Trip13 MGI Mouse Gene Detail - MGI:1916966 - thyroid hormone receptor interactor 13

Symbol

Trip13
Name

thyroid hormone receptor interactor 13
Synonyms

2410002G23Rik, D13Ertd328e

Feature Type

protein coding gene
IDs

MGI:1916966
NCBI Gene: 69716
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:74060577-74085855 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 40.15 cM, cytoband C1
Mapping Data

4 experiments

SNPs within 2kb

653 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916966	protein coding gene	Chr13:74059466-74085903 (-)
129S1/SvImJ	ENSMUSG00200010720	protein coding gene	Chr13:68450803-68477246 (-)
A/J	ENSMUSG00195028135	protein coding gene	Chr13:69038876-69065323 (-)
AKR/J	ENSMUSG00220036267	protein coding gene	Chr13:67628741-67655091 (-)
BALB/cJ	ENSMUSG00180020991	protein coding gene	Chr13:69537251-69563690 (-)
C3H/HeJ	ENSMUSG00175007872	protein coding gene	Chr13:69814290-69840639 (-)
C57BL/6NJ	ENSMUSG00215009907	protein coding gene	Chr13:69603219-69629658 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018710	protein coding gene	Chr13:68560993-68584936 (-)
CAST/EiJ	ENSTCUG00005011462	protein coding gene	Chr13:69119261-69145610 (-)
CBA/J	ENSMUSG00210008631	protein coding gene	Chr13:69138559-69164998 (-)
DBA/2J	ENSMUSG00185017619	protein coding gene	Chr13:72830095-72856534 (-)
FVB/NJ	ENSMUSG00205023229	protein coding gene	Chr13:68517455-68543897 (-)
JF1/MsJ	ENSUMUG00000024637	protein coding gene	Chr13:72589908-72616257 (-)
LP/J	ENSMUSG00230025086	protein coding gene	Chr13:82748898-82775344 (-)
NOD/ShiLtJ	ENSMUSG00190028428	protein coding gene	Chr13:69137885-69164361 (-)
NZO/HlLtJ	ENSMUSG00225027947	protein coding gene	Chr13:75256037-75282476 (-)
PWK/PhJ	ENSLUMG00010010769	protein coding gene	Chr13:68628841-68655267 (-)
SPRET/EiJ	ENSMSPG00010028562	protein coding gene	Chr13:69525539-69552395 (-)
WSB/EiJ	ENSIUOG00005021717	protein coding gene	Chr13:68391667-68418108 (-)

Human Ortholog

TRIP13, thyroid hormone receptor interactor 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIP13, thyroid hormone receptor interactor 13
Synonyms

16E1BP, MVA3, OOMD9, OZEMA9
Links

HGNC:12307

NCBI Gene ID: 9319

UniProt: Q15645
Chr Location

5p15.33; chr5:892884-919357 (+) GRCh38

MGI Vertebrate Homology

Trip13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRIP13
Gene Tree

Trip13

Diseases

1 with human TRIP13 associations

				Human Disease	Mouse Models
				mosaic variegated aneuploidy syndrome 3 IDs mosaic variegated aneuploidy syndrome 3 DOID:0080689 OMIM:617598

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

52 phenotypes from 4 alleles in 3 genetic backgrounds
2 images
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

13
Targeted

5
Genomic Mutations

1 involving Trip13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit postnatal lethality, infertility, reduced gonad size, tail defects and meiotic arrest of sperm and oocytes associated with unrepaired double strand breaks.

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

934
Tissues

172
cDNA Data

11
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trip13

ZFIN trip13

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All Sequences

53
RefSeq

9
UniProt

3
CCDS

CCDS26637.1

Ensembl

ENSMUSG00000021569 (Evidence)
NCBI Gene

69716

			Length	Strain/Species	Flank
genomic	69716	NCBI Gene Model \| MGI Sequence Detail	25279	C57BL/6J	± kb
transcript	NR_184787	RefSeq \| MGI Sequence Detail	2254	ZRU/MplStud
polypeptide	Q3UA06	UniProt \| EBI \| MGI Sequence Detail	432	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016672 thyroid receptor-interacting protein 13

(term hierarchy)
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR003960 ATPase, AAA-type, conserved site

IPR003959 ATPase, AAA-type, core

IPR001270 ClpA/B family

IPR058249 Pachytene checkpoint protein 2, C-terminal

IPR044539 Pachytene checkpoint protein 2-like

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 16

Genomic 1

cDNA 11

Primer pair 4

Antibodies 1

Microarray probesets 5

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MGI:1196282

Summaries

All 73

Developmental Gene Expression 8

Gene Ontology 10

Phenotypes 31
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:363906 Jiao X, et al., Aberrant activation of chromosome asynapsis checkpoint triggers oocyte elimination. Nat Commun. 2025 Mar 6;16(1):2260

TSS for Trip13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123201	Chr13:74085880-74085906 (-)	-38 bp
Tssr123200	Chr13:74085838-74085863 (-)	4 bp
Tssr123199	Chr13:74085774-74085834 (-)	51 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24