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Ubr4 Gene Detail
Summary
  • Symbol
    Ubr4
  • Name
    ubiquitin protein ligase E3 component n-recognin 4
  • Synonyms
    1810009A16Rik, A930005E13Rik, D930005K06Rik, LOC381562, mKIAA0462, p600, Zubr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916366
    NCBI Gene: 69116
  • Gene Overview
    MyGene.info: UBR4
Location & Maps
more
  • Sequence Map
    Chr4:139352609-139489588 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      136980 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.66 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    UBR4, ubiquitin protein ligase E3 component n-recognin 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBR4, ubiquitin protein ligase E3 component n-recognin 4
    Orthology source: HomoloGene
  • Synonyms
    p600, RBAF600, ZUBR1
  • Links
    NCBI Gene ID: 23352
    neXtProt AC: NX_Q5T4S7

  • Chr Location
    1p36.13; chr1:19074506-19210319 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10804
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: UBR4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 4 genetic backgrounds
    7 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    66
  • Chemically induced (other)
    2
  • Gene trapped
    56
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    3 involving Ubr4
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption exhibit neonatal lethality and decreased body size at birth. Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with arrest of vitelline vascular remodeling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009956 VEGA Gene Model | MGI Sequence Detail 136980 C57BL/6J ±  kb
transcript OTTMUST00000023125 VEGA | MGI Sequence Detail 15928 Not Applicable  
polypeptide OTTMUSP00000010547 VEGA | MGI Sequence Detail 5180 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    555 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 268
    cDNA 267
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2140710, MGI:2444481, MGI:2685878
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:211278 Belzil C, et al., p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex. Biol Open. 2014;3(6):475-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory