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Tmem176b Gene Detail
Summary
  • Symbol
    Tmem176b
  • Name
    transmembrane protein 176B
  • Synonyms
    1810009M01Rik, Clast1, Lr8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916348
    NCBI Gene: 65963
Location & Maps
more
  • Sequence Map
    Chr6:48833818-48841496 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7679 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 23.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TMEM176B, transmembrane protein 176B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TMEM176B, transmembrane protein 176B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LR8, MS4B2
  • Links
    NCBI Gene ID: 28959
    neXtProt AC: NX_Q3YBM2

  • Chr Location
    7q36.1; chr7:150791287-150801360 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
  • Incidental Mutations
    APF
Most mice homozygous for a knock-out allele exhibit severe sporadic ataxia and a small cerebellum associated with abnormal cerebellar lobulation, loss of the internal granule cell layer, poor formation of the external germinal layer, and disorganized Purkinje cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057390 VEGA Gene Model | MGI Sequence Detail 7679 C57BL/6J ±  kb
transcript OTTMUST00000141173 VEGA | MGI Sequence Detail 1414 Not Applicable  
polypeptide OTTMUSP00000073810 VEGA | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    68 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016418 transmembrane protein 176B
  • InterPro Domains
    IPR007237 CD20-like family
    IPR009281 Transmembrane protein 176A/B
Molecular
Reagents
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  • All nucleic 267
    Genomic 1
    cDNA 264
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 8
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:71873 Lurton J, et al., Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. Am J Respir Cell Mol Biol. 1999 Feb;20(2):327-31
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory