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Ing2
Gene Detail
 Symbol
Name
ID
Ing2
inhibitor of growth family, member 2
MGI:1916510
Synonyms 2810011M06Rik, Ing1l, ING2, P33ING2
Feature Type protein coding gene
Genetic Map
Chromosome 8
26.87 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:47667178-47675556 bp, - strand
From VEGA annotation of GRCm38

  8379 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20388  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: uncharacterized conserved protein
Gene Tree: Ing2

Human
homologs
Human Homolog ING2, inhibitor of growth family, member 2
NCBI Gene ID 3622
neXtProt AC  NX_Q9H160
Human Synonyms  ING1L, p33ING2
Human Chr (Location)  4q35.1; chr4:183505067-183512269 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes impaired spermatogenesis and male infertility associated with teratozoospermia, seminiferous tubule degeneration, germ cell depletion, arrest of male meiosis and enhanced testicular apoptosis, and leads to an increased incidence of soft tissue sarcomas.
 
Phenotype Images(3)
Interactions
Ing2 interacts with 215 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process chromatin modification, male germ-line stem cell asymmetric division, ...
Component CCAAT-binding factor complex, nucleus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (188)    Tissues (167)    Images (5)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 180
RT-PCR 8
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017299 (Evidence)
Ensembl Gene ModelENSMUSG00000063049 (Evidence)
Entrez Gene69260 (Evidence)
UniGene430733
DFCITC1583387
DoTSDT.91360490, DT.99868000
NIA Mouse Gene IndexU029798
PDB1WES, 2G6Q
Consensus CDS ProjectCCDS22298.1
International Mouse Knockout Project StatusIng2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017299 VEGA Gene Model | MGI Sequence Detail 8379 C57BL/6J ±  kb
transcript OTTMUST00000041966 VEGA | MGI Sequence Detail 2812 Not Applicable 
polypeptide OTTMUSP00000018871 VEGA | MGI Sequence Detail 281 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024610 Inhibitor of growth protein, N-terminal
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000009034 inhibitor of growth protein 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:167311 Saito M, et al., Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS One. 2010;5(11):e15541
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory