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Usp46
Gene Detail
 Symbol
Name
ID
Usp46
ubiquitin specific peptidase 46
MGI:1916977
Synonyms 1190009E20Rik, 2410018I08Rik
Feature Type protein coding gene
Genetic Map
Chromosome 5
39.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:73998463-74068430 bp, - strand
From VEGA annotation of GRCm38

  69968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Usp46

Human
homologs
Human Homolog USP46, ubiquitin specific peptidase 46
NCBI Gene ID 64854
neXtProt AC  NX_P62068
Human Chr (Location)  4q12; chr4:52590960-52659335 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(86) : Gene trapped(83) QTL(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit reduced depression-related behaviors.
 
Interactions
Usp46 interacts with 365 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process adult feeding behavior, behavior, ...
Component cellular_component
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 1
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000026338 (Evidence)
Ensembl Gene ModelENSMUSG00000054814 (Evidence)
Entrez Gene69727 (Evidence)
DFCITC1577456, TC1643796
DoTSDT.101125744, DT.101390001, DT.40169254, DT.529250
NIA Mouse Gene IndexU026301
EC3.4.19.12
Consensus CDS ProjectCCDS39112.1
International Mouse Knockout Project StatusUsp46
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026338 VEGA Gene Model | MGI Sequence Detail 69968 C57BL/6J ±  kb
transcript OTTMUST00000065130 VEGA | MGI Sequence Detail 4636 Not Applicable 
polypeptide OTTMUSP00000032420 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(624 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology PR:000017185 ubiquitin carboxyl-terminal hydrolase 46
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:199846 Imai S, et al., Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice. PLoS One. 2013;8(3):e58566
All references(39)
Other
accession IDs
MGI:1916152, MGI:2140899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory