About   Help   FAQ
Elf2 Gene Detail
Summary
  • Symbol
    Elf2
  • Name
    E74-like factor 2
  • Synonyms
    2610036A20Rik, A230104O07Rik, NERF-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916507
    NCBI Gene: 69257
Location & Maps
more
  • Sequence Map
    Chr3:51252720-51340663 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87944 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ELF2, E74-like factor 2 (ets domain transcription factor)
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ELF2, E74-like factor 2 (ets domain transcription factor)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EU32, NERF, NERF-1A, NERF-1a,b, NERF-1B, NERF-2
  • Links
    NCBI Gene ID: 1998
    neXtProt AC: NX_Q15723

  • Chr Location
    4q28; chr4:139057717-139177218 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
  • All Mutations and Alleles
    22
  • Gene trapped
    18
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Elf2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051593 VEGA Gene Model | MGI Sequence Detail 87944 C57BL/6J ±  kb
transcript OTTMUST00000050295 VEGA | MGI Sequence Detail 5919 Not Applicable  
polypeptide OTTMUSP00000023461 VEGA | MGI Sequence Detail 593 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    605 from dbSNP Build 137
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000007021 ETS-related transcription factor Elf-2
  • InterPro Domains
    IPR000418 Ets domain
    IPR022084 Transcription factor Elf, N-terminal
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 23
    cDNA 21
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139969, MGI:2140032
References
more
  • Summaries
    All 44
    Developmental Gene Expression 11
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:115181 Wilkinson DA, et al., Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia. Leukemia. 1997 Jan;11(1):86-96
  • Latest
    J:179397 Schachterle W, et al., ETS-dependent regulation of a distal Gata4 cardiac enhancer. Dev Biol. 2012 Jan 15;361(2):439-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory