About   Help   FAQ
Dapk1
Gene Detail
 Symbol
Name
ID
Dapk1
death associated protein kinase 1
MGI:1916885
Synonyms 2310039H24Rik, 2810425C21Rik, D13Ucla1, DAP-Kinase
Feature Type protein coding gene
Genetic Map
Chromosome 13
32.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:60601947-60763185 bp, + strand
From Ensembl annotation of GRCm38

  161239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3626  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: death-associated protein kinase
Gene Tree: Dapk1

Human
homologs
Human Homolog DAPK1, death-associated protein kinase 1
NCBI Gene ID 1612
neXtProt AC  NX_P53355
Human Synonyms  DAPK
Human Chr (Location)  9q21.33; chr9:87497228-87708651 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(48) : Gene trapped(43) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury.
 
Interactions
Dapk1 interacts with 282 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process apoptotic process, apoptotic signaling pathway, ...
Component actin cytoskeleton, cytoplasm
Function ATP binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (92)    Tissues (57)    Images (18)
Theiler Stages: 15, 16, 19, 20, 23, 26, 28
Assay TypeResults
RNA in situ 50
Northern blot 18
Western blot 18
RNase protection 6
cDNA source data(106)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) cDNA(107) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000021559 (Evidence)
Entrez Gene69635 (Evidence)
UniGene24103
DFCITC1577599, TC1583378, TC1623287, TC1698138
DoTSDT.101137643, DT.101214994, DT.101385345, DT.101385346, DT.484760, DT.97405414
EC2.7.11.1
Consensus CDS ProjectCCDS26581.1
International Mouse Knockout Project StatusDapk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021559 Ensembl Gene Model | MGI Sequence Detail 161239 C57BL/6J ±  kb
transcript ENSMUST00000044083 Ensembl | MGI Sequence Detail 5298 Not Applicable 
polypeptide ENSMUSP00000040825 Ensembl | MGI Sequence Detail 1430 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(12) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(2489 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR020676 Death-associated protein kinase
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR020675 Myosin light chain kinase-related
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000006276 death-associated protein kinase 1
References (Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:211044 Pei L, et al., DAPK1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death. J Neurosci. 2014 May 7;34(19):6546-56
All references(64)
Other
accession IDs
MGD-MRK-3671, MGI:1923806, MGI:2145272, MGI:89882

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory