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Selenot Gene Detail
Summary
  • Symbol
    Selenot
  • Name
    selenoprotein T
  • Synonyms
    2810407C02Rik, 5730408P04Rik, Selt, SelT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916477
    NCBI Gene: 69227
  • Gene Overview
    MyGene.info: SELENOT
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:58576636-58593133 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 28.61 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916477
protein coding gene Chr3:58576636-58593544 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027237
protein coding gene Chr3:57421949-57439392 (+)
A/J MGP_AJ_G0027197
protein coding gene Chr3:55634264-55649226 (+)
AKR/J MGP_AKRJ_G0027167
protein coding gene Chr3:56778094-56797526 (+)
BALB/cJ MGP_BALBcJ_G0027210
protein coding gene Chr3:55445491-55461881 (+)
C3H/HeJ MGP_C3HHeJ_G0026953
protein coding gene Chr3:56998782-57015746 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027656
protein coding gene Chr3:59534045-59551684 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025010
protein coding gene Chr3:51984957-52001645 (+)
CAST/EiJ MGP_CASTEiJ_G0026405
protein coding gene Chr3:57163154-57182675 (+)
CBA/J MGP_CBAJ_G0026929
protein coding gene Chr3:61508395-61528312 (+)
DBA/2J MGP_DBA2J_G0027063
protein coding gene Chr3:55129410-55146335 (+)
FVB/NJ MGP_FVBNJ_G0027031
protein coding gene Chr3:54101236-54116917 (+)
LP/J MGP_LPJ_G0027175
protein coding gene Chr3:58174433-58190934 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027049
protein coding gene Chr3:65644700-65655392 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027714
protein coding gene Chr3:56735075-56751598 (+)
PWK/PhJ MGP_PWKPhJ_G0026137
protein coding gene Chr3:54781338-54798529 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025950
protein coding gene Chr3:56410242-56428739 (+)
WSB/EiJ MGP_WSBEiJ_G0026479
protein coding gene Chr3:56814521-56832893 (+)



Homology
more
  • Human Ortholog
    SELENOT, selenoprotein T
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SELENOT, selenoprotein T
    Orthology source: HomoloGene
  • Synonyms
    SELT
  • Links
    NCBI Gene ID: 51714
    neXtProt AC: NX_P62341
    UniProt: P62341

  • Chr Location
    3q25.1; chr3:150603279-150630447 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in beta cells exhibit impaired glucose tolerance, increased circulating glucose levels, decreased circulating insulin levels, decreased insulin secretion and an increase in smaller islets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075700 Ensembl Gene Model | MGI Sequence Detail 16498 C57BL/6J ±  kb
transcript ENSMUST00000107924 Ensembl | MGI Sequence Detail 3157 Not Applicable  
polypeptide ENSMUSP00000103557 Ensembl | MGI Sequence Detail 195 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 6
Other
Accession IDs
less
MGI:1917762
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:58830 Kryukov GV, et al., New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. J Biol Chem. 1999 Nov 26;274(48):33888-97
  • Latest
    J:252321 Hamieh A, et al., Selenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion. EMBO Rep. 2017 Nov;18(11):1935-1946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory