About   Help   FAQ
Dcps
Gene Detail
Symbol

Name
ID
Dcps
decapping enzyme, scavenger
MGI:1916555
Synonyms
1700001E16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
19.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:35124408-35176061 bp, - strand
From VEGA annotation of GRCm38

  51654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: scavenger mRNA decapping enzyme DcpS
Gene Tree: Dcps

Human
homologs
Human Homolog DCPS, decapping enzyme, scavenger
NCBI Gene ID 28960
neXtProt AC  NX_Q96C86
Human Synonyms  DCS1, HINT5, HINT-5, HSL1
Human Chr (Location)  11q24.2; chr11:126303752-126345749 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
A mutant mouse line was generated from gene-trapped ES cells, but no phenotypic information is available.
 
Interactions
Dcps interacts with 60 markers (Mir16-1, Mir22, Mir101c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cellular response to menadione, deadenylation-dependent decapping of nuclear-transcribed mRNA, ...
Component cytoplasm, mitochondrion, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (242)    Tissues (26)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 242
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031937 (Evidence)
Ensembl Gene ModelENSMUSG00000032040 (Evidence)
Entrez Gene69305 (Evidence)
NIA Mouse Gene IndexU030661
EC3.6.1.59
PDB1VLR
Consensus CDS ProjectCCDS22957.1
International Mouse Knockout Project StatusDcps
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031937 VEGA Gene Model | MGI Sequence Detail 51654 C57BL/6J ±  kb
transcript OTTMUST00000079214 VEGA | MGI Sequence Detail 1274 Not Applicable 
polypeptide OTTMUSP00000042219 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019808 Histidine triad, conserved site
InterPro IPR011146 HIT-like domain
InterPro IPR008594 Scavenger mRNA decapping enzyme DcpS/DCS2
InterPro IPR011145 Scavenger mRNA decapping enzyme, N-terminal
Protein Ontology PR:000006320 scavenger mRNA-decapping enzyme DcpS
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201100 Van Meerbeke JP, et al., The DcpS inhibitor RG3039 improves motor function in SMA mice. Hum Mol Genet. 2013 Oct 15;22(20):4074-83
All references(31)
Other
accession IDs
MGI:2142921

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory