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Tmem176b
Gene Detail
Symbol

Name
ID
Tmem176b
transmembrane protein 176B
MGI:1916348
Synonyms
1810009M01Rik, Clast1, Lr8
Feature Type
protein coding gene
Genetic Map
Chromosome 6
23.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:48833811-48841374 bp, - strand
From Ensembl annotation of GRCm38

  7564 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8521  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tmem176b

Human
homologs
Human Homolog TMEM176B, transmembrane protein 176B
NCBI Gene ID 28959
neXtProt AC  NX_Q3YBM2
Human Synonyms  LR8
Human Chr (Location)  7q36.1; chr7:150791287-150801360 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Most mice homozygous for a knock-out allele exhibit severe sporadic ataxia and a small cerebellum associated with abnormal cerebellar lobulation, loss of the internal granule cell layer, poor formation of the external germinal layer, and disorganized Purkinje cells.
 
Interactions
Tmem176b interacts with 34 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell differentiation, negative regulation of dendritic cell differentiation
Component integral component of membrane, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (146)    Tissues (110)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 146
cDNA source data(264)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(267) Genomic(1) cDNA(264) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029810 (Evidence)
Entrez Gene65963 (Evidence)
UniGene28385
DFCITC1628710, TC1572972, TC1586024
DoTSDT.101275698, DT.97379269, DT.55258311, DT.101238323
NIA Mouse Gene IndexU027278
Consensus CDS ProjectCCDS20116.1
International Mouse Knockout Project StatusTmem176b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029810 Ensembl Gene Model | MGI Sequence Detail 7564 C57BL/6J ±  kb
transcript ENSMUST00000166247 Ensembl | MGI Sequence Detail 1421 Not Applicable 
polypeptide ENSMUSP00000131064 Ensembl | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(31) UniProt(1)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007237 CD20-like
InterPro IPR009281 LR8
Protein Ontology PR:000016418 transmembrane protein 176B
References
(Earliest) J:71873 Lurton J, et al., Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. Am J Respir Cell Mol Biol. 1999 Feb;20(2):327-31
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory