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Tsr2 Gene Detail
Summary
  • Symbol
    Tsr2
  • Name
    TSR2 20S rRNA accumulation
  • Synonyms
    2310007F12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916749
    NCBI Gene: 69499
Location & Maps
more
  • Sequence Map
    ChrX:151087094-151096543 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9450 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TSR2, TSR2, ribosome maturation factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TSR2, TSR2, ribosome maturation factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DBA14, DT1P1A10, WGG1
  • Links
    NCBI Gene ID: 90121
    neXtProt AC: NX_Q969E8

  • Chr Location
    Xp11.22; chrX:54440420-54445297 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 43235
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: TSR2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TSR2 associations

Human Disease Mouse Models
       Diamond-Blackfan Anemia 14 with Mandibulofacial Dysostosis; DBA14   OMIM: 300946
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    2
  • Gene trapped
    1
  • Targeted
    1
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019291 VEGA Gene Model | MGI Sequence Detail 9450 C57BL/6J ±  kb
transcript OTTMUST00000046113 VEGA | MGI Sequence Detail 3796 Not Applicable  
polypeptide OTTMUSP00000020817 VEGA | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016767 pre-rRNA-processing protein TSR2
  • InterPro Domains
    IPR019398 Pre-rRNA-processing protein TSR2
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory