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Plekhm2 Gene Detail
Summary
  • Symbol
    Plekhm2
  • Name
    pleckstrin homology domain containing, family M (with RUN domain) member 2
  • Synonyms
    2310034J19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916832
    NCBI Gene: 69582
  • Gene Overview
    MyGene.info: PLEKHM2
Location & Maps
more
  • Sequence Map
    Chr4:141625734-141664899 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      39166 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 74.64 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PLEKHM2, pleckstrin homology and RUN domain containing M2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLEKHM2, pleckstrin homology and RUN domain containing M2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SKIP
  • Links
    NCBI Gene ID: 23207
    neXtProt AC: NX_Q8IWE5

  • Chr Location
    1p36.21; chr1:15684267-15734769 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Plekhm2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    52
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010343 VEGA Gene Model | MGI Sequence Detail 39166 C57BL/6J ±  kb
transcript OTTMUST00000024092 VEGA | MGI Sequence Detail 4136 Not Applicable  
polypeptide OTTMUSP00000011061 VEGA | MGI Sequence Detail 1033 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    418 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000031600 pleckstrin homology domain-containing family M member 2
  • InterPro Domains
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR004012 RUN domain
Molecular
Reagents
less
  • All nucleic 52
    cDNA 52

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140397
References
more
  • Summaries
    All 28
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:233985 Zhao W, et al., The Salmonella effector protein SifA plays a dual role in virulence. Sci Rep. 2015;5:12979
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory