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Tmt1a Gene Detail
Summary
  • Symbol
    Tmt1a
  • Name
    thiol methyltransferase 1A1
  • Synonyms
    2210414H16Rik, 3300001H21Rik, Mettl7a, Mettl7a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916523
    NCBI Gene: 70152
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:100202021-100226543 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.25 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916523
protein coding gene Chr15:100201969-100227882 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0022308
protein coding gene Chr15:98160588-98172147 (+)
AKR/J MGP_AKRJ_G0022284
protein coding gene Chr15:101187474-101204924 (+)
BALB/cJ MGP_BALBcJ_G0022315
protein coding gene Chr15:98334521-98350713 (+)
C3H/HeJ MGP_C3HHeJ_G0022082
protein coding gene Chr15:101259521-101303256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022759
protein coding gene Chr15:106053334-106062080 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020286
protein coding gene Chr15:94047034-94052464 (+)
CAST/EiJ MGP_CASTEiJ_G0021609
protein coding gene Chr15:102136933-102149109 (+)
CBA/J MGP_CBAJ_G0022052
protein coding gene Chr15:109766133-109783372 (+)
DBA/2J MGP_DBA2J_G0022178
protein coding gene Chr15:97580121-97594027 (+)
FVB/NJ MGP_FVBNJ_G0022158
protein coding gene Chr15:96573698-96582308 (+)
LP/J MGP_LPJ_G0022250
protein coding gene Chr15:102380959-102398479 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022179
protein coding gene Chr15:113517201-113527055 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022775
protein coding gene Chr15:101285379-101294896 (+)
PWK/PhJ MGP_PWKPhJ_G0021348
protein coding gene Chr15:97770017-97778796 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0021660
protein coding gene Chr15:101819537-101827958 (+)



Homology
more
  • Human Ortholog
    TMT1A, thiol methyltransferase 1A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMT1A, thiol methyltransferase 1A
  • Synonyms
    AAMB, AAM-B, METTL7A
  • Links
    NCBI Gene ID: 25840
    neXtProt AC: NX_Q9H8H3
    UniProt: Q9H8H3

  • Chr Location
    12q13.12; chr12:50923472-50932510 (+)  GRCh38

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Tmt1a
  • Incidental Mutations
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054619 Ensembl Gene Model | MGI Sequence Detail 24523 C57BL/6J ±  kb
transcript ENSMUST00000067752 Ensembl | MGI Sequence Detail 1946 Not Applicable  
polypeptide ENSMUSP00000065271 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    11 Sequences
  • InterPro Domains
    IPR013216 Methyltransferase type 11
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 7
Other
Accession IDs
less
MGI:1917402
References
more
  • Summaries
    All 48
    Diseases 1
    Gene Ontology 2
    Phenotypes 26
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:327245 Briata P, et al., LncRNA EPR-induced METTL7A1 modulates target gene translation. Nucleic Acids Res. 2022 Jul 22;50(13):7608-7622

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory