Ptgr2 MGI Mouse Gene Detail - MGI:1916372 - prostaglandin reductase 2

Symbol

Ptgr2
Name

prostaglandin reductase 2
Synonyms

1810016I24Rik, 9630002F03Rik, B830026H24Rik, PGR-2, Zadh1

Feature Type

protein coding gene
IDs

MGI:1916372
NCBI Gene: 77219
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:84332011-84362606 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.14 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

838 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916372	protein coding gene	Chr12:84332006-84362606 (+)
129S1/SvImJ	ENSMUSG00200046794	protein coding gene	Chr12:76346416-76377016 (+)
A/J	ENSMUSG00195029554	protein coding gene	Chr12:78965885-78996487 (+)
AKR/J	ENSMUSG00220045730	protein coding gene	Chr12:76761014-76791614 (+)
BALB/cJ	ENSMUSG00180020548	protein coding gene	Chr12:78003767-78034366 (+)
C3H/HeJ	ENSMUSG00175040107	protein coding gene	Chr12:81096858-81127454 (+)
C57BL/6NJ	ENSMUSG00215044040	protein coding gene	Chr12:77309349-77339949 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017937	protein coding gene	Chr12:78672931-78702786 (+)
CAST/EiJ	ENSTCUG00005025026	protein coding gene	Chr12:77278486-77309696 (+)
CBA/J	ENSMUSG00210036775	protein coding gene	Chr12:77510141-77540737 (+)
DBA/2J	ENSMUSG00185037635	protein coding gene	Chr12:79367088-79397688 (+)
FVB/NJ	ENSMUSG00205033158	protein coding gene	Chr12:77178758-77209357 (+)
JF1/MsJ	ENSUMUG00000039059	protein coding gene	Chr12:83362963-83394722 (+)
LP/J	ENSMUSG00230044577	protein coding gene	Chr12:86429653-86460241 (+)
NOD/ShiLtJ	ENSMUSG00190029464	protein coding gene	Chr12:76567104-76597704 (+)
NZO/HlLtJ	ENSMUSG00225050118	protein coding gene	Chr12:88467381-88497983 (+)
PWK/PhJ	ENSLUMG00010025253	protein coding gene	Chr12:77380265-77411230 (+)
SPRET/EiJ	ENSMSPG00010019068	protein coding gene	Chr12:79197316-79229041 (+)
WSB/EiJ	ENSIUOG00005037658	protein coding gene	Chr12:77196046-77226806 (+)

Human Ortholog

PTGR2, prostaglandin reductase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTGR2, prostaglandin reductase 2
Synonyms

HEL-S-298, PGR2, ZADH1
Links

HGNC:20149

NCBI Gene ID: 145482

UniProt: Q8N8N7
Chr Location

14q24.3; chr14:73851799-73885726 (+) GRCh38

MGI Vertebrate Homology

Ptgr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTGR2
Gene Tree

Ptgr2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

5
Targeted

1
Genomic Mutations

1 involving Ptgr2
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptgr2

ZFIN ptgr2

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All Sequences

73
RefSeq

10
UniProt

4
CCDS

CCDS36490.1

Ensembl

ENSMUSG00000072946 (Evidence)
NCBI Gene

77219

			Length	Strain/Species	Flank
genomic	77219	NCBI Gene Model \| MGI Sequence Detail	30596	C57BL/6J	± kb
transcript	NM_001252626	RefSeq \| MGI Sequence Detail	3250	C57BL/6
polypeptide	Q8VDQ1	UniProt \| EBI \| MGI Sequence Detail	351	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013426 prostaglandin reductase 2

(term hierarchy)
PDB

1VJ1, 2ZB3
EC

1.3.1.48
InterPro Domains

IPR013149 Alcohol dehydrogenase-like, C-terminal

IPR011032 GroES-like superfamily

IPR045010 Medium-chain dehydrogenase/reductase

IPR036291 NAD(P)-binding domain superfamily

IPR041694 Oxidoreductase, N-terminal domain

IPR037399 Prostaglandin reductase 2
GlyGen

Q8VDQ1 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 16

cDNA 16

Microarray probesets 8

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MGI:1924469, MGI:1926101, MGI:2144889

Summaries

All 45

Gene Ontology 11

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:185071 Yaguchi H, et al., TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis. J Biol Chem. 2012 Apr 6;287(15):12050-9

TSS for Ptgr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114333	Chr12:84332110-84332188 (+)	138 bp
Tssr114334	Chr12:84342993-84342996 (+)	10,984 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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