About   Help   FAQ
Rhebl1
Gene Detail
Symbol

Name
ID
Rhebl1
Ras homolog enriched in brain like 1
MGI:1916409
Synonyms
1810036J22Rik, Rheb2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
54.99 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:98877778-98881404 bp, - strand
From VEGA annotation of GRCm38

  3627 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: RHEBL1
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rhebl1

Human
homologs
RHEBL1, Ras homolog enriched in brain like 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 121268
neXtProt AC: NX_Q8TAI7

Human Synonyms: RHEBL1c

Human Chr (Location): 12q13.12; chr12:49064676-49070025 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(9) Radiation induced(1) Targeted(5)
Genomic Mutations involving Rhebl1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation are viable and fertile with no gross defects.
 
Phenotype Images(2)
Interactions
Rhebl1 interacts with 106 markers (Mir7-1, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process positive regulation of NF-kappaB transcription factor activity, signal transduction, ...
Component cytoplasm, membrane
Function GTP binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (73)    Tissues (14)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
RT-PCR 4
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rhebl1    NEW 
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024109 (Evidence)
Ensembl Gene Model ENSMUSG00000023755 (Evidence)
Entrez Gene 69159 (Evidence)
UniGene 259708
DFCI TC1584548
DoTS DT.97399282
NIA Mouse Gene Index U036636
Consensus CDS Project CCDS27809.1
International Mouse Phenotyping Consortium Status Rhebl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024109 VEGA Gene Model | MGI Sequence Detail 3627 C57BL/6J ±  kb
transcript OTTMUST00000058972 VEGA | MGI Sequence Detail 1185 Not Applicable 
polypeptide OTTMUSP00000028648 VEGA | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013976 GTPase RhebL1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213136 Baker MD, et al., The small GTPase Rheb is required for spermatogenesis but not oogenesis. Reproduction. 2014 May;147(5):615-25
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory