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Usp46 Gene Detail
Summary
  • Symbol
    Usp46
  • Name
    ubiquitin specific peptidase 46
  • Synonyms
    1190009E20Rik, 2410018I08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916977
    NCBI Gene: 69727
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73998726-74068411 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 39.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    611 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916977
protein coding gene Chr5:73998453-74068431 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029630
protein coding gene Chr5:74033377-74116609 (-)
A/J MGP_AJ_G0029598
protein coding gene Chr5:71253767-71324992 (-)
AKR/J MGP_AKRJ_G0029546
protein coding gene Chr5:73563360-73649124 (-)
BALB/cJ MGP_BALBcJ_G0029607
protein coding gene Chr5:71963640-72034040 (-)
C3H/HeJ MGP_C3HHeJ_G0029330
protein coding gene Chr5:73958108-74033022 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030061
protein coding gene Chr5:77064926-77134603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027301
protein coding gene Chr5:66922459-66989864 (-)
CAST/EiJ MGP_CASTEiJ_G0028738
protein coding gene Chr5:73027121-73111187 (-)
CBA/J MGP_CBAJ_G0029299
protein coding gene Chr5:79584455-79669989 (-)
DBA/2J MGP_DBA2J_G0029444
protein coding gene Chr5:71323405-71395211 (-)
FVB/NJ MGP_FVBNJ_G0029405
protein coding gene Chr5:70470527-70544844 (-)
LP/J MGP_LPJ_G0029530
protein coding gene Chr5:74477629-74557179 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029432
protein coding gene Chr5:82873541-82947075 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030094
protein coding gene Chr5:73100289-73181354 (-)
PWK/PhJ MGP_PWKPhJ_G0028461
protein coding gene Chr5:70296242-70369968 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028296
protein coding gene Chr5:72455933-72531896 (-)
WSB/EiJ MGP_WSBEiJ_G0028818
protein coding gene Chr5:73399863-73478004 (-)



Homology
more
  • Human Ortholog
    USP46, ubiquitin specific peptidase 46
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP46, ubiquitin specific peptidase 46
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 64854
    neXtProt AC: NX_P62068
    UniProt: P62068

  • Chr Location
    4q12; chr4:52590960-52659335 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56957
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: USP46
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    264 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced depression-related behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69727 NCBI Gene Model | MGI Sequence Detail 69686 C57BL/6J ±  kb
transcript NM_177561 RefSeq | MGI Sequence Detail 3225 C57BL/6  
polypeptide P62069 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 5
Other
Accession IDs
less
MGI:1916152, MGI:2140899
References
more
  • Summaries
    All 292
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 10
    Phenotypes 264
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:266037 Jain S, et al., Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E357-E366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory