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Cad Gene Detail
Summary
  • Symbol
    Cad
  • Name
    carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • Synonyms
    2410008J01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916969
    NCBI Gene: 69719
Location & Maps
more
  • Sequence Map
    Chr5:31054780-31078479 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23700 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 16.95 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDG1Z
  • Links
    NCBI Gene ID: 790
    neXtProt AC: NX_P27708

  • Chr Location
    2p22-p21; chr2:27217390-27243792 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1412
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CAD
  • Gene Tree
    Cad
Human Diseases
more
  • Diseases
    1 with human CAD associations

Human Disease Mouse Models
       Congenital Disorder of Glycosylation, Type Iz; CDG1Z   OMIM: 616457
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Gene trapped
    7
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    6 involving Cad
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022393 VEGA Gene Model | MGI Sequence Detail 23700 C57BL/6J ±  kb
transcript OTTMUST00000053506 VEGA | MGI Sequence Detail 7137 Not Applicable  
polypeptide OTTMUSP00000025444 VEGA | MGI Sequence Detail 2225 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    133 from dbSNP Build 142
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000004959 CAD protein
  • EC
  • InterPro Domains
    IPR006680 Amidohydrolase-related
    IPR002082 Aspartate carbamoyltransferase
    IPR006130 Aspartate/ornithine carbamoyltransferase
    IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
    IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
    IPR011761 ATP-grasp fold
    IPR013815 ATP-grasp fold, subdomain 1
    IPR013816 ATP-grasp fold, subdomain 2
    IPR006275 Carbamoyl-phosphate synthase, large subunit
    IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
    IPR006274 Carbamoyl-phosphate synthase, small subunit
    IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain
    IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
    IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
    IPR029062 Class I glutamine amidotransferase-like
    IPR002195 Dihydroorotase, conserved site
    IPR017926 Glutamine amidotransferase
    IPR032466 Metal-dependent hydrolase
    IPR011059 Metal-dependent hydrolase, composite domain
    IPR011607 Methylglyoxal synthase-like domain
    IPR016185 Pre-ATP-grasp domain
Molecular
Reagents
less
  • All nucleic 234
    Genomic 1
    cDNA 231
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:2141042
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:84769 Boyd KE, et al., c-Myc target gene specificity is determined by a post-DNAbinding mechanism. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13887-92
  • Latest
    J:187427 Rainger J, et al., Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. Hum Mol Genet. 2012 Sep 15;21(18):3969-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory