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Hopx
Gene Detail
Symbol

Name
ID
Hopx
HOP homeobox
MGI:1916782
Synonyms
1110018K11Rik, 1200015P04Rik, 2300002F06Rik, Cameo, Hod, Hop, Ob1, Toto
Feature Type
protein coding gene
Genetic Map
Chromosome 5
41.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:77086988-77115121 bp, - strand
From VEGA annotation of GRCm38

  28134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: HOPX
Gene Tree: Hopx

Human
homologs
HOPX, HOP homeobox
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84525
neXtProt AC: NX_Q9BPY8

Human Synonyms: CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO

Human Chr (Location): 4q12; chr4:56647988-56681706 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
 
Homozygous inactivation of this gene causes partial embryonic lethality due to severe developmental cardiac anomalies involving the myocardium, and leads to conduction defects in surviving adults. Mice homozygous for one null allele also exhibit impaired lung maturation leading to neonatal death.
 
Interactions
Hopx interacts with 183 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process heart development, histone deacetylation, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (271)    Tissues (133)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 44
RNA in situ 195
Western blot 4
RT-PCR 28
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hopx ; ZFIN hopx    NEW 
Molecular
reagents
All nucleic(20) cDNA(15) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026555 (Evidence)
Ensembl Gene Model ENSMUSG00000059325 (Evidence)
Entrez Gene 74318 (Evidence)
DFCI TC1579980, TC1589819, TC1665418
DoTS DT.101383230, DT.101735959, DT.91339290, DT.94240981
PDB 1UHS, 2HI3
Consensus CDS Project CCDS39120.1
International Mouse Phenotyping Consortium Status Hopx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026555 VEGA Gene Model | MGI Sequence Detail 28134 C57BL/6J ±  kb
transcript OTTMUST00000065708 VEGA | MGI Sequence Detail 1261 Not Applicable 
polypeptide OTTMUSP00000032784 VEGA | MGI Sequence Detail 73 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(230 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008685 homeodomain-only protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:222725 Jain R, et al., Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun. 2015;6:6727
All references(74)
Other
accession IDs
MGI:1914646, MGI:1921568, MGI:2140984, MGI:2141197

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory