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Spaca4 Gene Detail
Summary
  • Symbol
    Spaca4
  • Name
    sperm acrosome associated 4
  • Synonyms
    1700008E09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916613
    NCBI Gene: 69363
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45374531-45375237 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916613
protein coding gene Chr7:45374531-45375240 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032245
protein coding gene Chr7:46035833-46036539 (-)
A/J MGP_AJ_G0032224
protein coding gene Chr7:45121085-45121791 (-)
AKR/J MGP_AKRJ_G0032160
protein coding gene Chr7:46375648-46376354 (-)
BALB/cJ MGP_BALBcJ_G0032236
protein coding gene Chr7:45117400-45118106 (-)
C3H/HeJ MGP_C3HHeJ_G0031951
protein coding gene Chr7:46867441-46868147 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032728
protein coding gene Chr7:48285874-48286580 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029742
protein coding gene Chr7:47675057-47675764 (-)
CAST/EiJ MGP_CASTEiJ_G0031279
protein coding gene Chr7:38308859-38309565 (-)
CBA/J MGP_CBAJ_G0031916
protein coding gene Chr7:49894833-49895539 (-)
DBA/2J MGP_DBA2J_G0032074
protein coding gene Chr7:44801691-44802397 (-)
FVB/NJ MGP_FVBNJ_G0032025
protein coding gene Chr7:44575494-44576200 (-)
LP/J MGP_LPJ_G0032152
protein coding gene Chr7:46741365-46742071 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032062
protein coding gene Chr7:48576959-48577665 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032744
protein coding gene Chr7:45587876-45588582 (-)
PWK/PhJ MGP_PWKPhJ_G0031002
protein coding gene Chr7:38170051-38170757 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030840
protein coding gene Chr7:33618537-33619243 (-)
WSB/EiJ MGP_WSBEiJ_G0031397
protein coding gene Chr7:46090908-46091614 (-)



Homology
more
  • Human Ortholog
    SPACA4, sperm acrosome associated 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPACA4, sperm acrosome associated 4
  • Synonyms
    SAMP14
  • Links
    NCBI Gene ID: 171169
    neXtProt AC: NX_Q8TDM5
    UniProt: Q8TDM5

  • Chr Location
    19q13.33; chr19:48606743-48607714 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles exhibit reduced male fertility associated with impaired egg binding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070563 Ensembl Gene Model | MGI Sequence Detail 707 C57BL/6J ±  kb
    transcript ENSMUST00000094424 Ensembl | MGI Sequence Detail 707 Not Applicable  
    polypeptide ENSMUSP00000091991 Ensembl | MGI Sequence Detail 127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000015450 sperm acrosome membrane-associated protein 4
    • InterPro Domains
      IPR016054 Ly-6 antigen/uPA receptor-like
      IPR045860 Snake toxin-like superfamily
      IPR046354 Sperm acrosome membrane-associated protein 4/Protein Bouncer
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142173
    References
    more
    • Summaries
      All 23
      Gene Ontology 2
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:311165 Fujihara Y, et al., The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2108777118

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    08/09/2022
    MGI 6.21
    The Jackson Laboratory