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Zpbp2 Gene Detail
Summary
  • Symbol
    Zpbp2
  • Name
    zona pellucida binding protein 2
  • Synonyms
    1700017D11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916626
    NCBI Gene: 69376
  • Gene Overview
    MyGene.info: ZPBP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98551097-98558665 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.97 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916626
protein coding gene Chr11:98551097-98558665 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019063
protein coding gene Chr11:101110946-101118497 (+)
A/J MGP_AJ_G0019031
protein coding gene Chr11:96899123-96906791 (+)
AKR/J MGP_AKRJ_G0019001
protein coding gene Chr11:99901851-99909392 (+)
BALB/cJ MGP_BALBcJ_G0019004
protein coding gene Chr11:97393356-97400761 (+)
C3H/HeJ MGP_C3HHeJ_G0018818
protein coding gene Chr11:100038425-100045992 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019457
protein coding gene Chr11:104196717-104205494 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017088
protein coding gene Chr11:94338835-94346259 (+)
CAST/EiJ MGP_CASTEiJ_G0018372
protein coding gene Chr11:100923881-100931464 (+)
CBA/J MGP_CBAJ_G0018789
protein coding gene Chr11:108513417-108520822 (+)
DBA/2J MGP_DBA2J_G0018897
protein coding gene Chr11:96442296-96450366 (+)
FVB/NJ MGP_FVBNJ_G0018886
protein coding gene Chr11:95953530-95961128 (+)
LP/J MGP_LPJ_G0018967
protein coding gene Chr11:101582991-101590552 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018913
protein coding gene Chr11:108293036-108301529 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019497
protein coding gene Chr11:100233305-100241642 (+)
PWK/PhJ MGP_PWKPhJ_G0018144
protein coding gene Chr11:97448035-97461189 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017934
protein coding gene Chr11:99930483-99939481 (+)
WSB/EiJ MGP_WSBEiJ_G0018422
protein coding gene Chr11:100161035-100168636 (+)



Homology
more
  • Human Ortholog
    ZPBP2, zona pellucida binding protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ZPBP2, zona pellucida binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZPBPL
  • Links
    NCBI Gene ID: 124626
    neXtProt AC: NX_Q6X784
    UniProt: Q6X784

  • Chr Location
    17q21.1; chr17:39868164-39877896 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation display reduced fecundity, mild teratozoospermia, and delayed fertilization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69376 NCBI Gene Model | MGI Sequence Detail 7569 C57BL/6J ±  kb
    transcript NM_001166494 RefSeq | MGI Sequence Detail 1639 C57BL/6  
    polypeptide Q6X786 UniProt | EBI | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 12
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:260850 Kanagaratham C, et al., Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion. Mamm Genome. 2018 Apr;29(3-4):281-298

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory