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Pex5l
Gene Detail
 Symbol
Name
ID
Pex5l
peroxisomal biogenesis factor 5-like
MGI:1916672
Synonyms 1700016J08Rik, Pex2, PXR2, TRIP8b
Feature Type protein coding gene
Genetic Map
Chromosome 3
15.94 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:32949634-33143247 bp, - strand
From VEGA annotation of GRCm38

  193614 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9562  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pex5l

Human
homologs
Human Homolog PEX5L, peroxisomal biogenesis factor 5-like
NCBI Gene ID 51555
neXtProt AC  NX_Q8IYB4
Human Synonyms  PEX5R, PEX5RP, PXR2, PXR2B, TRIP8b
Human Chr (Location)  3q26.33; chr3:179794958-180037053 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation lacking isoform b exhibit exhibit reduced hyperpolarization-activated current in CA1 pyramidal neuron, impaired motor learning, impaired nest-building, decreased startle reflex, and decreased depression-related behaviors.
 
Interactions
Pex5l interacts with 242 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cation transport, ion transmembrane transport, ...
Component cell tip, cytoplasm, ...
Function intracellular cyclic nucleotide activated cation channel activity, peroxisome matrix targeting signal-1 binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (2)    Images (4)
Theiler Stages: 28
Assay TypeResults
RNA in situ 5
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000023437 (Evidence)
Ensembl Gene ModelENSMUSG00000027674 (Evidence)
Entrez Gene58869 (Evidence)
DFCITC1581677, TC1606672, TC1607861, TC1608866, TC1616037, TC1633373, TC1661091
DoTSDT.101197191, DT.101360305, DT.101361294, DT.110469255, DT.55219919, DT.55242977, DT.55251832, DT.91302558, DT.91583487
NIA Mouse Gene IndexU023925, U184258
PDB4EQF
Consensus CDS ProjectCCDS17302.1, CCDS50888.1, CCDS50889.1
International Mouse Knockout Project StatusPex5l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023437 VEGA Gene Model | MGI Sequence Detail 193614 C57BL/6J ±  kb
transcript OTTMUST00000056965 VEGA | MGI Sequence Detail 3164 Not Applicable 
polypeptide OTTMUSP00000027435 VEGA | MGI Sequence Detail 615 Not Applicable 

For the selected sequences
All sequences(109) RefSeq(22) UniProt(13)
Polymorphisms SNPs within 2kb(1453 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024111 Peroxisomal targeting signal 1 receptor family
InterPro IPR024112 PEX5-related
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000012566 PEX5-related protein
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory