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Pir
Gene Detail
Symbol

Name
ID
Pir
pirin
MGI:1916906
Synonyms
2310042L19Rik, iron-binding nuclear protein, pirin, Pirnl
Feature Type
protein coding gene
Genetic Map
Chromosome X
76.12 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:164269371-164373011 bp, + strand
From VEGA annotation of GRCm38

  103641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2717  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIR
Protein SuperFamily: pirin
Gene Tree: Pir

Human
homologs
PIR, pirin (iron-binding nuclear protein)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8544
neXtProt AC: NX_O00625

Human Chr (Location): Xp22.2; chrX:15384799-15493588 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(17) Targeted(3)
Incidental mutations (data from CvDC )
 
About one fifth of male chimeras hemizygous for a gene trapped allele exhibit a developmental delay.
 
Phenotype Images(5)
Interactions
Pir interacts with 77 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process monocyte differentiation, myeloid cell differentiation, ...
Component cytoplasm, nucleus
Function dioxygenase activity, metal ion binding, ...
External Resources: FuncBase
Expression
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pir ; ZFIN pir    NEW 
Molecular
reagents
All nucleic(25) cDNA(25)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000019513 (Evidence)
Ensembl Gene Model ENSMUSG00000031379 (Evidence)
Entrez Gene 69656 (Evidence)
UniGene 293463
DFCI TC1582971
DoTS DT.529343
NIA Mouse Gene Index U020384
EC 1.13.11.24
Consensus CDS Project CCDS30520.1
International Mouse Phenotyping Consortium Status Pir
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019513 VEGA Gene Model | MGI Sequence Detail 103641 C57BL/6J ±  kb
transcript OTTMUST00000046597 VEGA | MGI Sequence Detail 1599 Not Applicable 
polypeptide OTTMUSP00000021043 VEGA | MGI Sequence Detail 290 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(317 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012093 Pirin
InterPro IPR008778 Pirin, C-terminal domain
InterPro IPR003829 Pirin, N-terminal domain
InterPro IPR011051 RmlC-like cupin domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000012750 pirin
References
(Earliest) J:39297 Wendler WMF, et al., Identification of pirin, a novel highly conserved nuclear protein. J Biol Chem. 1997 Mar 28;272(13):8482-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGD-MRK-39585, MGI:109586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory