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Snx5
Gene Detail
 Symbol
Name
ID
Snx5
sorting nexin 5
MGI:1916428
Synonyms 0910001N05Rik, 1810032P22Rik, D2Ertd52e
Feature Type protein coding gene
Genetic Map
Chromosome 2
70.98 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:144250123-144270906 bp, - strand
From VEGA annotation of GRCm38

  20784 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40944  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sorting nexin, Snx5/Snx6 types
Gene Tree: Snx5

Human
homologs
Human Homolog SNX5, sorting nexin 5
NCBI Gene ID 27131
neXtProt AC  NX_Q9Y5X3
Human Chr (Location)  20p11; chr20:17941596-17968991 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(41) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit impaired alveolar epithelial differentiation of type I cells, respiratory failure and lethality during the perinatal and postnatal periods.
 
Interactions
Snx5 interacts with 204 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process endocytosis, intracellular protein transport, ...
Component cell projection, cytoplasm, ...
Function lipid binding, phosphatidylinositol binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (353)    Tissues (87)    Images (38)
Theiler Stages: 11, 13, 19, 22, 23, 24, 28
Assay TypeResults
RNA in situ 353
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(29) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000003373 (Evidence)
Ensembl Gene ModelENSMUSG00000027423 (Evidence)
Entrez Gene69178 (Evidence)
DFCITC1573582, TC1601056
DoTSDT.101161441, DT.110735656, DT.110735703, DT.536707, DT.91302093, DT.94371727
NIA Mouse Gene IndexU023435
Consensus CDS ProjectCCDS16815.1
International Mouse Knockout Project StatusSnx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003373 VEGA Gene Model | MGI Sequence Detail 20784 C57BL/6J ±  kb
transcript OTTMUST00000007076 VEGA | MGI Sequence Detail 2512 Not Applicable 
polypeptide OTTMUSP00000003367 VEGA | MGI Sequence Detail 404 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001683 Phox homologous domain
InterPro IPR014637 Sorting nexin, Snx5/Snx6 types
InterPro IPR015404 Vps5 C-terminal
Protein Ontology PR:000015384 sorting nexin-5
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:199909 Im SK, et al., Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. PLoS One. 2013;8(3):e58511
All references(48)
Other
accession IDs
MGI:1098741, MGI:1915657, MGI:2139178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory