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Sestd1 Gene Detail
Summary
  • Symbol
    Sestd1
  • Name
    SEC14 and spectrin domains 1
  • Synonyms
    1500031J16Rik, MGC:51459
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916262
    NCBI Gene: 228071
  • Gene Overview
    MyGene.info: SESTD1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:77180340-77280592 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 45.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    577 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916262
protein coding gene Chr2:77180340-77280592 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025872
protein coding gene Chr2:77610147-77705004 (-)
A/J MGP_AJ_G0025849
protein coding gene Chr2:74600640-74688672 (-)
AKR/J MGP_AKRJ_G0025818
protein coding gene Chr2:76587899-76692672 (-)
BALB/cJ MGP_BALBcJ_G0025844
protein coding gene Chr2:74766519-74876045 (-)
C3H/HeJ MGP_C3HHeJ_G0025604
protein coding gene Chr2:76803857-76897609 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026291
protein coding gene Chr2:79899538-80000069 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023694
protein coding gene Chr2:71993771-72090035 (-)
CAST/EiJ MGP_CASTEiJ_G0025066
protein coding gene Chr2:77139959-77259728 (-)
CBA/J MGP_CBAJ_G0025585
protein coding gene Chr2:82847721-82947569 (-)
DBA/2J MGP_DBA2J_G0025716
protein coding gene Chr2:74182687-74277161 (-)
FVB/NJ MGP_FVBNJ_G0025678
protein coding gene Chr2:73572879-73666448 (-)
LP/J MGP_LPJ_G0025804
protein coding gene Chr2:77493670-77589108 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025709
protein coding gene Chr2:84665995-84762914 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026347
protein coding gene Chr2:76719330-76817737 (-)
PWK/PhJ MGP_PWKPhJ_G0024809
protein coding gene Chr2:74144426-74247361 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024615
protein coding gene Chr2:76959814-77065375 (-)
WSB/EiJ MGP_WSBEiJ_G0025135
protein coding gene Chr2:77190731-77288229 (-)



Homology
more
  • Human Ortholog
    SESTD1, SEC14 and spectrin domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SESTD1, SEC14 and spectrin domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SOLO
  • Links
    NCBI Gene ID: 91404
    neXtProt AC: NX_Q86VW0
    UniProt: Q86VW0

  • Chr Location
    2q31.2; chr2:179101692-179264723 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 45505
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SESTD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, short and curly tail, absent genital tubercle, blind-end colon, hydronephrosis, absent bladder and more rounded posterior contour.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228071 NCBI Gene Model | MGI Sequence Detail 100253 C57BL/6J ±  kb
    transcript NM_175465 RefSeq | MGI Sequence Detail 8951 C57BL/6  
    polypeptide Q80UK0 UniProt | EBI | MGI Sequence Detail 696 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 77

      Microarray probesets 4
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:227263 Fabre PJ, et al., Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13964-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory