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Usp46
Gene Detail
Symbol

Name
ID
Usp46
ubiquitin specific peptidase 46
MGI:1916977
Synonyms
1190009E20Rik, 2410018I08Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
39.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:73998463-74068430 bp, - strand
From VEGA annotation of GRCm38

  69968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: USP46
Gene Tree: Usp46

Human
homologs
USP46, ubiquitin specific peptidase 46
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64854
neXtProt AC: NX_P62068

Human Chr (Location): 4q12; chr4:52590960-52659335 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(87) : Gene trapped(83) QTL(2) Radiation induced(1) Targeted(1)
Genomic Mutations involving Usp46 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele exhibit reduced depression-related behaviors.
 
Phenotype Images(4)
Interactions
Usp46 interacts with 365 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process adult feeding behavior, behavior, ...
Component cellular_component
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase usp46    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000026338 (Evidence)
Ensembl Gene Model ENSMUSG00000054814 (Evidence)
Entrez Gene 69727 (Evidence)
DFCI TC1643796, TC1577456
DoTS DT.101390001, DT.529250, DT.101125744, DT.40169254
NIA Mouse Gene Index U026301
EC 3.4.19.12
Consensus CDS Project CCDS39112.1
International Mouse Phenotyping Consortium Status Usp46
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026338 VEGA Gene Model | MGI Sequence Detail 69968 C57BL/6J ±  kb
transcript OTTMUST00000065130 VEGA | MGI Sequence Detail 4636 Not Applicable 
polypeptide OTTMUSP00000032420 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(624 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology PR:000017185 ubiquitin carboxyl-terminal hydrolase 46
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:199846 Imai S, et al., Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice. PLoS One. 2013;8(3):e58566
All references(38)
Other
accession IDs
MGI:1916152, MGI:2140899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory