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Exosc8 Gene Detail
Summary
  • Symbol
    Exosc8
  • Name
    exosome component 8
  • Synonyms
    2310032N20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916889
    NCBI Gene: 69639
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:54636099-54642469 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 25.60 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916889
 protein coding gene Chr3:54636099-54642814 (-)
129S1/SvImJ ENSMUSG00200023097
 protein coding gene Chr3:51488044-51494759 (-)
A/J ENSMUSG00195030450
 protein coding gene Chr3:51424602-51431317 (-)
AKR/J ENSMUSG00220028269
 protein coding gene Chr3:51488439-51495166 (-)
BALB/cJ ENSMUSG00180023647
 protein coding gene Chr3:51509267-51515994 (-)
C3H/HeJ ENSMUSG00175008026
 protein coding gene Chr3:51349055-51355782 (-)
C57BL/6NJ ENSMUSG00215006782
 protein coding gene Chr3:51782644-51789360 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024992
 protein coding gene Chr3:48305939-48312596 (-)
CAST/EiJ ENSTCUG00005009637
 protein coding gene Chr3:51162422-51169152 (-)
CBA/J ENSMUSG00210003514
 protein coding gene Chr3:51470446-51477173 (-)
DBA/2J ENSMUSG00185027348
 protein coding gene Chr3:51684058-51690773 (-)
FVB/NJ ENSMUSG00205009074
 protein coding gene Chr3:50662842-50669557 (-)
JF1/MsJ ENSUMUG00000020107
 protein coding gene Chr3:51117414-51124117 (-)
LP/J ENSMUSG00230004254
 protein coding gene Chr3:53642671-53649386 (-)
NOD/ShiLtJ ENSMUSG00190028219
 protein coding gene Chr3:51836496-51843223 (-)
NZO/HlLtJ ENSMUSG00225015785
 protein coding gene Chr3:56255072-56261787 (-)
PWK/PhJ ENSLUMG00010009234
 protein coding gene Chr3:51238965-51245672 (-)
SPRET/EiJ ENSMSPG00010007023
 protein coding gene Chr3:51996892-52003418 (-)
WSB/EiJ ENSIUOG00005008149
 protein coding gene Chr3:51636402-51643129 (-)



Homology
more
  • Human Ortholog
    EXOSC8, exosome component 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOSC8, exosome component 8
  • Synonyms
    bA421P11.3, CIP3, EAP2, OIP2, p9, PCH1C, RRP43, Rrp43p
  • Links
    NCBI Gene ID: 11340
    UniProt: Q96B26

  • Chr Location
    13q13.3; chr13:36998816-37025881 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EXOSC8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    672
  • Tissues
    56
  • cDNA Data
    11
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69639 NCBI Gene Model | MGI Sequence Detail 6371 C57BL/6J ±  kb
    transcript NM_001163570 RefSeq | MGI Sequence Detail 967 C57BL/6  
    polypeptide Q9D753 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000007265 exosome complex component RRP43
      (term hierarchy)
    • InterPro Domains
      IPR036345 Exoribonuclease, PH domain 2 superfamily
      IPR001247 Exoribonuclease, phosphorolytic domain 1
      IPR015847 Exoribonuclease, phosphorolytic domain 2
      IPR050590 Exosome complex component Rrp42 subfamily
      IPR033196 Exosome complex component Rrp43
      IPR027408 PNPase/RNase PH domain superfamily
      IPR020568 Ribosomal protein uS5 domain 2-type superfamily
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory