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Il1f8 Gene Detail
Summary
  • Symbol
    Il1f8
  • Name
    interleukin 1 family, member 8
  • Synonyms
    2310043N20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916927
    NCBI Gene: 69677
  • Gene Overview
    MyGene.info: IL36B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:24153172-24160103 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 16.21 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916927
protein coding gene Chr2:24153161-24160519 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025403
protein coding gene Chr2:21935041-21942922 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0025352
protein coding gene Chr2:21923398-21930216 (-)
BALB/cJ MGP_BALBcJ_G0025378
protein coding gene Chr2:21319065-21322860 (-)
C3H/HeJ MGP_C3HHeJ_G0025139
protein coding gene Chr2:21866253-21876729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025820
protein coding gene Chr2:22623061-22628754 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017712
protein coding gene Chr12:33634928-33642128 (-)
CAST/EiJ MGP_CASTEiJ_G0024600
protein coding gene Chr2:21601467-21712224 (-)
CBA/J MGP_CBAJ_G0025117
protein coding gene Chr2:23564806-23570061 (-)
DBA/2J MGP_DBA2J_G0025248
protein coding gene Chr2:20958700-20969721 (+)
FVB/NJ MGP_FVBNJ_G0025210
protein coding gene Chr2:20696062-20704874 (+)
LP/J MGP_LPJ_G0025336
protein coding gene Chr2:21989052-21995450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025241
protein coding gene Chr2:23631933-23645689 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025879
protein coding gene Chr2:21724796-21738019 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    IL36B, interleukin 36 beta
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IL36B, interleukin 36 beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL1-ETA, IL1F8, IL-1F8, IL1H2, IL-1H2
  • Links
    NCBI Gene ID: 27177
    neXtProt AC: NX_Q9NZH7
    UniProt: Q9NZH7

  • Chr Location
    2q14.1; chr2:113022091-113052867 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69677 NCBI Gene Model | MGI Sequence Detail 6932 C57BL/6J ±  kb
transcript NM_027163 RefSeq | MGI Sequence Detail 790 Not Specified  
polypeptide Q9D6Z6 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:227570 Milora KA, et al., Unprocessed Interleukin-36alpha Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1. J Invest Dermatol. 2015 Dec;135(12):2992-3000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory