Lrrc51 MGI Mouse Gene Detail - MGI:1916608 - leucine rich repeat containing 51

Symbol

Lrrc51
Name

leucine rich repeat containing 51
Synonyms

1700008D07Rik, Lrtomt

Feature Type

protein coding gene
IDs

MGI:1916608
NCBI Gene: 69358
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:101562191-101583102 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.69 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

107 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916608	protein coding gene	Chr7:101562191-101583126 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032594	protein coding gene	Chr7:104930072-104954837 (-)
A/J	MGP_AJ_G0032570	protein coding gene	Chr7:102257623-102278495 (-)
AKR/J	MGP_AKRJ_G0032506	protein coding gene	Chr7:104703137-104726388 (-)
BALB/cJ	MGP_BALBcJ_G0032581	protein coding gene	Chr7:101955738-101976307 (-)
C3H/HeJ	MGP_C3HHeJ_G0032295	protein coding gene	Chr7:105077095-105098351 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033078	protein coding gene	Chr7:108882825-108916885 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030072	protein coding gene	Chr7:104620203-104643301 (-)
CAST/EiJ	MGP_CASTEiJ_G0031621	protein coding gene	Chr7:96635052-96657083 (-)
CBA/J	MGP_CBAJ_G0032261	protein coding gene	Chr7:112657022-112680082 (-)
DBA/2J	MGP_DBA2J_G0032413	protein coding gene	Chr7:100588128-100609409 (-)
FVB/NJ	MGP_FVBNJ_G0032369	protein coding gene	Chr7:100369207-100390131 (-)
LP/J	MGP_LPJ_G0032502	protein coding gene	Chr7:106247890-106272393 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032403	protein coding gene	Chr7:113981787-114005291 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033100	protein coding gene	Chr7:103974236-103998939 (-)
PWK/PhJ	MGP_PWKPhJ_G0031339	protein coding gene	Chr7:93699986-93721259 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031183	protein coding gene	Chr7:91272106-91296200 (-)
WSB/EiJ	MGP_WSBEiJ_G0031738	protein coding gene	Chr7:104663913-104688077 (-)

Human Ortholog

LRRC51, leucine rich repeat containing 51

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC51, leucine rich repeat containing 51
Links

HGNC:55526

NCBI Gene ID: 120356739

neXtProt AC: NX_Q96E66
Chr Location

chr11:72080337-72096895 (+) GRCh38

Human Ortholog

LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
Synonyms

CFAP111, DFNB63, LRRC51, LRRC51-TOMT, TOMT
Links

HGNC:25033

NCBI Gene ID: 220074

neXtProt AC: NX_Q8WZ04, NX_Q96E66
Chr Location

11q13.4; chr11:72080331-72110782 (+) GRCh38

Human Ortholog

TOMT, transmembrane O-methyltransferase
Synonyms

COMT2
Links

HGNC:55527

NCBI Gene ID: 120356740
Chr Location

chr11:72105924-72109596 (+) GRCh38

MGI Vertebrate Homology

Lrrc51 stringent orthology
3 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRRC51, LRTOMT, TOMT
Gene Tree

Lrrc51

Diseases

1 with human LRTOMT associations

Human Disease

Mouse Models

autosomal recessive nonsyndromic deafness 63

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

27
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Lrrc51
Incidental Mutations

CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

12
cDNA Data

5
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN lrrc51

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All Sequences

68
RefSeq

20
UniProt

4
CCDS

CCDS52331.1, CCDS52332.1

Ensembl

ENSMUSG00000064307 (Evidence)
NCBI Gene

69358

			Length	Strain/Species	Flank
genomic	ENSMUSG00000064307	Ensembl Gene Model \| MGI Sequence Detail	20912	C57BL/6J	± kb
transcript	ENSMUST00000106968	Ensembl \| MGI Sequence Detail	766	Not Applicable
polypeptide	ENSMUSP00000102581	Ensembl \| MGI Sequence Detail	192	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000033471 leucine-rich repeat-containing protein 51

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

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All nucleic 5

cDNA 5

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 1

Phenotypes 17
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:240319 Stauber M, et al., Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017 Mar 15;423(2):170-188

TSS for Lrrc51:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73891	Chr7:101583536-101583551 (-)	-442 bp
Tssr73890	Chr7:101583114-101583125 (-)	-18 bp
Tssr73889	Chr7:101583022-101583104 (-)	39 bp
Tssr73888	Chr7:101582987-101583013 (-)	102 bp
Tssr73887	Chr7:101570958-101571000 (-)	12,123 bp
Tssr73886	Chr7:101570393-101570437 (-)	12,687 bp
Tssr73885	Chr7:101570382-101570388 (-)	12,717 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23