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Cad Gene Detail
Summary
  • Symbol
    Cad
  • Name
    carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • Synonyms
    2410008J01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916969
    NCBI Gene: 69719
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31054780-31078479 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 16.95 cM, cytoband B1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916969
protein coding gene Chr5:31054620-31078479 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029407
protein coding gene Chr5:29024215-29051280 (+)
A/J MGP_AJ_G0029373
protein coding gene Chr5:28080069-28104824 (+)
AKR/J MGP_AKRJ_G0029324
protein coding gene Chr5:29231354-29255384 (+)
BALB/cJ MGP_BALBcJ_G0029384
protein coding gene Chr5:28597472-28622096 (+)
C3H/HeJ MGP_C3HHeJ_G0029105
protein coding gene Chr5:29244266-29268256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029837
protein coding gene Chr5:30817218-30841818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027075
protein coding gene Chr5:25549970-25573008 (+)
CAST/EiJ MGP_CASTEiJ_G0028515
protein coding gene Chr5:28329386-28353126 (+)
CBA/J MGP_CBAJ_G0029073
protein coding gene Chr5:31391957-31419182 (+)
DBA/2J MGP_DBA2J_G0029222
protein coding gene Chr5:28258170-28281930 (+)
FVB/NJ MGP_FVBNJ_G0029180
protein coding gene Chr5:27675906-27699954 (+)
LP/J MGP_LPJ_G0029307
protein coding gene Chr5:29485247-29510490 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029209
protein coding gene Chr5:32270250-32295865 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029871
protein coding gene Chr5:28738587-28762116 (+)
PWK/PhJ MGP_PWKPhJ_G0028240
protein coding gene Chr5:27380320-27405322 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028070
protein coding gene Chr5:28111500-28139546 (+)
WSB/EiJ MGP_WSBEiJ_G0028596
protein coding gene Chr5:28803801-28829416 (+)



Homology
more
  • Human Ortholog
    CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDG1Z, DEE50, EIEE50, GATD4
  • Links
    NCBI Gene ID: 790
    neXtProt AC: NX_P27708
    UniProt: P27708

  • Chr Location
    2p23.3; chr2:27217257-27243792 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1412
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CAD
  • Gene Tree
    Cad
Human Diseases
more
  • Diseases
    1 with human CAD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013629 Ensembl Gene Model | MGI Sequence Detail 23700 C57BL/6J ±  kb
    transcript ENSMUST00000013773 Ensembl | MGI Sequence Detail 7137 Not Applicable  
    polypeptide ENSMUSP00000013773 Ensembl | MGI Sequence Detail 2225 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000004959 CAD protein
    • EC
    • InterPro Domains
      IPR006680 Amidohydrolase-related
      IPR002082 Aspartate carbamoyltransferase
      IPR006130 Aspartate/ornithine carbamoyltransferase
      IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
      IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
      IPR036901 Aspartate/ornithine carbamoyltransferase superfamily
      IPR011761 ATP-grasp fold
      IPR013815 ATP-grasp fold, subdomain 1
      IPR006275 Carbamoyl-phosphate synthase, large subunit
      IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
      IPR006274 Carbamoyl-phosphate synthase, small subunit
      IPR035686 Carbamoyl-phosphate synthase small subunit, GATase1 domain
      IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domain
      IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily
      IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
      IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
      IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily
      IPR029062 Class I glutamine amidotransferase-like
      IPR002195 Dihydroorotase, conserved site
      IPR017926 Glutamine amidotransferase
      IPR032466 Metal-dependent hydrolase
      IPR011059 Metal-dependent hydrolase, composite domain superfamily
      IPR011607 Methylglyoxal synthase-like domain
      IPR036914 Methylglyoxal synthase-like domain superfamily
      IPR016185 Pre-ATP-grasp domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 235
      Genomic 1
      cDNA 232
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2141042
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:267654 Saul MC, et al., Genomic variants in an inbred mouse model predict mania-like behaviors. PLoS One. 2018;13(5):e0197624

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    01/19/2021
    MGI 6.16
    The Jackson Laboratory