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Adamts9 Gene Detail
Summary
  • Symbol
    Adamts9
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9
  • Synonyms
    1810011L16Rik, 8430403M15Rik, E030027K14Rik, Gsfund3, Mhdaund3, Mhdaund4, UND3, UND4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916320
    NCBI Gene: 101401
  • Gene Overview
    MyGene.info: ADAMTS9
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:92772699-92943492 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 41.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2021 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916320
protein coding gene Chr6:92772699-92944047 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031060
protein coding gene Chr6:94438518-94621108 (-)
A/J MGP_AJ_G0031029
protein coding gene Chr6:90847460-91022356 (-)
AKR/J MGP_AKRJ_G0030960
protein coding gene Chr6:93358508-93532922 (-)
BALB/cJ MGP_BALBcJ_G0031040
protein coding gene Chr6:90800883-90973521 (-)
C3H/HeJ MGP_C3HHeJ_G0030666
protein coding gene Chr6:90906100-91081659 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031499
protein coding gene Chr6:96860025-97039848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028666
protein coding gene Chr6:88817318-88993597 (-)
CAST/EiJ MGP_CASTEiJ_G0030147
protein coding gene Chr6:93494927-93677451 (-)
CBA/J MGP_CBAJ_G0030726
protein coding gene Chr6:100476948-100662302 (-)
DBA/2J MGP_DBA2J_G0030879
protein coding gene Chr6:90012586-90185002 (-)
FVB/NJ MGP_FVBNJ_G0030833
protein coding gene Chr6:89234905-89405299 (-)
LP/J MGP_LPJ_G0030959
protein coding gene Chr6:94397983-94572238 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030867
protein coding gene Chr6:104489561-104674895 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031526
protein coding gene Chr6:93215286-93391582 (-)
PWK/PhJ MGP_PWKPhJ_G0029863
protein coding gene Chr6:88990221-89163581 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029692
protein coding gene Chr6:92122437-92311767 (-)
WSB/EiJ MGP_WSBEiJ_G0030231
protein coding gene Chr6:93682397-93860971 (-)



Homology
more
  • Human Ortholog
    ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 56999
    neXtProt AC: NX_Q9P2N4
    UniProt: Q9P2N4

  • Chr Location
    3p14.1; chr3:64515654-64688000 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 8 alleles in 14 genetic backgrounds
    10 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality before somite formation. Mice heterozygous for a knock-out or ENU-induced allele exhibit a ring of epidermal hypopigmentation in the tail.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030022 Ensembl Gene Model | MGI Sequence Detail 170794 C57BL/6J ±  kb
    transcript ENSMUST00000113438 Ensembl | MGI Sequence Detail 8016 Not Applicable  
    polypeptide ENSMUSP00000109065 Ensembl | MGI Sequence Detail 1931 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR010294 ADAM-TS Spacer 1
      IPR024079 Metallopeptidase, catalytic domain superfamily
      IPR001590 Peptidase M12B, ADAM/reprolysin
      IPR012314 Peptidase M12B, GON-ADAMTSs
      IPR002870 Peptidase M12B, propeptide
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2141719, MGI:2442011, MGI:3530326, MGI:5629510
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 16
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:262498 Tharmarajah G, et al., Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase. Pigment Cell Melanoma Res. 2018 May 21;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory