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Trip13 Gene Detail
Summary
  • Symbol
    Trip13
  • Name
    thyroid hormone receptor interactor 13
  • Synonyms
    2410002G23Rik, D13Ertd328e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916966
    NCBI Gene: 69716
  • Gene Overview
    MyGene.info: TRIP13
Location & Maps
more
  • Sequence Map
    Chr13:73911347-73937767 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26421 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM, cytoband C1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TRIP13, thyroid hormone receptor interactor 13
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRIP13, thyroid hormone receptor interactor 13
    Orthology source: HGNC, HomoloGene
  • Synonyms
    16E1BP
  • Links
    NCBI Gene ID: 9319
    neXtProt AC: NX_Q15645

  • Chr Location
    5p15.33; chr5:892854-919072 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 2 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    14
  • Targeted
    4
  • Genomic Mutations
    1 involving Trip13
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit postnatal lethality, infertility, reduced gonad size, tail defects and meiotic arrest of sperm and oocytes associated with unrepaired double strand breaks.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054943 VEGA Gene Model | MGI Sequence Detail 26421 C57BL/6J ±  kb
transcript OTTMUST00000136177 VEGA | MGI Sequence Detail 3382 Not Applicable  
polypeptide OTTMUSP00000071946 VEGA | MGI Sequence Detail 432 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    157 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016672 thyroid receptor-interacting protein 13
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003960 ATPase, AAA-type, conserved site
    IPR003959 ATPase, AAA-type, core
    IPR001270 ClpA/B family
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 15
    cDNA 11
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGI:1196282
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:224234 Pacheco S, et al., The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes. PLoS Genet. 2015 Mar;11(3):e1005017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory