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Snx5
Gene Detail
Symbol

Name
ID
Snx5
sorting nexin 5
MGI:1916428
Synonyms
0910001N05Rik, 1810032P22Rik, D2Ertd52e
Feature Type
protein coding gene
Genetic Map
Chromosome 2
70.98 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:144250123-144270906 bp, - strand
From VEGA annotation of GRCm38

  20784 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40944  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SNX5
Protein SuperFamily: sorting nexin, Snx5/Snx6 types
Gene Tree: Snx5

Human
homologs
SNX5, sorting nexin 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 27131
neXtProt AC: NX_Q9Y5X3

Human Chr (Location): 20p11; chr20:17941596-17968991 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(41) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit impaired alveolar epithelial differentiation of type I cells, respiratory failure and lethality during the perinatal and postnatal periods.
 
Phenotype Images(4)
Interactions
Snx5 interacts with 203 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process endocytosis, intracellular protein transport, ...
Component cell projection, cytoplasm, ...
Function dynactin binding, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (353)    Tissues (87)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 353
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase snx5 ; ZFIN snx5    NEW 
Molecular
reagents
All nucleic(30) cDNA(29) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000003373 (Evidence)
Ensembl Gene Model ENSMUSG00000027423 (Evidence)
Entrez Gene 69178 (Evidence)
DFCI TC1573582, TC1601056
DoTS DT.101161441, DT.110735656, DT.110735703, DT.536707, DT.91302093, DT.94371727
NIA Mouse Gene Index U023435
Consensus CDS Project CCDS16815.1
International Mouse Phenotyping Consortium Status Snx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003373 VEGA Gene Model | MGI Sequence Detail 20784 C57BL/6J ±  kb
transcript OTTMUST00000007076 VEGA | MGI Sequence Detail 2512 Not Applicable 
polypeptide OTTMUSP00000003367 VEGA | MGI Sequence Detail 404 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001683 Phox homologous domain
InterPro IPR028654 Sorting nexin-5
InterPro IPR014637 Sorting nexin-5/6/32
InterPro IPR015404 Sorting nexin Vps5-like, C-terminal
Protein Ontology PR:000015384 sorting nexin-5
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:199909 Im SK, et al., Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. PLoS One. 2013;8(3):e58511
All references(47)
Other
accession IDs
MGI:1098741, MGI:1915657, MGI:2139178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory