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Hopx Gene Detail
Summary
  • Symbol
    Hopx
  • Name
    HOP homeobox
  • Synonyms
    1110018K11Rik, 1200015P04Rik, 2300002F06Rik, Cameo, Hod, Hop, Ob1, Toto
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916782
    NCBI Gene: 74318
  • Gene Overview
    MyGene.info: HOPX
Location & Maps
more
  • Sequence Map
    Chr5:77086988-77115121 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28134 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 41.45 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HOPX, HOP homeobox
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOPX, HOP homeobox
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO
  • Links
    NCBI Gene ID: 84525
    neXtProt AC: NX_Q9BPY8

  • Chr Location
    4q12; chr4:56647988-56681706 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 15859
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: HOPX
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    3 involving Hopx
Homozygous inactivation of this gene causes partial embryonic lethality due to severe developmental cardiac anomalies involving the myocardium, and leads to conduction defects in surviving adults. Mice homozygous for one null allele also exhibit impairedlung maturation leading to neonatal death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026555 VEGA Gene Model | MGI Sequence Detail 28134 C57BL/6J ±  kb
transcript OTTMUST00000065746 VEGA | MGI Sequence Detail 1113 Not Applicable  
polypeptide OTTMUSP00000032808 VEGA | MGI Sequence Detail 73 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    230 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 15
    Primer pair 4
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914646, MGI:1921568, MGI:2140984, MGI:2141197
References
more
  • Summaries
    All 74
    Developmental Gene Expression 35
    Gene Ontology 13
    Phenotypes 26
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229471 Branchfield K, et al., Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12;351(6274):707-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory