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Ppp1r12b Gene Detail
Summary
  • Symbol
    Ppp1r12b
  • Name
    protein phosphatase 1, regulatory subunit 12B
  • Synonyms
    1810037O03Rik, 9530009M10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916417
    NCBI Gene: 329251
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134682396-134883680 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.24 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2061 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916417
protein coding gene Chr1:134682396-134883699 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016513
protein coding gene Chr1:138458174-138679525 (-)
A/J MGP_AJ_G0016496
protein coding gene Chr1:133233363-133441318 (-)
AKR/J MGP_AKRJ_G0016461
protein coding gene Chr1:137210726-137420449 (-)
BALB/cJ MGP_BALBcJ_G0016456
protein coding gene Chr1:133555656-133760150 (-)
C3H/HeJ MGP_C3HHeJ_G0016282
protein coding gene Chr1:137299733-137511651 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016917
protein coding gene Chr1:143484934-143703952 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014628
protein coding gene Chr1:126354680-126557454 (-)
CAST/EiJ MGP_CASTEiJ_G0015862
protein coding gene Chr1:136362215-136582985 (-)
CBA/J MGP_CBAJ_G0016255
protein coding gene Chr1:148430247-148653075 (-)
DBA/2J MGP_DBA2J_G0016361
protein coding gene Chr1:132237669-132447023 (-)
FVB/NJ MGP_FVBNJ_G0016360
protein coding gene Chr1:130875975-131082741 (-)
LP/J MGP_LPJ_G0016432
protein coding gene Chr1:139714665-139925367 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016385
protein coding gene Chr1:154131816-154356816 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016953
protein coding gene Chr1:136944833-137158959 (-)
PWK/PhJ MGP_PWKPhJ_G0015648
protein coding gene Chr1:131260872-131468789 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015435
protein coding gene Chr1:135908382-136126984 (-)
WSB/EiJ MGP_WSBEiJ_G0015925
protein coding gene Chr1:136971828-137188141 (-)



Homology
more
  • Human Ortholog
    PPP1R12B, protein phosphatase 1 regulatory subunit 12B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R12B, protein phosphatase 1 regulatory subunit 12B
  • Synonyms
    MYPT2, PP1bp55
  • Links
    NCBI Gene ID: 4660
    neXtProt AC: NX_O60237
    UniProt: O60237

  • Chr Location
    1q32.1; chr1:202348699-202592706 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073557 Ensembl Gene Model | MGI Sequence Detail 201285 C57BL/6J ±  kb
    transcript ENSMUST00000086444 Ensembl | MGI Sequence Detail 3137 Not Applicable  
    polypeptide ENSMUSP00000083633 Ensembl | MGI Sequence Detail 992 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013108 protein phosphatase 1 regulatory subunit 12B
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR031775 cGMP-dependent protein kinase, interacting domain
      IPR017401 Protein phosphatase 1 regulatory subunit 12A/B/C
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 15

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:2138164, MGI:2444883
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:335272 Hu T, et al., Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3. J Biol Chem. 2023 Apr;299(4):104584

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory