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Pof1b
Gene Detail
Symbol

Name
ID
Pof1b
premature ovarian failure 1B
MGI:1916943
Synonyms
2310066B14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome X
48.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:112638431-112698651 bp, - strand
From VEGA annotation of GRCm38

  60221 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: POF1B
Gene Tree: Pof1b

Human
homologs
POF1B, premature ovarian failure, 1B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79983
neXtProt AC: NX_Q8WVV4

Human Synonyms: POF, POF2B

Human Chr (Location): Xq21.2; chrX:85276894-85379743 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human POF1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Both male and female mice homozygous for a targeted knockout mutation of this gene are viable and fertile have no reported abnormal phenotype.
 
Interactions
Pof1b interacts with 289 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component bicellular tight junction, cell junction
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (91)    Tissues (49)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 37
Northern blot 1
RT-PCR 51
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pof1b    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000018382 (Evidence)
Ensembl Gene Model ENSMUSG00000034607 (Evidence)
Entrez Gene 69693 (Evidence)
UniGene 34964
DFCI TC1598393
DoTS DT.40176331
NIA Mouse Gene Index U020166
Consensus CDS Project CCDS30362.1
International Mouse Phenotyping Consortium Status Pof1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018382 VEGA Gene Model | MGI Sequence Detail 60221 C57BL/6J ±  kb
transcript OTTMUST00000044375 VEGA | MGI Sequence Detail 3886 Not Applicable 
polypeptide OTTMUSP00000019935 VEGA | MGI Sequence Detail 587 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(226 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026186 Protein POF1B
Protein Ontology PR:000012957 protein POF1B
References
(Earliest) J:87287 Bione S, et al., X chromosome genes and premature ovarian failure. Semin Reprod Med. 2000;18(1):51-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory