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Clic3 Gene Detail
Summary
  • Symbol
    Clic3
  • Name
    chloride intracellular channel 3
  • Synonyms
    2300003G24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916704
    NCBI Gene: 69454
  • Gene Overview
    MyGene.info: CLIC3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25456843-25458772 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.27 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916704
protein coding gene Chr2:25456838-25458776 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025448
protein coding gene Chr2:23345355-23347293 (+)
A/J MGP_AJ_G0025425
protein coding gene Chr2:22442615-22444553 (+)
AKR/J MGP_AKRJ_G0025395
protein coding gene Chr2:23189422-23191360 (+)
BALB/cJ MGP_BALBcJ_G0025421
protein coding gene Chr2:22554173-22556111 (+)
C3H/HeJ MGP_C3HHeJ_G0025182
protein coding gene Chr2:23137907-23139845 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025865
protein coding gene Chr2:24091694-24093632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023276
protein coding gene Chr2:21352840-21354766 (+)
CAST/EiJ MGP_CASTEiJ_G0024645
protein coding gene Chr2:23007754-23009692 (+)
CBA/J MGP_CBAJ_G0025160
protein coding gene Chr2:24925248-24927186 (+)
DBA/2J MGP_DBA2J_G0025293
protein coding gene Chr2:22280303-22282241 (+)
FVB/NJ MGP_FVBNJ_G0025255
protein coding gene Chr2:22024862-22026800 (+)
LP/J MGP_LPJ_G0025379
protein coding gene Chr2:23286620-23288558 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025286
protein coding gene Chr2:25120712-25122650 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025924
protein coding gene Chr2:23144273-23146211 (+)
PWK/PhJ MGP_PWKPhJ_G0024393
protein coding gene Chr2:22102095-22104033 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024193
protein coding gene Chr2:23285202-23287133 (+)
WSB/EiJ MGP_WSBEiJ_G0024714
protein coding gene Chr2:23220755-23222693 (+)



Homology
more
  • Human Ortholog
    CLIC3, chloride intracellular channel 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLIC3, chloride intracellular channel 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9022
    neXtProt AC: NX_O95833
    UniProt: O95833

  • Chr Location
    9q34.3; chr9:136994608-136997929 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69454 NCBI Gene Model | MGI Sequence Detail 1930 C57BL/6J ±  kb
transcript NM_027085 RefSeq | MGI Sequence Detail 799 C57BL/6  
polypeptide Q9D7P7 UniProt | EBI | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005576 chloride intracellular channel protein 3
  • InterPro Domains
    IPR030261 Chloride intracellular channel protein 3
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR004045 Glutathione S-transferase, N-terminal
    IPR002946 Intracellular chloride channel
    IPR036249 Thioredoxin-like superfamily
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:193838 Kim KH, et al., CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner. Eur J Immunol. 2013 Mar;43(3):667-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory