Ddah1 MGI Mouse Gene Detail - MGI:1916469 - dimethylarginine dimethylaminohydrolase 1

Symbol

Ddah1
Name

dimethylarginine dimethylaminohydrolase 1
Synonyms

2410006N07Rik, 2510015N06Rik

Feature Type

protein coding gene
IDs

MGI:1916469
NCBI Gene: 69219
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr3:145464447-145600032 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 70.63 cM, cytoband H3
Mapping Data

3 experiments

SNPs within 2kb

683 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916469	protein coding gene	Chr3:145464430-145600032 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027962	protein coding gene	Chr3:149212668-149349101 (+)
A/J	MGP_AJ_G0027921	protein coding gene	Chr3:143892526-144023978 (+)
AKR/J	MGP_AKRJ_G0027887	protein coding gene	Chr3:147706144-147854358 (+)
BALB/cJ	MGP_BALBcJ_G0027933	protein coding gene	Chr3:143703617-143839665 (+)
C3H/HeJ	MGP_C3HHeJ_G0027663	protein coding gene	Chr3:148084150-148223675 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028376	protein coding gene	Chr3:154284286-154416095 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025715	protein coding gene	Chr3:138967294-139100324 (+)
CAST/EiJ	MGP_CASTEiJ_G0027116	protein coding gene	Chr3:148035174-148178061 (+)
CBA/J	MGP_CBAJ_G0027638	protein coding gene	Chr3:159693594-159841565 (+)
DBA/2J	MGP_DBA2J_G0027778	protein coding gene	Chr3:143033802-143166710 (+)
FVB/NJ	MGP_FVBNJ_G0027745	protein coding gene	Chr3:140441669-140577999 (+)
LP/J	MGP_LPJ_G0027889	protein coding gene	Chr3:150601023-150744371 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027778	protein coding gene	Chr3:168000859-168146215 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028435	protein coding gene	Chr3:147306828-147449706 (+)
PWK/PhJ	MGP_PWKPhJ_G0026839	protein coding gene	Chr3:142881713-143016089 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026667	protein coding gene	Chr3:145472523-145603527 (+)
WSB/EiJ	MGP_WSBEiJ_G0027196	protein coding gene	Chr3:148259005-148402616 (+)

Human Ortholog

DDAH1, dimethylarginine dimethylaminohydrolase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDAH1, dimethylarginine dimethylaminohydrolase 1
Synonyms

DDAH, DDAH-1, DDAHI, HEL-S-16
Links

HGNC:2715

NCBI Gene ID: 23576

neXtProt AC: NX_O94760

UniProt: O94760
Chr Location

1p22.3; chr1:85318485-85578363 (-) GRCh38.p7

Alliance of Genome Resources

Ddah1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDAH1
Gene Tree

Ddah1

Diseases

2 with human DDAH1 associations

				Human Disease	Mouse Models
				cardiovascular system disease IDs cardiovascular system disease DOID:1287 DOID:73 ICD9CM:429.2 MESH:D002318 NCI:C2931 UMLS_CUI:C0007222
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

24 phenotypes from 6 alleles in 7 genetic backgrounds
8 phenotypes from multigenic genotypes
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Gene trapped

3
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

1 involving Ddah1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Both heterozygous and homozygous inactivation of this gene leads to increased plasma asymmetrical dimethylarginine (ADMA) levels, reduced cardiovascular nitric oxide production, and increased blood pressure.

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

883
Tissues

138
cDNA Data

15
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddah1

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Ddah1 interacts with 287 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

54
RefSeq

8
UniProt

3
CCDS

CCDS17896.1

Ensembl

ENSMUSG00000028194 (Evidence)
NCBI Gene

69219

			Length	Strain/Species	Flank
genomic	69219	NCBI Gene Model \| MGI Sequence Detail	135586	C57BL/6J	± kb
transcript	NM_026993	RefSeq \| MGI Sequence Detail	3747	C57BL/6
polypeptide	Q9CWS0	UniProt \| EBI \| MGI Sequence Detail	285	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006338 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

(term hierarchy)
EC

3.5.3.18
InterPro Domains

IPR033199 Dimethylarginine dimethylaminohydrolase

IPR033197 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

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All nucleic 18

cDNA 16

Primer pair 1

Other 1

Microarray probesets 9

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MGI:1917484, MGI:2139846, MGI:2139962

Summaries

All 73

Developmental Gene Expression 7

Diseases 1

Gene Ontology 7

Phenotypes 36
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:320493 Xie Z, et al., Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation. Nat Commun. 2022 Jan 10;13(1):50

TSS for Ddah1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32294	Chr3:145463014-145463022 (+)	-1,429 bp
Tssr32295	Chr3:145464429-145464440 (+)	-12 bp
Tssr32296	Chr3:145464444-145464449 (+)	0 bp
Tssr1078	Chr3:145464453-145464456 (+)	8 bp
Tssr32297	Chr3:145464473-145464493 (+)	36 bp
Tssr32298	Chr3:145464505-145464519 (+)	65 bp
Tssr1079	Chr3:145464534-145464539 (+)	90 bp
Tssr1080	Chr3:145464542-145464549 (+)	99 bp
Tssr1081	Chr3:145464550-145464557 (+)	107 bp
Tssr1082	Chr3:145464579-145464595 (+)	140 bp
Tssr32299	Chr3:145464664-145464706 (+)	238 bp
Tssr32300	Chr3:145464718-145464739 (+)	282 bp
Tssr32301	Chr3:145516202-145516220 (+)	51,764 bp
Tssr32302	Chr3:145516228-145516249 (+)	51,792 bp
Tssr32303	Chr3:145533454-145533486 (+)	69,023 bp
Tssr32305	Chr3:145597253-145597269 (+)	132,814 bp
Tssr32306	Chr3:145597356-145597370 (+)	132,916 bp
Tssr32307	Chr3:145597401-145597413 (+)	132,960 bp
Tssr32308	Chr3:145597748-145597764 (+)	133,309 bp
Tssr32309	Chr3:145597770-145597781 (+)	133,329 bp
Tssr32310	Chr3:145598527-145598532 (+)	134,083 bp
Tssr32311	Chr3:145599711-145599721 (+)	135,269 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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