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Pir
Gene Detail
 Symbol
Name
ID
Pir
pirin
MGI:1916906
Synonyms 2310042L19Rik, iron-binding nuclear protein, pirin, Pirnl
Feature Type protein coding gene
Genetic Map
Chromosome X
76.12 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:164269371-164373011 bp, + strand
From VEGA annotation of GRCm38

  103641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2717  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: pirin
Gene Tree: Pir

Human
homologs
Human Homolog PIR, pirin (iron-binding nuclear protein)
NCBI Gene ID 8544
neXtProt AC  NX_O00625
Human Chr (Location)  Xp22.2; chrX:15384799-15493588 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(17) Targeted(3)
 
About one fifth of male chimeras hemizygous for a gene trapped allele exhibit a developmental delay.
 
Phenotype Images(5)
Interactions
Pir interacts with 77 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process monocyte differentiation, myeloid cell differentiation, ...
Component cytoplasm, nucleus
Function dioxygenase activity, metal ion binding, ...
External Resources: FuncBase
Expression
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(25)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019513 (Evidence)
Ensembl Gene ModelENSMUSG00000031379 (Evidence)
Entrez Gene69656 (Evidence)
UniGene293463
DFCITC1582971
DoTSDT.529343
NIA Mouse Gene IndexU020384
EC1.13.11.24
Consensus CDS ProjectCCDS30520.1
International Mouse Knockout Project StatusPir
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019513 VEGA Gene Model | MGI Sequence Detail 103641 C57BL/6J ±  kb
transcript OTTMUST00000046597 VEGA | MGI Sequence Detail 1599 Not Applicable 
polypeptide OTTMUSP00000021043 VEGA | MGI Sequence Detail 290 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(317 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012093 Pirin
InterPro IPR008778 Pirin, C-terminal domain
InterPro IPR003829 Pirin, N-terminal domain
InterPro IPR011051 RmlC-like cupin domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000012750 pirin
References (Earliest) J:39297 Wendler WMF, et al., Identification of pirin, a novel highly conserved nuclear protein. J Biol Chem. 1997 Mar 28;272(13):8482-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGD-MRK-39585, MGI:109586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory