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Pex5l Gene Detail
Summary
  • Symbol
    Pex5l
  • Name
    peroxisomal biogenesis factor 5-like
  • Synonyms
    1700016J08Rik, Pex2, PXR2, TRIP8b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916672
    NCBI Gene: 58869
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:32949408-33143247 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 15.94 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1448 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916672
protein coding gene Chr3:32947926-33143274 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027145
protein coding gene Chr3:30588725-30793474 (-)
A/J MGP_AJ_G0027105
protein coding gene Chr3:30147822-30345003 (-)
AKR/J MGP_AKRJ_G0027074
protein coding gene Chr3:30629994-30835190 (-)
BALB/cJ MGP_BALBcJ_G0027117
protein coding gene Chr3:29789997-29986295 (-)
C3H/HeJ MGP_C3HHeJ_G0026860
protein coding gene Chr3:30654802-30858527 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027563
protein coding gene Chr3:32100114-32318893 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024924
protein coding gene Chr3:27935017-28134990 (-)
CAST/EiJ MGP_CASTEiJ_G0026313
protein coding gene Chr3:30510090-30714547 (-)
CBA/J MGP_CBAJ_G0026837
protein coding gene Chr3:32972121-33189466 (-)
DBA/2J MGP_DBA2J_G0026971
protein coding gene Chr3:29609939-29805612 (-)
FVB/NJ MGP_FVBNJ_G0026939
protein coding gene Chr3:29063401-29260489 (-)
LP/J MGP_LPJ_G0027083
protein coding gene Chr3:31348422-31551872 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026959
protein coding gene Chr3:35455393-35659213 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027622
protein coding gene Chr3:30426711-30630418 (-)
PWK/PhJ MGP_PWKPhJ_G0026046
protein coding gene Chr3:29148642-29347167 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025858
protein coding gene Chr3:29849038-30045705 (-)
WSB/EiJ MGP_WSBEiJ_G0026387
protein coding gene Chr3:30432575-30638911 (-)



Homology
more
  • Human Ortholog
    PEX5L, peroxisomal biogenesis factor 5 like
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PEX5L, peroxisomal biogenesis factor 5 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PEX5R, PEX5RP, PXR2, PXR2B, TRIP8b
  • Links
    NCBI Gene ID: 51555
    neXtProt AC: NX_Q8IYB4
    UniProt: Q8IYB4

  • Chr Location
    3q26.33; chr3:179794958-180037053 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9562
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PEX5L
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation lacking isoform b exhibit exhibit reduced hyperpolarization-activated current in CA1 pyramidal neuron, impaired motor learning, impaired nest-building, decreased startle reflex, and decreased depression-related behaviors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027674 Ensembl Gene Model | MGI Sequence Detail 193840 C57BL/6J ±  kb
transcript ENSMUST00000194016 Ensembl | MGI Sequence Detail 4206 Not Applicable  
polypeptide ENSMUSP00000142196 Ensembl | MGI Sequence Detail 650 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    12 Sequences
  • PDB
  • InterPro Domains
    IPR024111 Peroxisomal targeting signal 1 receptor family
    IPR024112 PEX5-related
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 6
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:271393 Yun S, et al., Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive. Nat Med. 2018 May;24(5):658-666

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory