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Pacrg Gene Detail
Summary
  • Symbol
    Pacrg
  • Name
    PARK2 co-regulated
  • Synonyms
    1700008H23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916560
    NCBI Gene: 69310
  • Gene Overview
    MyGene.info: PACRG
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:10403009-10840191 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 7.80 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1340 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916560
protein coding gene Chr17:10403009-10840311 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023141
protein coding gene Chr17:8002386-8446119 (-)
A/J MGP_AJ_G0023109
protein coding gene Chr17:7900263-8347753 (-)
AKR/J MGP_AKRJ_G0023073
protein coding gene Chr17:7641296-8107605 (-)
BALB/cJ MGP_BALBcJ_G0023109
protein coding gene Chr17:7684052-8127623 (-)
C3H/HeJ MGP_C3HHeJ_G0022872
protein coding gene Chr17:7929828-8378560 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023552
protein coding gene Chr17:8307512-8776892 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021056
protein coding gene Chr17:6068028-6515260 (+)
CAST/EiJ MGP_CASTEiJ_G0022386
protein coding gene Chr17:7957829-8415692 (-)
CBA/J MGP_CBAJ_G0022844
protein coding gene Chr17:8626859-9113345 (-)
DBA/2J MGP_DBA2J_G0022977
protein coding gene Chr17:7541087-7986185 (-)
FVB/NJ MGP_FVBNJ_G0022947
protein coding gene Chr17:7497296-7935840 (-)
LP/J MGP_LPJ_G0023049
protein coding gene Chr17:7782948-8241294 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022966
protein coding gene Chr17:8297924-8777109 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023578
protein coding gene Chr17:7948705-8396508 (-)
PWK/PhJ MGP_PWKPhJ_G0022134
protein coding gene Chr17:7232456-7678406 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021964
protein coding gene Chr17:7294747-7749031 (-)
WSB/EiJ MGP_WSBEiJ_G0022443
protein coding gene Chr17:8251775-8707552 (-)



Homology
more
  • Human Ortholog
    PACRG, parkin coregulated
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PACRG, parkin coregulated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUP, HAK005771, PARK2CRG
  • Links
    NCBI Gene ID: 135138
    neXtProt AC: NX_Q96M98
    UniProt: Q96M98

  • Chr Location
    6q26; chr6:162726870-163315492 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 16212
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PACRG
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    97 phenotype references
Along with altered levele of the Qki transcript, both Pacrg and Park2 are inactivated as a result of a 1.85 Mb deletion in the in the quaking mouse. The quaking mouse is a spontaneous dysmyelinating mutant that demonstrates abnormal locomotion, tremor, and tonic-clonic seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69310 NCBI Gene Model | MGI Sequence Detail 437183 C57BL/6J ±  kb
transcript NM_027032 RefSeq | MGI Sequence Detail 1355 C57BL/6  
polypeptide Q9DAK2 UniProt | EBI | MGI Sequence Detail 241 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 3
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 131
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 97
  • Earliest
    J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
  • Latest
    J:249096 Suiko T, et al., Expression of Quaking RNA-Binding Protein in the Adult and Developing Mouse Retina. PLoS One. 2016;11(5):e0156033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory