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Hmgb4 Gene Detail
Summary
  • Symbol
    Hmgb4
  • Name
    high-mobility group box 4
  • Synonyms
    1700001F22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916567
    NCBI Gene: 69317
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:128154005-128154688 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 61.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916567
 protein coding gene Chr4:128154005-128154750 (-)
129S1/SvImJ ENSMUSG00200013626
 protein coding gene Chr4:121593888-121594633 (-)
A/J ENSMUSG00195039864
 protein coding gene Chr4:122934464-122935209 (-)
AKR/J ENSMUSG00220020172
 protein coding gene Chr4:121919889-121920634 (-)
BALB/cJ ENSMUSG00180045092
 protein coding gene Chr4:120568156-120568901 (-)
C3H/HeJ ENSMUSG00175020981
 protein coding gene Chr4:121580828-121581573 (-)
C57BL/6NJ ENSMUSG00215050114
 protein coding gene Chr4:123076313-123077058 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026499
 protein coding gene Chr4:118055082-118055830 (-)
CAST/EiJ ENSTCUG00005045261
 protein coding gene Chr4:122466339-122467084 (-)
CBA/J ENSMUSG00210051483
 protein coding gene Chr4:121209690-121210435 (-)
DBA/2J ENSMUSG00185050243
 protein coding gene Chr4:122742250-122742995 (-)
FVB/NJ ENSMUSG00205015869
 protein coding gene Chr4:120965721-120966466 (-)
JF1/MsJ ENSUMUG00000011304
 protein coding gene Chr4:123385472-123386217 (-)
LP/J ENSMUSG00230029003
 protein coding gene Chr4:126531439-126532184 (-)
NOD/ShiLtJ ENSMUSG00190031785
 protein coding gene Chr4:120970740-120971485 (-)
NZO/HlLtJ ENSMUSG00225015283
 protein coding gene Chr4:132447487-132448232 (-)
PWK/PhJ ENSLUMG00010041010
 protein coding gene Chr4:120423685-120424430 (-)
SPRET/EiJ ENSMSPG00010040892
 protein coding gene Chr4:122503013-122503758 (-)
WSB/EiJ ENSIUOG00005041720
 protein coding gene Chr4:120823227-120823972 (-)



Homology
more
  • Human Ortholog
    HMGB4, high mobility group box 4
  • Vertebrate Orthologs
    16
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGB4, high mobility group box 4
  • Synonyms
    dJ1007G16.5
  • Links
    NCBI Gene ID: 127540
    UniProt: Q8WW32

  • Chr Location
    1p35.1; chr1:33860475-33864791 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Male mice homozygous for a null allele exhibit normal fecundity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    702
  • Tissues
    102
  • cDNA Data
    8
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69317 NCBI Gene Model | MGI Sequence Detail 684 C57BL/6J ±  kb
transcript NM_027036 RefSeq | MGI Sequence Detail 697 Not Specified  
polypeptide Q6P8W9 UniProt | EBI | MGI Sequence Detail 181 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 8
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140242
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory