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Fcmr Gene Detail
Summary
  • Symbol
    Fcmr
  • Name
    Fc fragment of IgM receptor
  • Synonyms
    1810037B05Rik, Faim3, FcmuR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916419
    NCBI Gene: 69169
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:130865777-130880790 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 56.89 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916419
protein coding gene Chr1:130865669-130880791 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016443
protein coding gene Chr1:134270063-134286463 (+)
A/J MGP_AJ_G0016426
protein coding gene Chr1:129300274-129315277 (+)
AKR/J MGP_AKRJ_G0016391
protein coding gene Chr1:133104678-133121861 (+)
BALB/cJ MGP_BALBcJ_G0016386
protein coding gene Chr1:129631440-129646766 (+)
C3H/HeJ MGP_C3HHeJ_G0016212
protein coding gene Chr1:133248167-133263117 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016847
protein coding gene Chr1:139267276-139282244 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014561
protein coding gene Chr1:122444873-122460118 (+)
CAST/EiJ MGP_CASTEiJ_G0015792
protein coding gene Chr1:132239422-132255364 (+)
CBA/J MGP_CBAJ_G0016184
protein coding gene Chr1:144069250-144084249 (+)
DBA/2J MGP_DBA2J_G0016291
protein coding gene Chr1:128262684-128277677 (+)
FVB/NJ MGP_FVBNJ_G0016290
protein coding gene Chr1:126905561-126922232 (+)
LP/J MGP_LPJ_G0016362
protein coding gene Chr1:135579417-135595674 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016315
protein coding gene Chr1:149830606-149847571 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016883
protein coding gene Chr1:132866911-132883050 (+)
PWK/PhJ MGP_PWKPhJ_G0015578
protein coding gene Chr1:127236062-127251099 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015365
protein coding gene Chr1:131805670-131823957 (+)
WSB/EiJ MGP_WSBEiJ_G0015854
protein coding gene Chr1:132841348-132856501 (+)



Homology
more
  • Human Ortholog
    FCMR, Fc fragment of IgM receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FCMR, Fc fragment of IgM receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAIM3, TOSO
  • Links
    NCBI Gene ID: 9214
    neXtProt AC: NX_O60667
    UniProt: O60667

  • Chr Location
    1q32.1; chr1:206903282-206922033 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Fcmr
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for knock-out alleles exhibit a slight decrease in B cell numbers reduced sensitivity to Gal-induced liver damage, increased granulocyte production of ROS and increased sensitivity to infection by Listeria monocytogenes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69169 NCBI Gene Model | MGI Sequence Detail 15014 C57BL/6J ±  kb
transcript NM_026976 RefSeq | MGI Sequence Detail 1491 C57BL/6  
polypeptide A1KXC4 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Gene Ontology 2
    Phenotypes 17
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:262882 Yu J, et al., Surface receptor Toso controls B cell-mediated regulation of T cell immunity. J Clin Invest. 2018 May 1;128(5):1820-1836

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory