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Pex5l
Gene Detail
Symbol

Name
ID
Pex5l
peroxisomal biogenesis factor 5-like
MGI:1916672
Synonyms
1700016J08Rik, Pex2, PXR2, TRIP8b
Feature Type
protein coding gene
Genetic Map
Chromosome 3
15.94 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:32949408-33143247 bp, - strand
From VEGA annotation of GRCm38

  193840 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9562  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PEX5L
Gene Tree: Pex5l

Human
homologs
PEX5L, peroxisomal biogenesis factor 5-like
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51555
neXtProt AC: NX_Q8IYB4

Human Synonyms: PEX5R, PEX5RP, PXR2, PXR2B, TRIP8b

Human Chr (Location): 3q26.33; chr3:179794958-180037053 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation lacking isoform b exhibit exhibit reduced hyperpolarization-activated current in CA1 pyramidal neuron, impaired motor learning, impaired nest-building, decreased startle reflex, and decreased depression-related behaviors.
 
Interactions
Pex5l interacts with 241 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (3)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pex5l    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000023437 (Evidence)
Ensembl Gene Model ENSMUSG00000027674 (Evidence)
Entrez Gene 58869 (Evidence)
DFCI TC1581677, TC1606672, TC1607861, TC1608866, TC1616037, TC1633373, TC1661091
DoTS DT.101197191, DT.101360305, DT.101361294, DT.110469255, DT.55219919, DT.55242977, DT.55251832, DT.91302558, DT.91583487
NIA Mouse Gene Index U023925, U184258
PDB 4EQF
Consensus CDS Project CCDS17302.1, CCDS50888.1, CCDS50889.1, CCDS79893.1, CCDS79894.1
International Mouse Phenotyping Consortium Status Pex5l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023437 VEGA Gene Model | MGI Sequence Detail 193840 C57BL/6J ±  kb
transcript OTTMUST00000130900 VEGA | MGI Sequence Detail 4206 Not Applicable 
polypeptide OTTMUSP00000070090 VEGA | MGI Sequence Detail 650 Not Applicable 

For the selected sequences
All sequences(149) RefSeq(48) UniProt(12)
Polymorphisms
SNPs within 2kb(1455 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024111 Peroxisomal targeting signal 1 receptor family
InterPro IPR024112 PEX5-related
InterPro IPR011990 Tetratricopeptide-like helical domain
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR001440 Tetratricopeptide repeat 1
InterPro IPR013026 Tetratricopeptide repeat-containing domain
Protein Ontology PR:000012566 PEX5-related protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory