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Hspb2
Gene Detail
 Symbol
Name
ID
Hspb2
heat shock protein 2
MGI:1916503
Synonyms 27kDa, 2810021G24Rik, HSP27, MKBP
Feature Type protein coding gene
Genetic Map
Chromosome 9
27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:50751072-50752354 bp, - strand
From NCBI annotation of GRCm38

  1283 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Sm_HSP_B1
Gene Tree: Hspb2

Human
homologs
Human Homolog HSPB2, heat shock 27kDa protein 2
NCBI Gene ID 3316
neXtProt AC  NX_Q16082
Human Synonyms  Hs.78846, HSP27, LOH11CR1K, MKBP
Human Chr (Location)  11q22-q23; chr11:111912736-111914093 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a conditional allele activated in the heart exhibit reduced state 3 mitochondrial respiration and ATP production following transverse aortic constriction despite normal cardiac hypertrophic response.
 
Interactions
Hspb2 interacts with 50 markers (Mir92b, Mir98, Mir150, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process response to heat, response to stress, ...
Component cytoplasm, nucleus
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (111)    Tissues (11)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 111
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000038086 (Evidence)
Entrez Gene69253 (Evidence)
UniGene1980
DFCITC1586498, TC1590136
DoTSDT.91337324, DT.94395576
NIA Mouse Gene IndexU030848
Consensus CDS ProjectCCDS23171.1
International Mouse Knockout Project StatusHspb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 69253 NCBI Gene Model | MGI Sequence Detail 1283 C57BL/6J ±  kb
transcript NM_024441 RefSeq | MGI Sequence Detail 910 C57BL/6 
polypeptide Q99PR8 UniProt | EBI | MGI Sequence Detail 182 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001436 Alpha crystallin/Heat shock protein
InterPro IPR002068 Alpha crystallin/Hsp20 domain
InterPro IPR008978 HSP20-like chaperone
Protein Ontology PR:000008816 heat shock protein beta-2
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201930 Andley UP, et al., Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins alphaA- and alphaB-crystallin. Biochemistry. 2013 Apr 30;52(17):2933-48
All references(68)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory