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Antxr1 Gene Detail
Summary
  • Symbol
    Antxr1
  • Name
    anthrax toxin receptor 1
  • Synonyms
    2310008J16Rik, 2810405N18Rik, Tem8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916788
    NCBI Gene: 69538
  • Gene Overview
    MyGene.info: ANTXR1
Location & Maps
more
  • Sequence Map
    Chr6:87133853-87335821 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      201969 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.94 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANTXR1, anthrax toxin receptor 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ANTXR1, anthrax toxin receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATR, GAPO, TEM8
  • Links
    NCBI Gene ID: 84168
    neXtProt AC: NX_Q9H6X2

  • Chr Location
    2p13.1; chr2:69013144-69249327 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human ANTXR1 associations

Human Disease Mouse Models
       GAPO Syndrome   OMIM: 230740
Hemangioma, Capillary Infantile   OMIM: 602089
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    2
  • Spontaneous
    1
  • Targeted
    9
  • Genomic Mutations
    1 involving Antxr1
  • Incidental Mutations
Mice homozygous for a null mutation display female infertility and malocclusion of the incisors. Mice homozygous for a different knock-out allele exhibit malocclusion of incisors and increased extracellular matrix deposition in several organs, includingthe ovaries and uterus, but normal fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057167 VEGA Gene Model | MGI Sequence Detail 201969 C57BL/6J ±  kb
transcript OTTMUST00000140765 VEGA | MGI Sequence Detail 5253 Not Applicable  
polypeptide OTTMUSP00000073670 VEGA | MGI Sequence Detail 562 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1368 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004068 anthrax toxin receptor 1
  • InterPro Domains
    IPR017360 Anthrax toxin receptor
    IPR008399 Anthrax toxin receptor, C-terminal
    IPR008400 Anthrax toxin receptor, extracellular
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919432
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224431 Besschetnova TY, et al., Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 2015 Mar;42:56-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory