Sgsm3 MGI Mouse Gene Detail - MGI:1916329 - small G protein signaling modulator 3

Sgsm3 Gene Detail

Symbol

Sgsm3
Name

small G protein signaling modulator 3
Synonyms

1810012I01Rik, CIP85, Rutbc3

Feature Type

protein coding gene
IDs

MGI:1916329
NCBI Gene: 105835
Alliance

gene page

Sequence Map

Chr15:80977765-81012289 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

34525 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.96 cM
Mapping Data

2 experiments

Human Ortholog

SGSM3, small G protein signaling modulator 3

Vertebrate Orthologs

10

Human Ortholog

SGSM3, small G protein signaling modulator 3
Orthology source: HomoloGene, HGNC
Synonyms

CIP85, MAP, RabGAP-5, RABGAP5, rabGAPLP, RUSC3, RUTBC3
Links

HGNC:25228

NCBI Gene ID: 27352

neXtProt AC: NX_Q96HU1

UniProt: Q96HU1
Chr Location

22q13.1; chr22:40370530-40410289 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9249
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SGSM3
Gene Tree

Sgsm3

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References

1 with disease annotations

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Phenotype Summary

24 phenotype references

All Mutations and Alleles

19
Chemically induced (other)

1
Gene trapped

15
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Sgsm3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

21
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

109
Tissues

25
cDNA Data

90
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sgsm3

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Sgsm3 interacts with 85 markers (Mir24-1, Mir24-2, Mir26a-2, ...) View All

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All Sequences

91
RefSeq

18
UniProt

5
CCDS

CCDS49673.2
UniGene

274943

			Length	Strain/Species	Flank
genomic	OTTMUSG00000034072	VEGA Gene Model \| MGI Sequence Detail	34525	C57BL/6J	± kb
transcript	OTTMUST00000086075	VEGA \| MGI Sequence Detail	2996	Not Applicable
polypeptide	OTTMUSP00000046552	VEGA \| MGI Sequence Detail	750	Not Applicable

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SNPs within 2kb

113 from dbSNP Build 142

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UniProt

5 Sequences
PDB

2YUO
InterPro Domains

IPR000195 Rab-GTPase-TBC domain

IPR035969 Rab-GTPase-TBC domain superfamily

IPR004012 RUN domain

IPR037213 RUN domain superfamily

IPR035833 SGSM3, SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 92

cDNA 90

Primer pair 2

Microarray probesets 3

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MGI:2146003, MGI:2146266, MGI:2146321

Summaries

All 50

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 24
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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