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Tmbim1
Gene Detail
 Symbol
Name
ID
Tmbim1
transmembrane BAX inhibitor motif containing 1
MGI:1916910
Synonyms 2310061B02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:74288247-74305622 bp, - strand
From VEGA annotation of GRCm38

  17376 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36404  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glutamate binding protein 1, vertebrate type
Gene Tree: Tmbim1

Human
homologs
Human Homolog TMBIM1, transmembrane BAX inhibitor motif containing 1
NCBI Gene ID 64114
neXtProt AC  NX_Q969X1
Human Synonyms  LFG3, MST100, MSTP100, RECS1
Human Chr (Location)  2q35; chr2:218274194-218292557 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit susceptibility to cystic medial degeneration without inflammation or change in blood pressure.
 
Interactions
Tmbim1 interacts with 178 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process negative regulation of establishment of protein localization to plasma membrane, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, ...
Component endosome, endosome membrane, ...
Function death receptor binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (12)    Tissues (4)    Images (10)
Theiler Stages: 23
Assay TypeResults
RNA in situ 12
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021738 (Evidence)
Ensembl Gene ModelENSMUSG00000006301 (Evidence)
Entrez Gene69660 (Evidence)
DFCITC1572374, TC1591594, TC1641113, TC1778369
DoTSDT.110949874, DT.110949914, DT.87072689, DT.91308423, DT.91430705, DT.94178506
Consensus CDS ProjectCCDS15044.1
International Mouse Knockout Project StatusTmbim1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021738 VEGA Gene Model | MGI Sequence Detail 17376 C57BL/6J ±  kb
transcript OTTMUST00000051569 VEGA | MGI Sequence Detail 11011 Not Applicable 
polypeptide OTTMUSP00000024303 VEGA | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(6) UniProt(8)
Polymorphisms SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006214 Bax inhibitor 1-related
Protein Ontology PR:000029594 protein lifeguard 3
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGI:2138482, MGI:2138674, MGI:2146371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory