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Srsf11 Gene Detail
Summary
  • Symbol
    Srsf11
  • Name
    serine and arginine-rich splicing factor 11
  • Synonyms
    0610009J05Rik, 2610019N13Rik, Sfrs11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916457
    NCBI Gene: 69207
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:157716552-157742304 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 81.63 cM, cytoband H4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    420 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916457
 protein coding gene Chr3:157716110-157742304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028015
 protein coding gene Chr3:162166863-162194841 (-)
A/J MGP_AJ_G0027973
 protein coding gene Chr3:156258405-156284640 (-)
AKR/J MGP_AKRJ_G0027939
 protein coding gene Chr3:160407295-160434646 (-)
BALB/cJ MGP_BALBcJ_G0027985
 protein coding gene Chr3:156071846-156098006 (-)
C3H/HeJ MGP_C3HHeJ_G0027715
 protein coding gene Chr3:160807439-160833679 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028428
 protein coding gene Chr3:167485114-167511592 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025767
 protein coding gene Chr3:150868684-150894612 (-)
CAST/EiJ MGP_CASTEiJ_G0027168
 protein coding gene Chr3:160950353-160979889 (-)
CBA/J MGP_CBAJ_G0027690
 protein coding gene Chr3:173429594-173458085 (-)
DBA/2J MGP_DBA2J_G0027830
 protein coding gene Chr3:155306200-155332415 (-)
FVB/NJ MGP_FVBNJ_G0027797
 protein coding gene Chr3:152656677-152682811 (-)
LP/J MGP_LPJ_G0027941
 protein coding gene Chr3:163495971-163525685 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027830
 protein coding gene Chr3:182016454-182043179 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028487
 protein coding gene Chr3:160087030-160113210 (-)
PWK/PhJ MGP_PWKPhJ_G0026891
 protein coding gene Chr3:155234199-155261495 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026719
 protein coding gene Chr3:158301321-158327464 (-)
WSB/EiJ MGP_WSBEiJ_G0027248
 protein coding gene Chr3:161050861-161077497 (-)



Homology
more
  • Human Ortholog
    SRSF11, serine and arginine rich splicing factor 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRSF11, serine and arginine rich splicing factor 11
  • Synonyms
    dJ677H15.2, NET2, p54, SFRS11
  • Links
    NCBI Gene ID: 9295
    UniProt: Q05519

  • Chr Location
    1p31.1; chr1:70205682-70253052 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    69
  • cDNA Data
    26
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69207 NCBI Gene Model | MGI Sequence Detail 25753 C57BL/6J ±  kb
    transcript NR_166757 RefSeq | MGI Sequence Detail 2986 C57BL/6  
    polypeptide NP_001366462 RefSeq | MGI Sequence Detail 483 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      19 Sequences
    • InterPro Domains
      IPR033489 E3 ubiquitin-protein ligase RBBP6 family
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR034447 Serine/arginine-rich splicing factor 11, RRM
    • GlyGen
      Q3UIX4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 26
      Primer pair 1
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1921339, MGI:2683641
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/24/2026
    MGI 6.24     		The Jackson Laboratory