Lrrc51 Gene Detail

Summary

• Symbol
  Lrrc51
• Name
  leucine rich repeat containing 51
• Synonyms
  1700008D07Rik, Lrtomt

• Feature Type
  protein coding gene
• IDs
  MGI:1916608
  NCBI Gene: 69358
• Gene Overview
  MyGene.info: LRTOMT
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr7:101912984-101933895 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    20912 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 54.69 cM, cytoband F1
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing

• Vertebrate Orthologs
  6

• Human Ortholog
  LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
  Orthology source: HGNC
• Synonyms
  CFAP111, DFNB63, LRRC51
• Links
  HGNC:25033

  NCBI Gene ID: 220074

  neXtProt AC: NX_Q8WZ04, NX_Q96E66

  UniProt: Q8WZ04, Q96E66

  
  
• Chr Location
  11q13.4; chr11:72079982-72110782 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 17066
  1 mouse;1 rat;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: LRTOMT
• Gene Tree
  Lrrc51
  

Human Diseases

• Diseases
  1 with human LRTOMT associations

Human Disease

Mouse Models

autosomal recessive nonsyndromic deafness 63

IDs

autosomal recessive nonsyndromic deafness 63      

DOID:0110515
ICD10CM:H90.3
OMIM:611451

View 1 model

Mouse Models

Human Disease Modeled: autosomal recessive nonsyndromic deafness 63

Allelic Composition	Genetic Background	Reference	Phenotypes
Tomtm1Btlr/Tomtm1Btlr	C57BL/6J-Tomt^m1Btlr	J:137493	View

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  16 phenotype references
  

• All Mutations and Alleles
  36
• Chemically induced (other)
  1
• Gene trapped
  31
• Radiation induced
  1
• Targeted
  3
• Genomic Mutations
  2 involving Lrrc51
• Incidental Mutations
  CvDC
• Find Mice (IMSR)
  19 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

• External Resources
  FuncBase

Expression

• Assay Results
  23
• Tissues
  12
• cDNA Data
  5
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN lrrc51

Interactions

• Lrrc51 interacts with 78 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  66
• RefSeq
  18
• UniProt
  4
• CCDS
  CCDS52331.1, CCDS52332.1

• VEGA
  OTTMUSG00000023365 (Evidence)
• Ensembl
  ENSMUSG00000064307 (Evidence)
• NCBI Gene
  69358

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000023365	VEGA Gene Model | MGI Sequence Detail	20912	C57BL/6J
transcript	OTTMUST00000056687	VEGA | MGI Sequence Detail	766	Not Applicable
polypeptide	OTTMUSP00000027270	VEGA | MGI Sequence Detail	192	Not Applicable

Polymorphisms

• SNPs within 2kb
  107 from dbSNP Build 142

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000033471 leucine-rich repeat-containing protein 51
  (term hierarchy)
• InterPro Domains
  IPR001611 Leucine-rich repeat
  IPR032675 Leucine-rich repeat domain superfamily

Molecular
Reagents

• All nucleic 5

  cDNA 5

  
  

  Microarray probesets 3

References

• Summaries
  All 39

  Developmental Gene Expression 3

  Gene Ontology 1

  Phenotypes 16
• Earliest
  J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
• Latest
  J:240319 Stauber M, et al., Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017 Mar 15;423(2):170-188