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Pof1b Gene Detail
Summary
  • Symbol
    Pof1b
  • Name
    premature ovarian failure 1B
  • Synonyms
    2310066B14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916943
    NCBI Gene: 69693
  • Gene Overview
    MyGene.info: POF1B
Location & Maps
more
  • Sequence Map
    ChrX:112638431-112698651 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60221 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 48.76 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    POF1B, premature ovarian failure, 1B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    POF1B, premature ovarian failure, 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    POF, POF2B
  • Links
    NCBI Gene ID: 79983
    neXtProt AC: NX_Q8WVV4

  • Chr Location
    Xq21.2; chrX:85276894-85379743 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human POF1B associations

Human Disease Mouse Models
       Premature Ovarian Failure 2B; POF2B   OMIM: 300604
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
  • All Mutations and Alleles
    3
  • Targeted
    3
Both male and female mice homozygous for a targeted knockout mutation of this gene are viable and fertile have no reported abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018382 VEGA Gene Model | MGI Sequence Detail 60221 C57BL/6J ±  kb
transcript OTTMUST00000044375 VEGA | MGI Sequence Detail 3886 Not Applicable  
polypeptide OTTMUSP00000019935 VEGA | MGI Sequence Detail 587 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    229 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 23
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:87287 Bione S, et al., X chromosome genes and premature ovarian failure. Semin Reprod Med. 2000;18(1):51-7
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory