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Ddah1 Gene Detail
Summary
  • Symbol
    Ddah1
  • Name
    dimethylarginine dimethylaminohydrolase 1
  • Synonyms
    2410006N07Rik, 2510015N06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916469
    NCBI Gene: 69219
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr3:145758675-145894277 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      135603 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 70.63 cM, cytoband H3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DDAH1, dimethylarginine dimethylaminohydrolase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDAH1, dimethylarginine dimethylaminohydrolase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DDAH, DDAH-1, DDAHI, HEL-S-16
  • Links
    NCBI Gene ID: 23576
    neXtProt AC: NX_O94760
    UniProt: O94760

  • Chr Location
    1p22.3; chr1:85318485-85578363 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 6 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Both heterozygous and homozygous inactivation of this gene leads to increased plasma asymmetrical dimethylarginine (ADMA) levels, reduced cardiovascular nitric oxide production, and increased blood pressure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    173
  • Tissues
    137
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029461 VEGA Gene Model | MGI Sequence Detail 135603 C57BL/6J ±  kb
    transcript OTTMUST00000073001 VEGA | MGI Sequence Detail 3764 Not Applicable  
    polypeptide OTTMUSP00000037729 VEGA | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      683 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006338 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
      (term hierarchy)
    • EC
      3.5.3.18
    • InterPro Domains
      IPR033199 Dimethylarginine dimethylaminohydrolase/arginine deiminase
      IPR033197 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1917484, MGI:2139846, MGI:2139962
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 6
      Phenotypes 29
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:234529 Dowsett L, et al., Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis. Circulation. 2015 Jun 23;131(25):2217-25
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    06/12/2018
    MGI 6.12     		The Jackson Laboratory