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Il36b Gene Detail
Summary
  • Symbol
    Il36b
  • Name
    interleukin 36B
  • Synonyms
    2310043N20Rik, If36b, Il1f8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916927
    NCBI Gene: 69677
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:24043184-24050115 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 16.21 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916927
 protein coding gene Chr2:24043173-24050531 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025403
 protein coding gene Chr2:21935041-21942922 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0025352
 protein coding gene Chr2:21923398-21930216 (-)
BALB/cJ MGP_BALBcJ_G0025378
 protein coding gene Chr2:21319065-21322860 (-)
C3H/HeJ MGP_C3HHeJ_G0025139
 protein coding gene Chr2:21866253-21876729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025820
 protein coding gene Chr2:22623061-22628754 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017712
 protein coding gene Chr12:33634928-33642128 (-)
CAST/EiJ MGP_CASTEiJ_G0024600
 protein coding gene Chr2:21601467-21712224 (-)
CBA/J MGP_CBAJ_G0025117
 protein coding gene Chr2:23564806-23570061 (-)
DBA/2J MGP_DBA2J_G0025248
 protein coding gene Chr2:20958700-20969721 (+)
FVB/NJ MGP_FVBNJ_G0025210
 protein coding gene Chr2:20696062-20704874 (+)
LP/J MGP_LPJ_G0025336
 protein coding gene Chr2:21989052-21995450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025241
 protein coding gene Chr2:23631933-23645689 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025879
 protein coding gene Chr2:21724796-21738019 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    IL36B, interleukin 36 beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL36B, interleukin 36 beta
  • Synonyms
    FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL1-ETA, IL1F8, IL-1F8, IL1H2, IL-1H2
  • Links
    NCBI Gene ID: 27177
    neXtProt AC: NX_Q9NZH7
    UniProt: Q9NZH7

  • Chr Location
    2q14.1; chr2:113022089-113052867 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69677 NCBI Gene Model | MGI Sequence Detail 6932 C57BL/6J ±  kb
transcript NM_027163 RefSeq | MGI Sequence Detail 790 Not Specified  
polypeptide Q9D6Z6 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:304905 Ge Y, et al., Effect of Interleukin-36beta on Activating Autophagy of CD4+CD25+ Regulatory T cells and Its Immune Regulation in Sepsis. J Infect Dis. 2020 Oct 1;222(9):1517-1530
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory