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Comtd1 Gene Detail
Summary
  • Symbol
    Comtd1
  • Name
    catechol-O-methyltransferase domain containing 1
  • Synonyms
    1810030M08Rik, MT773
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916406
    NCBI Gene: 69156
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:21845861-21848910 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.92 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916406
protein coding gene Chr14:21845855-21848977 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021057
protein coding gene Chr14:14697462-14699255 (-)
A/J MGP_AJ_G0021006
protein coding gene Chr14:14309003-14310847 (-)
AKR/J MGP_AKRJ_G0020983
protein coding gene Chr14:14878632-14880347 (-)
BALB/cJ MGP_BALBcJ_G0021009
protein coding gene Chr14:14414989-14416834 (-)
C3H/HeJ MGP_C3HHeJ_G0020793
protein coding gene Chr14:14798254-14800098 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021442
protein coding gene Chr14:15175099-15176820 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019010
protein coding gene Chr14:14626118-14627956 (-)
CAST/EiJ MGP_CASTEiJ_G0020317
protein coding gene Chr14:14612980-14614845 (-)
CBA/J MGP_CBAJ_G0020759
protein coding gene Chr14:15959530-15961377 (-)
DBA/2J MGP_DBA2J_G0020882
protein coding gene Chr14:14141838-14143694 (-)
FVB/NJ MGP_FVBNJ_G0020865
protein coding gene Chr14:14029251-14031098 (-)
LP/J MGP_LPJ_G0020958
protein coding gene Chr14:14905011-14906773 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020891
protein coding gene Chr14:15702349-15704248 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021475
protein coding gene Chr14:14655982-14657880 (-)
PWK/PhJ MGP_PWKPhJ_G0020066
protein coding gene Chr14:13730888-13732776 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019888
protein coding gene Chr14:14469270-14472379 (-)
WSB/EiJ MGP_WSBEiJ_G0020373
protein coding gene Chr14:14653609-14657182 (-)



Homology
more
  • Human Ortholog
    COMTD1, catechol-O-methyltransferase domain containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COMTD1, catechol-O-methyltransferase domain containing 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 118881
    neXtProt AC: NX_Q86VU5
    UniProt: Q86VU5

  • Chr Location
    10q22.2; chr10:75233971-75236012 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69156 NCBI Gene Model | MGI Sequence Detail 3050 C57BL/6J ±  kb
transcript NM_026965 RefSeq | MGI Sequence Detail 2241 C57BL/6  
polypeptide Q8BIG7 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005732 catechol O-methyltransferase domain-containing protein 1
  • EC
  • InterPro Domains
    IPR002935 Class I-like SAM-dependent O-methyltransferase
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:237827 Gineste C, et al., In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscul Disord. 2013 Apr;23(4):357-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory