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Rhebl1
Gene Detail
Symbol

Name
ID
Rhebl1
Ras homolog enriched in brain like 1
MGI:1916409
Synonyms
1810036J22Rik, Rheb2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
54.99 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:98877778-98881404 bp, - strand
From VEGA annotation of GRCm38

  3627 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rhebl1

Human
homologs
Human Homolog RHEBL1, Ras homolog enriched in brain like 1
NCBI Gene ID 121268
neXtProt AC  NX_Q8TAI7
Human Synonyms  RHEBL1c
Human Chr (Location)  12q13.12; chr12:49064684-49070025 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(9) Radiation induced(1) Targeted(5)
Genomic Mutations involving Rhebl1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation are viable and fertile with no gross defects.
 
Interactions
Rhebl1 interacts with 106 markers (Mir7-1, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process GTP catabolic process, positive regulation of NF-kappaB transcription factor activity, ...
Component cytoplasm, membrane, ...
Function GTP binding, nucleotide binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (73)    Tissues (14)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
RT-PCR 4
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024109 (Evidence)
Ensembl Gene ModelENSMUSG00000023755 (Evidence)
Entrez Gene69159 (Evidence)
UniGene259708
DFCITC1584548
DoTSDT.97399282
NIA Mouse Gene IndexU036636
Consensus CDS ProjectCCDS27809.1
International Mouse Knockout Project StatusRhebl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024109 VEGA Gene Model | MGI Sequence Detail 3627 C57BL/6J ±  kb
transcript OTTMUST00000058972 VEGA | MGI Sequence Detail 1185 Not Applicable 
polypeptide OTTMUSP00000028648 VEGA | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013976 GTPase RhebL1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:168571 Zou J, et al., Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011 Jan 18;20(1):97-108
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory