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Tmem127
Gene Detail
Symbol

Name
ID
Tmem127
transmembrane protein 127
MGI:1916720
Synonyms
2310003P10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
61.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:127247908-127261107 bp, + strand
From VEGA annotation of GRCm38

  13200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9877  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tmem127

Human
homologs
Human Homolog TMEM127, transmembrane protein 127
NCBI Gene ID 55654
neXtProt AC  NX_O75204
Human Chr (Location)  2q11.2; chr2:96250208-96266013 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TMEM127
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Lysosomal activity and endosomal fusion mediated by Rab5 were affected in mouse embryonic fibroblasts of homozygous null mutants
 
Interactions
Tmem127 interacts with 358 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process endosome organization, negative regulation of cell proliferation, ...
Component cytoplasm, early endosome, ...
Function Rab GTPase binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (2)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016014 (Evidence)
Ensembl Gene ModelENSMUSG00000034850 (Evidence)
Entrez Gene69470 (Evidence)
DFCITC1578097, TC1597992
DoTSDT.489517
NIA Mouse Gene IndexU002432
Consensus CDS ProjectCCDS16697.1
International Mouse Knockout Project StatusTmem127
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016014 VEGA Gene Model | MGI Sequence Detail 13200 C57BL/6J ±  kb
transcript OTTMUST00000038158 VEGA | MGI Sequence Detail 4811 Not Applicable 
polypeptide OTTMUSP00000017112 VEGA | MGI Sequence Detail 238 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000029797 transmembrane protein 127
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209071 Qin Y, et al., The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. Hum Mol Genet. 2014 May 1;23(9):2428-39
All references(35)
Other
accession IDs
MGI:2138878, MGI:2138898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory