Cad Gene Detail

Summary

• Symbol
  Cad
• Name
  carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
• Synonyms
  2410008J01Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1916969
  NCBI Gene: 69719
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr5:31054780-31078479 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    23700 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 16.95 cM, cytoband B1
• Mapping Data
  4 experiments

Homology

• Human Ortholog
  CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

• Vertebrate Orthologs
  10

• Human Ortholog
  CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  Orthology source: HomoloGene, HGNC
• Synonyms
  CDG1Z, EIEE50, GATD4
• Links
  HGNC:1424

  NCBI Gene ID: 790

  neXtProt AC: NX_P27708

  UniProt: P27708

  
  
• Chr Location
  2p23.3; chr2:27217257-27243792 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 1412
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: CAD
• Gene Tree
  Cad
  

Human Diseases

• Diseases
  1 with human CAD associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation type I IDs congenital disorder of glycosylation type I       DOID:0050570 OMIM:212065 OMIM:300884 OMIM:300934 OMIM:601110 OMIM:602579 OMIM:603147 OMIM:607143 OMIM:607906 OMIM:608093 OMIM:608104 OMIM:608540 OMIM:608776 OMIM:608799 OMIM:609180 OMIM:610768 OMIM:612015 OMIM:612379 OMIM:612937 OMIM:613661 OMIM:614507 OMIM:614921 OMIM:615042 OMIM:615596 OMIM:615597 OMIM:616457

Click on a disease name to see all genes associated with that disease.

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  26 phenotype references
  

• All Mutations and Alleles
  14
• Chemically induced (other)
  2
• Gene trapped
  7
• Radiation induced
  2
• Spontaneous
  1
• Targeted
  2
• Genomic Mutations
  5 involving Cad
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  42 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  61
• GO References
  6

• External Resources
  FuncBase

Expression

• Assay Results
  106
• Tissues
  102
• cDNA Data
  231
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase cad
  ZFIN cad

Interactions

• Cad interacts with 91 markers (Mir15a, Mir15b, Mir16-1, ...) View All

Sequences &
Gene Models

• All Sequences
  80
• RefSeq
  10
• UniProt
  10
• CCDS
  CCDS19171.1, CCDS80245.1, CCDS80246.1
• UniGene
  305535

• VEGA
  OTTMUSG00000022393 (Evidence)
• Ensembl
  ENSMUSG00000013629 (Evidence)
• NCBI Gene
  69719

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000022393	VEGA Gene Model | MGI Sequence Detail	23700	C57BL/6J
transcript	OTTMUST00000053506	VEGA | MGI Sequence Detail	7137	Not Applicable
polypeptide	OTTMUSP00000025444	VEGA | MGI Sequence Detail	2225	Not Applicable

Polymorphisms

• SNPs within 2kb
  133 from dbSNP Build 142

Protein
Information

• UniProt
  10 Sequences
• Protein Ontology
  PR:000004959 CAD protein
  (term hierarchy)
• EC
  2.1.3.2, 3.5.2.3, 6.3.5.5
• InterPro Domains
  IPR006680 Amidohydrolase-related
  IPR002082 Aspartate carbamoyltransferase
  IPR006130 Aspartate/ornithine carbamoyltransferase
  IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
  IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
  IPR036901 Aspartate/ornithine carbamoyltransferase superfamily
  IPR011761 ATP-grasp fold
  IPR013815 ATP-grasp fold, subdomain 1
  IPR006275 Carbamoyl-phosphate synthase, large subunit
  IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
  IPR006274 Carbamoyl-phosphate synthase, small subunit
  IPR035686 Carbamoyl-phosphate synthase small subunit, GATase1 domain
  IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domain
  IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily
  IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
  IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
  IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily
  IPR029062 Class I glutamine amidotransferase-like
  IPR002195 Dihydroorotase, conserved site
  IPR017926 Glutamine amidotransferase
  IPR032466 Metal-dependent hydrolase
  IPR011059 Metal-dependent hydrolase, composite domain superfamily
  IPR011607 Methylglyoxal synthase-like domain
  IPR036914 Methylglyoxal synthase-like domain superfamily
  IPR016185 Pre-ATP-grasp domain superfamily

Molecular
Reagents

• All nucleic 234

  Genomic 1

  cDNA 231

  Primer pair 2

  
  

  Microarray probesets 7

Other
Accession IDs

MGI:2141042

References

• Summaries
  All 58

  Developmental Gene Expression 2

  Diseases 1

  Gene Ontology 6

  Phenotypes 26
• Earliest
  J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
• Latest
  J:259377 Gao L, et al., Novel role for caspase-activated DNase in the regulation of pathological cardiac hypertrophy. Hypertension. 2015 Apr;65(4):871-81