Rpain MGI Mouse Gene Detail - MGI:1916973

Symbol

Rpain
Name

RPA interacting protein
Synonyms

2400006N03Rik

Feature Type

protein coding gene
IDs

MGI:1916973
NCBI Gene: 69723
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:70861039-70868659 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.21 cM, cytoband B4
Mapping Data

2 experiments

SNPs within 2kb

52 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916973	protein coding gene	Chr11:70860403-70868759 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018619	protein coding gene	Chr11:71544487-71553319 (+)
A/J	MGP_AJ_G0018587	protein coding gene	Chr11:68826217-68833837 (+)
AKR/J	MGP_AKRJ_G0018556	protein coding gene	Chr11:70900692-70908313 (+)
BALB/cJ	MGP_BALBcJ_G0018559	protein coding gene	Chr11:69136455-69144076 (+)
C3H/HeJ	MGP_C3HHeJ_G0018372	protein coding gene	Chr11:70928540-70936161 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019010	protein coding gene	Chr11:73713846-73721466 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016655	protein coding gene	Chr11:65731138-65739251 (+)
CAST/EiJ	MGP_CASTEiJ_G0017927	protein coding gene	Chr11:71205401-71214723 (+)
CBA/J	MGP_CBAJ_G0018344	protein coding gene	Chr11:77034337-77041958 (+)
DBA/2J	MGP_DBA2J_G0018454	protein coding gene	Chr11:68406123-68413749 (+)
FVB/NJ	MGP_FVBNJ_G0018444	protein coding gene	Chr11:68049348-68056973 (+)
LP/J	MGP_LPJ_G0018524	protein coding gene	Chr11:72124220-72133494 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018467	protein coding gene	Chr11:77575578-77583199 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019052	protein coding gene	Chr11:71158580-71166201 (+)
PWK/PhJ	MGP_PWKPhJ_G0017701	protein coding gene	Chr11:69057685-69068022 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017491	protein coding gene	Chr11:70967296-70975499 (+)
WSB/EiJ	MGP_WSBEiJ_G0017981	protein coding gene	Chr11:70821873-70829495 (+)

Human Ortholog

RPAIN, RPA interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPAIN, RPA interacting protein
Synonyms

HRIP, RIP
Links

HGNC:28641

NCBI Gene ID: 84268

neXtProt AC: NX_Q86UA6

UniProt: Q86UA6
Chr Location

17p13.2; chr17:5419641-5432877 (+) GRCh38

MGI Vertebrate Homology

Rpain stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPAIN
Gene Tree

Rpain

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Genomic Mutations

2 involving Rpain
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation and decreased trophectoderm cell proliferation during outgrowth culture.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

14
cDNA Data

35
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpain

ZFIN rpain

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All Sequences

70
RefSeq

10
UniProt

9
CCDS

CCDS24969.1, CCDS56790.1, CCDS56791.1, CCDS56792.1

Ensembl

ENSMUSG00000018449 (Evidence)
NCBI Gene

69723

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018449	Ensembl Gene Model \| MGI Sequence Detail	7621	C57BL/6J	± kb
transcript	ENSMUST00000018593	Ensembl \| MGI Sequence Detail	1100	Not Applicable
polypeptide	ENSMUSP00000018593	Ensembl \| MGI Sequence Detail	219	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000014174 RPA-interacting protein

(term hierarchy)
InterPro Domains

IPR028156 RPA-interacting protein

IPR028155 RPA-interacting protein, central domain

IPR028159 RPA-interacting protein, C-terminal domain

IPR028158 RPA-interacting protein, N-terminal domain

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All nucleic 36

cDNA 35

Primer pair 1

Microarray probesets 4

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Rpain:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102803	Chr11:70861007-70861022 (+)	-24 bp
Tssr102804	Chr11:70861293-70861343 (+)	279 bp
Tssr102805	Chr11:70861977-70861988 (+)	944 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23