Ddah1
Gene Detail

Symbol Name ID

Ddah1 dimethylarginine dimethylaminohydrolase 1 MGI:1916469

Synonyms

2410006N07Rik, 2510015N06Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 3

70.63 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:145758675-145894277 bp, + strand From VEGA annotation of GRCm38   135603 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8120  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: N(G),N(G)-dimethylarginine dimethylaminohydrolase
Gene Tree: Ddah1

Human homologs

Human Homolog		DDAH1, dimethylarginine dimethylaminohydrolase 1
NCBI Gene ID		23576
neXtProt AC		NX_O94760
Human Synonyms		DDAH, HEL-S-16
Human Chr (Location)		1p22; chr1:85318485-85578363 (-)  GRCh38

Alleles and phenotypes

All alleles(9) : Gene trapped(4) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit lethality at E2. Mice heterozygous for a knock-out allele exhibit abnormal cardiovascular physiology. Mice with a conditional KO in endothelial cells have elevated blood pressure.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	arginine metabolic process, citrulline metabolic process, ...
Component	cytoplasm, extracellular vesicular exosome, ...
Function	amino acid binding, dimethylargininase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (173)    Tissues (135)    Images (30)
Theiler Stages: 9, 13, 15, 17, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	170

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(15)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000029461 (Evidence)
Ensembl Gene Model	ENSMUSG00000028194 (Evidence)
Entrez Gene	69219 (Evidence)
DFCI	TC1579084, TC1655776
DoTS	DT.101186081, DT.94266843
NIA Mouse Gene Index	U003950
EC	3.5.3.18
Consensus CDS Project	CCDS17896.1
International Mouse Knockout Project Status	Ddah1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029461	VEGA Gene Model | MGI Sequence Detail	135603	C57BL/6J
transcript	OTTMUST00000073001	VEGA | MGI Sequence Detail	3764	Not Applicable
polypeptide	OTTMUSP00000037729	VEGA | MGI Sequence Detail	285	Not Applicable

All sequences(45) RefSeq(6) UniProt(3)

Polymorphisms

SNPs within 2kb(690 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003198	Amidinotransferase
Protein Ontology	PR:000006338	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209681 Zhang P, et al., DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis. PLoS One. 2013;8(11):e79444
All references(52)

Other accession IDs

MGI:1917484, MGI:2139846, MGI:2139962