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Hmgb4 Gene Detail
Summary
  • Symbol
    Hmgb4
  • Name
    high-mobility group box 4
  • Synonyms
    1700001F22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916567
    NCBI Gene: 69317
  • Gene Overview
    MyGene.info: HMGB4
Location & Maps
more
  • Sequence Map
    Chr4:128260212-128260957 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      746 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 61.97 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HMGB4, high mobility group box 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HMGB4, high mobility group box 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ1007G16.5
  • Links
    NCBI Gene ID: 127540
    neXtProt AC: NX_Q8WW32

  • Chr Location
    1p35.1; chr1:33860475-33864791 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Hmgb4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009452 VEGA Gene Model | MGI Sequence Detail 746 C57BL/6J ±  kb
transcript OTTMUST00000021529 VEGA | MGI Sequence Detail 746 Not Applicable  
polypeptide OTTMUSP00000009835 VEGA | MGI Sequence Detail 181 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    50 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008634 high mobility group protein B4
  • InterPro Domains
    IPR009071 High mobility group box domain
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2140242
References
more
  • Summaries
    All 26
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:171052 Itou J, et al., HMGB factors are required for posterior digit development through integrating signaling pathway activities. Dev Dyn. 2011 May;240(5):1151-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory