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Lrr1 Gene Detail
Summary
  • Symbol
    Lrr1
  • Name
    leucine rich repeat protein 1
  • Synonyms
    2410005L11Rik, LRR-1, Ppil5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916956
    NCBI Gene: 69706
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:69168814-69179009 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 28.73 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916956
protein coding gene Chr12:69168789-69179011 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019786
protein coding gene Chr12:68830962-68841428 (+)
A/J MGP_AJ_G0019744
protein coding gene Chr12:66276579-66290559 (+)
AKR/J MGP_AKRJ_G0019720
protein coding gene Chr12:68264781-68275427 (+)
BALB/cJ MGP_BALBcJ_G0019724
protein coding gene Chr12:66741947-66752146 (+)
C3H/HeJ MGP_C3HHeJ_G0019530
protein coding gene Chr12:68730693-68740859 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020176
protein coding gene Chr12:71024209-71034162 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017796
protein coding gene Chr12:63825567-63835468 (+)
CAST/EiJ MGP_CASTEiJ_G0019081
protein coding gene Chr12:63476598-63488037 (+)
CBA/J MGP_CBAJ_G0019499
protein coding gene Chr12:73650982-73661315 (+)
DBA/2J MGP_DBA2J_G0019615
protein coding gene Chr12:66196602-66206734 (+)
FVB/NJ MGP_FVBNJ_G0019603
protein coding gene Chr12:65089312-65100559 (+)
LP/J MGP_LPJ_G0019687
protein coding gene Chr12:68789875-68801234 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019641
protein coding gene Chr12:77001320-77013134 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020211
protein coding gene Chr12:67730172-67740290 (+)
PWK/PhJ MGP_PWKPhJ_G0018847
protein coding gene Chr12:60458095-60464622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018642
protein coding gene Chr12:62125970-62136262 (+)
WSB/EiJ MGP_WSBEiJ_G0019132
protein coding gene Chr12:68348870-68359677 (+)



Homology
more
  • Human Ortholog
    LRR1, leucine rich repeat protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRR1, leucine rich repeat protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    4-1BBLRR, LRR-1, PPIL5
  • Links
    NCBI Gene ID: 122769
    neXtProt AC: NX_Q96L50
    UniProt: Q96L50

  • Chr Location
    14q21.3; chr14:49598697-49614672 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32677
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034883 Ensembl Gene Model | MGI Sequence Detail 10196 C57BL/6J ±  kb
transcript ENSMUST00000110621 Ensembl | MGI Sequence Detail 1500 Not Applicable  
polypeptide ENSMUSP00000106251 Ensembl | MGI Sequence Detail 422 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR025875 Leucine rich repeat 4
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 20
    cDNA 20

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144954
References
more
  • Summaries
    All 30
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:137511 Lin Q, et al., Mutagenesis of diploid mammalian genes by gene entrapment. Nucleic Acids Res. 2006;34(20):e139

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory