Ddah1 MGI Mouse Gene Detail - MGI:1916469 - dimethylarginine dimethylaminohydrolase 1

Ddah1 Gene Detail

Symbol

Ddah1
Name

dimethylarginine dimethylaminohydrolase 1
Synonyms

2410006N07Rik, 2510015N06Rik

Feature Type

protein coding gene
IDs

MGI:1916469
NCBI Gene: 69219
Alliance

gene page

Sequence Map

Chr3:145758675-145894277 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

135603 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 70.63 cM, cytoband H3
Mapping Data

3 experiments

Human Ortholog

DDAH1, dimethylarginine dimethylaminohydrolase 1

Vertebrate Orthologs

10

Human Ortholog

DDAH1, dimethylarginine dimethylaminohydrolase 1
Orthology source: HomoloGene, HGNC
Synonyms

DDAH, DDAH-1, DDAHI, HEL-S-16
Links

HGNC:2715

NCBI Gene ID: 23576

neXtProt AC: NX_O94760

UniProt: O94760
Chr Location

1p22.3; chr1:85318485-85578363 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8120
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DDAH1
Protein SuperFamily

N(G),N(G)-dimethylarginine dimethylaminohydrolase
Gene Tree

Ddah1

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References

1 with disease annotations

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Phenotype Summary

25 phenotypes from 6 alleles in 7 genetic backgrounds
8 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Gene trapped

4
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

1 involving Ddah1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Both heterozygous and homozygous inactivation of this gene leads to increased plasma asymmetrical dimethylarginine (ADMA) levels, reduced cardiovascular nitric oxide production, and increased blood pressure.

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All GO Annotations

21
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

173
Tissues

137
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddah1

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Ddah1 interacts with 287 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

40
RefSeq

6
UniProt

3
CCDS

CCDS17896.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000029461	VEGA Gene Model \| MGI Sequence Detail	135603	C57BL/6J	± kb
transcript	OTTMUST00000073001	VEGA \| MGI Sequence Detail	3764	Not Applicable
polypeptide	OTTMUSP00000037729	VEGA \| MGI Sequence Detail	285	Not Applicable

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SNPs within 2kb

683 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000006338 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

(term hierarchy)
EC

3.5.3.18
InterPro Domains

IPR033199 Dimethylarginine dimethylaminohydrolase/arginine deiminase

IPR033197 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

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All nucleic 15

cDNA 15

Microarray probesets 9

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MGI:1917484, MGI:2139846, MGI:2139962

Summaries

All 61

Developmental Gene Expression 5

Diseases 1

Gene Ontology 6

Phenotypes 29
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:234529 Dowsett L, et al., Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis. Circulation. 2015 Jun 23;131(25):2217-25

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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