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Antxr1 Gene Detail
Summary
  • Symbol
    Antxr1
  • Name
    anthrax toxin receptor 1
  • Synonyms
    2310008J16Rik, 2810405N18Rik, Tem8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916788
    NCBI Gene: 69538
  • Gene Overview
    MyGene.info: ANTXR1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87133853-87335809 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916788
protein coding gene Chr6:87133853-87335821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030988
protein coding gene Chr6:88475129-88684624 (-)
A/J MGP_AJ_G0030954
protein coding gene Chr6:85055468-85255713 (-)
AKR/J MGP_AKRJ_G0030885
protein coding gene Chr6:87528897-87726111 (-)
BALB/cJ MGP_BALBcJ_G0030967
protein coding gene Chr6:85063284-85257336 (-)
C3H/HeJ MGP_C3HHeJ_G0030743
protein coding gene Chr6:96753571-96959004 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031424
protein coding gene Chr6:90861004-91065796 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028608
protein coding gene Chr6:83235283-83450491 (-)
CAST/EiJ MGP_CASTEiJ_G0030076
protein coding gene Chr6:87584566-87795402 (-)
CBA/J MGP_CBAJ_G0030651
protein coding gene Chr6:94417608-94613674 (-)
DBA/2J MGP_DBA2J_G0030807
protein coding gene Chr6:84361835-84561379 (-)
FVB/NJ MGP_FVBNJ_G0030760
protein coding gene Chr6:83544552-83742305 (-)
LP/J MGP_LPJ_G0030884
protein coding gene Chr6:88492684-88697702 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030793
protein coding gene Chr6:98523520-98728043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031451
protein coding gene Chr6:87363228-87568496 (-)
PWK/PhJ MGP_PWKPhJ_G0029791
protein coding gene Chr6:83323803-83523809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029619
protein coding gene Chr6:86183658-86383359 (-)
WSB/EiJ MGP_WSBEiJ_G0030157
protein coding gene Chr6:87828886-88023558 (-)



Homology
more
  • Human Ortholog
    ANTXR1, ANTXR cell adhesion molecule 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ANTXR1, ANTXR cell adhesion molecule 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATR, GAPO, TEM8
  • Links
    NCBI Gene ID: 84168
    neXtProt AC: NX_Q9H6X2
    UniProt: Q9H6X2

  • Chr Location
    2p13.3; chr2:69013144-69249327 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display female infertility and malocclusion of the incisors. Mice homozygous for a different knock-out allele exhibit malocclusion of incisors and increased extracellular matrix deposition in several organs, includingthe ovaries and uterus, but normal fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69538 NCBI Gene Model | MGI Sequence Detail 201957 C57BL/6J ±  kb
transcript NM_054041 RefSeq | MGI Sequence Detail 5280 C57BL/6  
polypeptide Q9CZ52 UniProt | EBI | MGI Sequence Detail 562 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919432
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265482 Szot C, et al., Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release. J Clin Invest. 2018 Jul 2;128(7):2927-2943

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory