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Hopx
Gene Detail
 Symbol
Name
ID
Hopx
HOP homeobox
MGI:1916782
Synonyms 1110018K11Rik, 1200015P04Rik, 2300002F06Rik, Cameo, Hod, Hop, Ob1, Toto
Feature Type protein coding gene
Genetic Map
Chromosome 5
41.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:77086988-77115121 bp, - strand
From VEGA annotation of GRCm38

  28134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Hopx

Human
homologs
Human Homolog HOPX, HOP homeobox
NCBI Gene ID 84525
neXtProt AC  NX_Q9BPY8
Human Synonyms  CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO
Human Chr (Location)  4q12; chr4:56647988-56681709 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
 
Homozygous inactivation of this gene causes partial embryonic lethality due to severe developmental cardiac anomalies involving the myocardium, and leads to conduction defects in surviving adults. Mice homozygous for one null allele also exhibit impaired lung maturation leading to neonatal death.
 
Interactions
Hopx interacts with 184 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process heart development, histone deacetylation, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (215)    Tissues (102)    Images (28)
Theiler Stages: 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 17, 18, 21, 23, 24, 27, 28
Assay TypeResults
RNA in situ 183
Western blot 4
RT-PCR 28
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(14) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026555 (Evidence)
Ensembl Gene ModelENSMUSG00000059325 (Evidence)
Entrez Gene74318 (Evidence)
DFCITC1579980, TC1589819, TC1665418
DoTSDT.101383230, DT.101735959, DT.91339290, DT.94240981
PDB1UHS, 2HI3
Consensus CDS ProjectCCDS39120.1
International Mouse Knockout Project StatusHopx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026555 VEGA Gene Model | MGI Sequence Detail 28134 C57BL/6J ±  kb
transcript OTTMUST00000065747 VEGA | MGI Sequence Detail 1217 Not Applicable 
polypeptide OTTMUSP00000032809 VEGA | MGI Sequence Detail 73 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(230 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008685 homeodomain-only protein
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(70)
Other
accession IDs
MGI:1914646, MGI:1921568, MGI:2140984, MGI:2141197

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory