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Sec24d Gene Detail
Summary
  • Symbol
    Sec24d
  • Name
    Sec24 related gene family, member D (S. cerevisiae)
  • Synonyms
    2310020L09Rik, LOC383951
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916858
    NCBI Gene: 69608
  • Gene Overview
    MyGene.info: SEC24D
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:123267496-123365641 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 53.82 cM, cytoband G3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916858
protein coding gene Chr3:123267455-123365641 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027848
protein coding gene Chr3:125579321-125678111 (+)
A/J MGP_AJ_G0027807
protein coding gene Chr3:121364958-121465445 (+)
AKR/J MGP_AKRJ_G0027772
protein coding gene Chr3:124466093-124566910 (+)
BALB/cJ MGP_BALBcJ_G0027819
protein coding gene Chr3:121179309-121277488 (+)
C3H/HeJ MGP_C3HHeJ_G0027549
protein coding gene Chr3:124863235-124963684 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028264
protein coding gene Chr3:130117383-130219437 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025601
protein coding gene Chr3:116786433-116888322 (+)
CAST/EiJ MGP_CASTEiJ_G0027004
protein coding gene Chr3:124274307-124377613 (+)
CBA/J MGP_CBAJ_G0027524
protein coding gene Chr3:134513041-134624279 (+)
DBA/2J MGP_DBA2J_G0027665
protein coding gene Chr3:120494287-120592440 (+)
FVB/NJ MGP_FVBNJ_G0027633
protein coding gene Chr3:118117389-118218453 (+)
LP/J MGP_LPJ_G0027775
protein coding gene Chr3:127100775-127201981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027663
protein coding gene Chr3:142088439-142205175 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028320
protein coding gene Chr3:124023163-124133372 (+)
PWK/PhJ MGP_PWKPhJ_G0026730
protein coding gene Chr3:120241389-120342432 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026554
protein coding gene Chr3:122129130-122234080 (+)
WSB/EiJ MGP_WSBEiJ_G0027084
protein coding gene Chr3:124769415-124877650 (+)



Homology
more
  • Human Ortholog
    SEC24D, SEC24 homolog D, COPII coat complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC24D, SEC24 homolog D, COPII coat complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLCRP2
  • Links
    NCBI Gene ID: 9871
    neXtProt AC: NX_O94855
    UniProt: O94855

  • Chr Location
    4q26; chr4:118722823-118838683 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SEC24D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early embryonic lethality. A hypomorphic gene trap allele results in lethality during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69608 NCBI Gene Model | MGI Sequence Detail 98146 C57BL/6J ±  kb
transcript NM_027135 RefSeq | MGI Sequence Detail 3881 Not Specified  
polypeptide NP_081411 RefSeq | MGI Sequence Detail 1032 Not Specified  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR029006 ADF-H/Gelsolin-like domain superfamily
    IPR007123 Gelsolin-like domain
    IPR036180 Gelsolin-like domain superfamily
    IPR012990 Sec23/Sec24 beta-sandwich
    IPR006900 Sec23/Sec24, helical domain
    IPR036175 Sec23/Sec24 helical domain superfamily
    IPR006896 Sec23/Sec24, trunk domain
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR006895 Zinc finger, Sec23/Sec24-type
Molecular
Reagents
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  • All nucleic 72
    cDNA 71
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2686195
References
more
  • Summaries
    All 36
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265679 Wang B, et al., The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest. 2018 Aug 1;128(8):3319-3332

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory