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Plekhm2 Gene Detail
Summary
  • Symbol
    Plekhm2
  • Name
    pleckstrin homology domain containing, family M (with RUN domain) member 2
  • Synonyms
    2310034J19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916832
    NCBI Gene: 69582
  • Gene Overview
    MyGene.info: PLEKHM2
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141625732-141664115 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 74.64 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    417 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916832
 protein coding gene Chr4:141625732-141664899 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029053
 protein coding gene Chr4:144708791-144751046 (-)
A/J MGP_AJ_G0029013
 protein coding gene Chr4:138400669-138441422 (-)
AKR/J MGP_AKRJ_G0028965
 protein coding gene Chr4:142422115-142463873 (-)
BALB/cJ MGP_BALBcJ_G0029037
 protein coding gene Chr4:139095571-139137363 (-)
C3H/HeJ MGP_C3HHeJ_G0028751
 protein coding gene Chr4:142787277-142828132 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029478
 protein coding gene Chr4:149743506-149792316 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026749
 protein coding gene Chr4:131313108-131354427 (-)
CAST/EiJ MGP_CASTEiJ_G0028183
 protein coding gene Chr4:141060068-141099818 (-)
CBA/J MGP_CBAJ_G0028715
 protein coding gene Chr4:154147583-154197765 (-)
DBA/2J MGP_DBA2J_G0028865
 protein coding gene Chr4:138797886-138837919 (-)
FVB/NJ MGP_FVBNJ_G0028832
 protein coding gene Chr4:137916936-137958473 (-)
LP/J MGP_LPJ_G0028964
 protein coding gene Chr4:144730643-144771686 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028858
 protein coding gene Chr4:157902430-157945081 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029516
 protein coding gene Chr4:142938823-142981495 (-)
PWK/PhJ MGP_PWKPhJ_G0027904
 protein coding gene Chr4:135689242-135729431 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027728
 protein coding gene Chr4:138747521-138789371 (-)
WSB/EiJ MGP_WSBEiJ_G0028261
 protein coding gene Chr4:143215635-143254315 (-)



Homology
more
  • Human Ortholog
    PLEKHM2, pleckstrin homology and RUN domain containing M2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLEKHM2, pleckstrin homology and RUN domain containing M2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SKIP
  • Links
    NCBI Gene ID: 23207
    neXtProt AC: NX_Q8IWE5
    UniProt: Q8IWE5

  • Chr Location
    1p36.21; chr1:15681506-15734769 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased leukocyte numbers and decreased susceptibility to Salmonella infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    53
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69582 NCBI Gene Model | MGI Sequence Detail 38384 C57BL/6J ±  kb
transcript NM_001033150 RefSeq | MGI Sequence Detail 4178 C57BL/6  
polypeptide Q80TQ5 UniProt | EBI | MGI Sequence Detail 1018 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140397
References
more
  • Summaries
    All 33
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:256313 Saitoh SI, et al., TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Nat Commun. 2017 Nov 17;8(1):1592
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/06/2018
MGI 6.13 		The Jackson Laboratory