJ_G0030277
protein coding gene Chr5:139757846-139889240 (-)
AKR/J MGP_AKRJ_G0030209
protein coding gene Chr5:144116930-144254674 (-)
BALB/cJ MGP_BALBcJ_G0030294
protein coding gene Chr5:141005230-141135100 (-)
C3H/HeJ MGP_C3HHeJ_G0030005
protein coding gene Chr5:144930963-145067657 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030739
protein coding gene Chr5:151394880-151542404 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027957
protein coding gene Chr5:133587804-133719488 (-)
CAST/EiJ MGP_CASTEiJ_G0029410
protein coding gene Chr5:144353271-144491708 (-)
CBA/J MGP_CBAJ_G0029975
protein coding gene Chr5:157574839-157700537 (-)
DBA/2J MGP_DBA2J_G0030125
protein coding gene Chr5:139566141-139699188 (-)
FVB/NJ MGP_FVBNJ_G0030080
protein coding gene Chr5:138726192-138855835 (-)
LP/J MGP_LPJ_G0030211
protein coding gene Chr5:146599903-146739110 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030111
protein coding gene Chr5:160173242-160309906 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030779
protein coding gene Chr5:143961738-144093963 (-)
PWK/PhJ MGP_PWKPhJ_G0029125
protein coding gene Chr5:138592534-138724060 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028961
protein coding gene Chr5:141666558-141818906 (-)
WSB/EiJ MGP_WSBEiJ_G0029484
protein coding gene Chr5:144756886-144891160 (-)



Homology
more
  • Human Ortholog
    CARD11, caspase recruitment domain family member 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CARD11, caspase recruitment domain family member 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BENTA, BIMP3, CARMA1, IMD11, IMD11A, PPBL
  • Links
    NCBI Gene ID: 84433
    neXtProt AC: NX_Q9BXL7
    UniProt: Q9BXL7

  • Chr Location
    7p22.2; chr7:2906075-3043945 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 11 alleles in 11 genetic backgrounds
    15 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit defects in antigen receptor signalling in both T and B lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036526 Ensembl Gene Model | MGI Sequence Detail 127593 C57BL/6J ±  kb
transcript ENSMUST00000085786 Ensembl | MGI Sequence Detail 4107 Not Applicable  
polypeptide ENSMUSP00000082941 Ensembl | MGI Sequence Detail 1154 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 11
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915575
References
more
  • Summaries
    All 85
    Diseases 1
    Gene Ontology 7
    Phenotypes 42
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:235323 Letendre K, et al., Bringing statistics up to speed with data in analysis of lymphocyte motility. PLoS One. 2015;10(5):e0126333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory