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Ddah1
Gene Detail
Symbol

Name
ID
Ddah1
dimethylarginine dimethylaminohydrolase 1
MGI:1916469
Synonyms
2410006N07Rik, 2510015N06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
70.63 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:145758675-145894277 bp, + strand
From VEGA annotation of GRCm38

  135603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8120  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DDAH1
Protein SuperFamily: N(G),N(G)-dimethylarginine dimethylaminohydrolase
Gene Tree: Ddah1

Human
homologs
DDAH1, dimethylarginine dimethylaminohydrolase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23576
neXtProt AC: NX_O94760

Human Synonyms: DDAH, HEL-S-16

Human Chr (Location): 1p22; chr1:85318485-85578363 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(5) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit lethality at E2. Mice heterozygous for a knock-out allele exhibit abnormal cardiovascular physiology. Mice with a conditional KO in endothelial cells have elevated blood pressure.
 
Interactions
Ddah1 interacts with 287 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process arginine metabolic process, citrulline metabolic process, ...
Component extracellular exosome, mitochondrion
Function amino acid binding, dimethylargininase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (173)    Tissues (136)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 170
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ddah1    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000029461 (Evidence)
Ensembl Gene Model ENSMUSG00000028194 (Evidence)
Entrez Gene 69219 (Evidence)
DFCI TC1655776, TC1579084
DoTS DT.101186081, DT.94266843
NIA Mouse Gene Index U003950
EC 3.5.3.18
Consensus CDS Project CCDS17896.1
International Mouse Phenotyping Consortium Status Ddah1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029461 VEGA Gene Model | MGI Sequence Detail 135603 C57BL/6J ±  kb
transcript OTTMUST00000073001 VEGA | MGI Sequence Detail 3764 Not Applicable 
polypeptide OTTMUSP00000037729 VEGA | MGI Sequence Detail 285 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(690 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003198 Amidinotransferase
Protein Ontology PR:000006338 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209681 Zhang P, et al., DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis. PLoS One. 2013;8(11):e79444
All references(50)
Other
accession IDs
MGI:1917484, MGI:2139846, MGI:2139962

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory