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Slc30a5 Gene Detail
Summary
  • Symbol
    Slc30a5
  • Name
    solute carrier family 30 (zinc transporter), member 5
  • Synonyms
    1810010K08Rik, Znt5, ZnT-5, Zntl1, ZTL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916298
    NCBI Gene: 69048
Location & Maps
more
  • Sequence Map
    Chr13:100802649-100833427 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30779 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 53.23 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC30A5, solute carrier family 30 member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC30A5, solute carrier family 30 member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ZnT-5, ZNT5, ZNTL1, ZTL1
  • Links
    NCBI Gene ID: 64924
    neXtProt AC: NX_Q8TAD4

  • Chr Location
    5q12.1; chr5:69093949-69131072 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Gene trapped
    16
  • Targeted
    5
  • Incidental Mutations
Homozygous null mice are growth retarded and exhibit skeletal defects including reduced bone density. The majority of mutant male mice die suddenly when they reach reproductive age due to bradyarrhythmia, whereas female mice live a normal term.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021629 Ensembl Gene Model | MGI Sequence Detail 30779 C57BL/6J ±  kb
transcript ENSMUST00000067246 Ensembl | MGI Sequence Detail 3178 Not Applicable  
polypeptide ENSMUSP00000065764 Ensembl | MGI Sequence Detail 761 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015078 zinc transporter 5
  • InterPro Domains
    IPR002524 Cation efflux protein
    IPR027469 Cation efflux protein transmembrane domain
Molecular
Reagents
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  • All nucleic 107
    cDNA 106
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:2159353
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:76894 Lacourse KA, et al., Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol. 1999 May;276(5 Pt 1):G1302-9
  • Latest
    J:227247 Brommage R, et al., High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res. 2014;2:14034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory