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Antxr1
Gene Detail
Symbol

Name
ID
Antxr1
anthrax toxin receptor 1
MGI:1916788
Synonyms
2310008J16Rik, 2810405N18Rik, Tem8
Feature Type
protein coding gene
Genetic Map
Chromosome 6
37.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:87133854-87335775 bp, - strand
From Ensembl annotation of GRCm38

  201922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12976  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: anthrax toxin receptor
Gene Tree: Antxr1

Human
homologs
Human Homolog ANTXR1, anthrax toxin receptor 1
NCBI Gene ID 84168
neXtProt AC  NX_Q9H6X2
Human Synonyms  ATR, GAPO, TEM8
Human Chr (Location)  2p13.1; chr2:69013144-69249327 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ANTXR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display female infertility and malocclusion of the incisors. Mice homozygous for a different knock-out allele exhibit malocclusion of incisors and increased extracellular matrix deposition in several organs, including the ovaries and uterus, but normal fertility.
 
Interactions
Antxr1 interacts with 393 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process actin cytoskeleton reorganization, reproductive process, ...
Component cell projection, cell surface, ...
Function actin filament binding, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000033420 (Evidence)
Entrez Gene69538 (Evidence)
DFCITC1589096, TC1598119, TC1599186
DoTSDT.101217282, DT.101280285, DT.534446, DT.97358167
NIA Mouse Gene IndexU054961
Consensus CDS ProjectCCDS20318.1
International Mouse Knockout Project StatusAntxr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033420 Ensembl Gene Model | MGI Sequence Detail 201922 C57BL/6J ±  kb
transcript ENSMUST00000042025 Ensembl | MGI Sequence Detail 5263 Not Applicable 
polypeptide ENSMUSP00000045634 Ensembl | MGI Sequence Detail 562 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(1373 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017360 Anthrax toxin receptor
InterPro IPR008399 Anthrax toxin receptor, C-terminal
InterPro IPR008400 Anthrax toxin receptor, extracellular
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000004068 anthrax toxin receptor 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181461 Chaudhary A, et al., TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types. Cancer Cell. 2012 Feb 14;21(2):212-26
All references(35)
Other
accession IDs
MGI:1919432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory