Cad MGI Mouse Gene Detail - MGI:1916969 - carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Cad Gene Detail

Symbol

Cad
Name

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms

2410008J01Rik

Feature Type

protein coding gene
IDs

MGI:1916969
NCBI Gene: 69719
Alliance

gene page

Sequence Map

Chr5:31054780-31078479 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

23700 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 16.95 cM, cytoband B1
Mapping Data

4 experiments

Human Ortholog

CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Vertebrate Orthologs

10

Human Ortholog

CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Orthology source: HomoloGene, HGNC
Synonyms

CDG1Z, EIEE50, GATD4
Links

HGNC:1424

NCBI Gene ID: 790

neXtProt AC: NX_P27708

UniProt: P27708
Chr Location

2p23.3; chr2:27217257-27243792 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1412
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CAD
Gene Tree

Cad

Diseases

1 with human CAD associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation type I IDs congenital disorder of glycosylation type I DOID:0050570 OMIM:212065 OMIM:300884 OMIM:300934 OMIM:601110 OMIM:602579 OMIM:603147 OMIM:607143 OMIM:607906 OMIM:608093 OMIM:608104 OMIM:608540 OMIM:608776 OMIM:608799 OMIM:609180 OMIM:610768 OMIM:612015 OMIM:612379 OMIM:612937 OMIM:613661 OMIM:614507 OMIM:614921 OMIM:615042 OMIM:615596 OMIM:615597 OMIM:616457

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

26 phenotype references

All Mutations and Alleles

15
Chemically induced (other)

2
Gene trapped

7
Radiation induced

3
Spontaneous

1
Targeted

2
Genomic Mutations

6 involving Cad
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available

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All GO Annotations

63
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

106
Tissues

102
cDNA Data

231
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN cad

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Cad interacts with 91 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

80
RefSeq

10
UniProt

10
CCDS

CCDS19171.1, CCDS80245.1, CCDS80246.1
UniGene

305535

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022393	VEGA Gene Model \| MGI Sequence Detail	23700	C57BL/6J	± kb
transcript	OTTMUST00000053506	VEGA \| MGI Sequence Detail	7137	Not Applicable
polypeptide	OTTMUSP00000025444	VEGA \| MGI Sequence Detail	2225	Not Applicable

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SNPs within 2kb

133 from dbSNP Build 142

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UniProt

10 Sequences
Protein Ontology

PR:000004959 CAD protein

(term hierarchy)
EC

2.1.3.2, 3.5.2.3, 6.3.5.5
InterPro Domains

IPR006680 Amidohydrolase-related

IPR002082 Aspartate carbamoyltransferase

IPR006130 Aspartate/ornithine carbamoyltransferase

IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain

IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding

IPR011761 ATP-grasp fold

IPR013815 ATP-grasp fold, subdomain 1

IPR006275 Carbamoyl-phosphate synthase, large subunit

IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain

IPR006274 Carbamoyl-phosphate synthase, small subunit

IPR035686 Carbamoyl-phosphate synthase small subunit, GATase1 domain

IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domain

IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain

IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

IPR029062 Class I glutamine amidotransferase-like

IPR002195 Dihydroorotase, conserved site

IPR017926 Glutamine amidotransferase

IPR032466 Metal-dependent hydrolase

IPR011059 Metal-dependent hydrolase, composite domain superfamily

IPR011607 Methylglyoxal synthase-like domain

IPR016185 Pre-ATP-grasp domain superfamily

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All nucleic 234

Genomic 1

cDNA 231

Primer pair 2

Microarray probesets 7

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MGI:2141042

Summaries

All 56

Developmental Gene Expression 2

Diseases 1

Gene Ontology 6

Phenotypes 26
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:237754 Maga AM, et al., Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico. Front Physiol. 2015;6:92

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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