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Alkbh3 Gene Detail
Summary
  • Symbol
    Alkbh3
  • Name
    alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
  • Synonyms
    1700108H04Rik, 1810020C19Rik, Abh3, mABH3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916363
    NCBI Gene: 69113
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:93980624-94010823 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 51.62 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916363
protein coding gene Chr2:93980550-94010823 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026183
protein coding gene Chr2:95502668-95532897 (-)
A/J MGP_AJ_G0026144
protein coding gene Chr2:91617454-91648369 (-)
AKR/J MGP_AKRJ_G0026125
protein coding gene Chr2:94194903-94225110 (-)
BALB/cJ MGP_BALBcJ_G0026153
protein coding gene Chr2:91813734-91844439 (-)
C3H/HeJ MGP_C3HHeJ_G0025904
protein coding gene Chr2:94465744-94496746 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026604
protein coding gene Chr2:98752745-98782929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023995
protein coding gene Chr2:88097773-88128368 (-)
CAST/EiJ MGP_CASTEiJ_G0025369
protein coding gene Chr2:95068749-95101078 (-)
CBA/J MGP_CBAJ_G0025882
protein coding gene Chr2:102196690-102233655 (-)
DBA/2J MGP_DBA2J_G0026018
protein coding gene Chr2:91225381-91255615 (-)
FVB/NJ MGP_FVBNJ_G0025981
protein coding gene Chr2:90345326-90378251 (-)
LP/J MGP_LPJ_G0026122
protein coding gene Chr2:95693206-95727290 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026007
protein coding gene Chr2:105090903-105122048 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026658
protein coding gene Chr2:94268578-94300122 (-)
PWK/PhJ MGP_PWKPhJ_G0025104
protein coding gene Chr2:90976252-91006086 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024905
protein coding gene Chr2:93831190-93864461 (-)
WSB/EiJ MGP_WSBEiJ_G0025436
protein coding gene Chr2:94890509-94921310 (-)



Homology
more
  • Human Ortholog
    ALKBH3, alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ALKBH3, alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABH3, DEPC1, DEPC-1, hABH3, PCA1
  • Links
    NCBI Gene ID: 221120
    neXtProt AC: NX_Q96Q83
    UniProt: Q96Q83

  • Chr Location
    11p11.2; chr11:43880807-43920275 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    14 phenotype references
Mice homozygous for a knock-out allele exhibit a normal lifespan and are phenotypically indistinguishable from control littermates.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69113 NCBI Gene Model | MGI Sequence Detail 30200 C57BL/6J ±  kb
transcript NM_026944 RefSeq | MGI Sequence Detail 1247 Not Specified  
polypeptide Q8K1E6 UniProt | EBI | MGI Sequence Detail 286 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR032854 Alkylated DNA repair protein alkB homologue 3
    IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like
    IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
    IPR005123 Oxoglutarate/iron-dependent dioxygenase
Molecular
Reagents
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  • All nucleic 56
    cDNA 56

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920823
References
more
  • Summaries
    All 39
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:227263 Fabre PJ, et al., Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13964-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory