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Usp46 Gene Detail
Summary
  • Symbol
    Usp46
  • Name
    ubiquitin specific peptidase 46
  • Synonyms
    1190009E20Rik, 2410018I08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916977
    NCBI Gene: 69727
Location & Maps
more
  • Sequence Map
    Chr5:73998453-74068431 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69979 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 39.33 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    USP46, ubiquitin specific peptidase 46
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP46, ubiquitin specific peptidase 46
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 64854
    neXtProt AC: NX_P62068

  • Chr Location
    4q12; chr4:52590960-52659335 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56957
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: USP46
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    235 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    90
  • Chemically induced (other)
    2
  • Gene trapped
    81
  • QTL
    2
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    1
  • Genomic Mutations
    6 involving Usp46
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit reduced depression-related behaviors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026338 VEGA Gene Model | MGI Sequence Detail 69979 C57BL/6J ±  kb
transcript OTTMUST00000065130 VEGA | MGI Sequence Detail 4557 Not Applicable  
polypeptide OTTMUSP00000032420 VEGA | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    617 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017185 ubiquitin carboxyl-terminal hydrolase 46
  • EC
  • InterPro Domains
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 5
Other
Accession IDs
less
MGI:1916152, MGI:2140899
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 235
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:199846 Imai S, et al., Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice. PLoS One. 2013;8(3):e58566

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory