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Lrr1 Gene Detail
Summary
  • Symbol
    Lrr1
  • Name
    leucine rich repeat protein 1
  • Synonyms
    2410005L11Rik, LRR-1, Ppil5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916956
    NCBI Gene: 69706
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:69168814-69179009 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 28.73 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916956
protein coding gene Chr12:69168814-69179012 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019786
protein coding gene Chr12:68830962-68841428 (+)
A/J MGP_AJ_G0019744
protein coding gene Chr12:66276579-66290559 (+)
AKR/J MGP_AKRJ_G0019720
protein coding gene Chr12:68264781-68275427 (+)
BALB/cJ MGP_BALBcJ_G0019724
protein coding gene Chr12:66741947-66752146 (+)
C3H/HeJ MGP_C3HHeJ_G0019530
protein coding gene Chr12:68730693-68740859 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020176
protein coding gene Chr12:71024209-71034162 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017796
protein coding gene Chr12:63825567-63835468 (+)
CAST/EiJ MGP_CASTEiJ_G0019081
protein coding gene Chr12:63476598-63488037 (+)
CBA/J MGP_CBAJ_G0019499
protein coding gene Chr12:73650982-73661315 (+)
DBA/2J MGP_DBA2J_G0019615
protein coding gene Chr12:66196602-66206734 (+)
FVB/NJ MGP_FVBNJ_G0019603
protein coding gene Chr12:65089312-65100559 (+)
LP/J MGP_LPJ_G0019687
protein coding gene Chr12:68789875-68801234 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019641
protein coding gene Chr12:77001320-77013134 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020211
protein coding gene Chr12:67730172-67740290 (+)
PWK/PhJ MGP_PWKPhJ_G0018847
protein coding gene Chr12:60458095-60464622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018642
protein coding gene Chr12:62125970-62136262 (+)
WSB/EiJ MGP_WSBEiJ_G0019132
protein coding gene Chr12:68348870-68359677 (+)



Homology
more
  • Human Ortholog
    LRR1, leucine rich repeat protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRR1, leucine rich repeat protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    4-1BBLRR, LRR-1, PPIL5
  • Links
    NCBI Gene ID: 122769
    neXtProt AC: NX_Q96L50
    UniProt: Q96L50

  • Chr Location
    14q21.3; chr14:49598697-49614672 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32677
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034883 Ensembl Gene Model | MGI Sequence Detail 10196 C57BL/6J ±  kb
transcript ENSMUST00000110621 Ensembl | MGI Sequence Detail 1500 Not Applicable  
polypeptide ENSMUSP00000106251 Ensembl | MGI Sequence Detail 422 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR025875 Leucine rich repeat 4
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 20
    cDNA 20

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144954
References
more
  • Summaries
    All 30
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:137511 Lin Q, et al., Mutagenesis of diploid mammalian genes by gene entrapment. Nucleic Acids Res. 2006;34(20):e139

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory