About   Help   FAQ
Pir Gene Detail
Summary
  • Symbol
    Pir
  • Name
    pirin
  • Synonyms
    2310042L19Rik, iron-binding nuclear protein, pirin, Pirnl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916906
    NCBI Gene: 69656
  • Gene Overview
    MyGene.info: PIR
Location & Maps
more
  • Sequence Map
    ChrX:164269371-164373011 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      103641 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 76.12 cM, cytoband F5
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PIR, pirin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PIR, pirin
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 8544
    neXtProt AC: NX_O00625

  • Chr Location
    Xp22.2; chrX:15384799-15493588 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2717
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PIR
  • Protein SuperFamily
  • Gene Tree
    Pir
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    17
  • Targeted
    3
  • Incidental Mutations
About one fifth of male chimeras hemizygous for a gene trapped allele exhibit a developmental delay.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019513 VEGA Gene Model | MGI Sequence Detail 103641 C57BL/6J ±  kb
transcript OTTMUST00000046597 VEGA | MGI Sequence Detail 1599 Not Applicable  
polypeptide OTTMUSP00000021043 VEGA | MGI Sequence Detail 290 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    316 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39585, MGI:109586
References
more
  • Summaries
    All 35
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:39297 Wendler WMF, et al., Identification of pirin, a novel highly conserved nuclear protein. J Biol Chem. 1997 Mar 28;272(13):8482-9
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory