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Ubr4 Gene Detail
Summary
  • Symbol
    Ubr4
  • Name
    ubiquitin protein ligase E3 component n-recognin 4
  • Synonyms
    1810009A16Rik, A930005E13Rik, D930005K06Rik, LOC381562, mKIAA0462, p600, Zubr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916366
    NCBI Gene: 69116
  • Gene Overview
    MyGene.info: UBR4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:139380659-139489533 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    427 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916366
protein coding gene Chr4:139352609-139489588 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029018
protein coding gene Chr4:142184789-142325151 (+)
A/J MGP_AJ_G0028977
protein coding gene Chr4:136071341-136207668 (+)
AKR/J MGP_AKRJ_G0028929
protein coding gene Chr4:139970039-140114564 (+)
BALB/cJ MGP_BALBcJ_G0029001
protein coding gene Chr4:136743237-136884632 (+)
C3H/HeJ MGP_C3HHeJ_G0028715
protein coding gene Chr4:140348438-140492253 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029442
protein coding gene Chr4:147216205-147366394 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026713
protein coding gene Chr4:129026510-129162215 (+)
CAST/EiJ MGP_CASTEiJ_G0028147
protein coding gene Chr4:138533190-138681485 (+)
CBA/J MGP_CBAJ_G0028679
protein coding gene Chr4:151470106-151614396 (+)
DBA/2J MGP_DBA2J_G0028829
protein coding gene Chr4:136465639-136605261 (+)
FVB/NJ MGP_FVBNJ_G0028796
protein coding gene Chr4:135493423-135634774 (+)
LP/J MGP_LPJ_G0028928
protein coding gene Chr4:142258535-142399500 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028822
protein coding gene Chr4:155372847-155510948 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029480
protein coding gene Chr4:140498857-140637974 (+)
PWK/PhJ MGP_PWKPhJ_G0027868
protein coding gene Chr4:133315392-133454327 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027693
protein coding gene Chr4:136275579-136419121 (+)
WSB/EiJ MGP_WSBEiJ_G0028225
protein coding gene Chr4:140751580-140895744 (+)



Homology
more
  • Human Ortholog
    UBR4, ubiquitin protein ligase E3 component n-recognin 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBR4, ubiquitin protein ligase E3 component n-recognin 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p600, RBAF600, ZUBR1
  • Links
    NCBI Gene ID: 23352
    neXtProt AC: NX_Q5T4S7
    UniProt: Q5T4S7

  • Chr Location
    1p36.13; chr1:19074506-19210334 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10804
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UBR4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 4 genetic backgrounds
    7 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit neonatal lethality and decreased body size at birth. Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with arrest of vitelline vascular remodeling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69116 NCBI Gene Model | MGI Sequence Detail 108875 C57BL/6J ±  kb
    transcript NM_001160319 RefSeq | MGI Sequence Detail 15901 C57BL/6  
    polypeptide A2AN08 UniProt | EBI | MGI Sequence Detail 5180 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 269
      cDNA 268
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140710, MGI:2444481, MGI:2685878
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:265502 Kim ST, et al., The N-recognin UBR4 of the N-end rule pathway is required for neurogenesis and homeostasis of cell surface proteins. PLoS One. 2018;13(8):e0202260

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory