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Card11
Gene Detail
Symbol

Name
ID
Card11
caspase recruitment domain family, member 11
MGI:1916978
Synonyms
0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
79.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:140872999-141000596 bp, - strand
From NCBI annotation of GRCm38

  127598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Card11

Human
homologs
Human Homolog CARD11, caspase recruitment domain family, member 11
NCBI Gene ID 84433
neXtProt AC  NX_Q9BXL7
Human Synonyms  BENTA, BIMP3, CARMA1, IMD11, PPBL
Human Chr (Location)  7p22; chr7:2906075-3043945 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CARD11
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(3) Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit defects in antigen receptor signalling in both T and B lymphocytes.
 
Interactions
Card11 interacts with 85 markers (Mir22, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(11) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000036526 (Evidence)
Entrez Gene108723 (Evidence)
UniGene46187
DFCITC1585872, TC1698656, TC1681645
DoTSDT.60104704, DT.94127319, DT.110668386, DT.40137848
NIA Mouse Gene IndexU026896
PDB4I16
Consensus CDS ProjectCCDS51686.1
International Mouse Knockout Project StatusCard11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 108723 NCBI Gene Model | MGI Sequence Detail 127598 C57BL/6J ±  kb
transcript NM_175362 RefSeq | MGI Sequence Detail 4112 Not Specified 
polypeptide Q8CIS0 UniProt | EBI | MGI Sequence Detail 1159 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(449 from dbSNP Build 137)    SNPs within 2kb including multiple locations(457)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000005034 caspase recruitment domain-containing protein 11
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208208 Rajasekaran K, et al., Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. Nat Immunol. 2013 Nov;14(11):1127-36
All references(71)
Other
accession IDs
MGI:1915575

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory