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Rmc1 Gene Detail
Summary
  • Symbol
    Rmc1
  • Name
    regulator of MON1-CCZ1
  • Synonyms
    2400010D15Rik, 3110002H16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916528
    NCBI Gene: 76482
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:12301774-12323715 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 6.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    868 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916528
 protein coding gene Chr18:12301746-12331732 (+)
129S1/SvImJ ENSMUSG00200023470
 protein coding gene Chr18:9231329-9253024 (+)
A/J ENSMUSG00195008213
 protein coding gene Chr18:9429688-9451304 (+)
AKR/J ENSMUSG00220018961
 protein coding gene Chr18:9424160-9445776 (+)
BALB/cJ ENSMUSG00180005283
 protein coding gene Chr18:9877816-9899048 (+)
C3H/HeJ ENSMUSG00175007416
 protein coding gene Chr18:9417138-9438368 (+)
C57BL/6NJ ENSMUSG00215010210
 protein coding gene Chr18:9140532-9161812 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022002
 protein coding gene Chr18:8752104-8774607 (+)
CAST/EiJ ENSTCUG00005016891
 protein coding gene Chr18:9200000-9221762 (+)
CBA/J ENSMUSG00210021446
 protein coding gene Chr18:9425997-9447229 (+)
DBA/2J ENSMUSG00185029025
 protein coding gene Chr18:9435397-9456677 (+)
FVB/NJ ENSMUSG00205031944
 protein coding gene Chr18:9203863-9225481 (+)
JF1/MsJ ENSUMUG00000035734
 protein coding gene Chr18:9471032-9492736 (+)
LP/J ENSMUSG00230011109
 protein coding gene Chr18:11475471-11508031 (+)
NOD/ShiLtJ ENSMUSG00190009355
 protein coding gene Chr18:9199922-9221202 (+)
NZO/HlLtJ ENSMUSG00225027888
 protein coding gene Chr18:11413380-11445940 (+)
PWK/PhJ ENSLUMG00010009043
 protein coding gene Chr18:9689584-9711348 (+)
SPRET/EiJ ENSMSPG00010010831
 protein coding gene Chr18:9349215-9369551 (+)
WSB/EiJ ENSIUOG00005024814
 protein coding gene Chr18:9302396-9324211 (+)



Homology
more
  • Human Ortholog
    RMC1, regulator of MON1-CCZ1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RMC1, regulator of MON1-CCZ1
  • Synonyms
    C18orf8, HsT2591, Mic-1, MIC1, WDR98
  • Links
    NCBI Gene ID: 29919
    UniProt: Q96DM3

  • Chr Location
    18q11.2; chr18:23503470-23531822 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    14
  • cDNA Data
    10
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024410 Ensembl Gene Model | MGI Sequence Detail 21942 C57BL/6J ±  kb
transcript ENSMUST00000025276 Ensembl | MGI Sequence Detail 2170 Not Applicable  
polypeptide ENSMUSP00000025276 Ensembl | MGI Sequence Detail 657 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000059995 regulator of MON1-CCZ1 complex
    (term hierarchy)
  • InterPro Domains
    IPR040371 Regulator of MON1-CCZ1 complex
    IPR009755 Regulator of MON1-CCZ1 complex, C-terminal
    IPR049040 Regulator of MON1-CCZ1 complex, N-terminal
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
  • GlyGen
    Q8VC42 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923732, MGI:6156537
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:41469 Loftus SK, et al., Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene [see comments]. Science. 1997 Jul 11;277(5323):232-5
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory