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Sestd1 Gene Detail
Summary
  • Symbol
    Sestd1
  • Name
    SEC14 and spectrin domains 1
  • Synonyms
    1500031J16Rik, MGC:51459
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916262
    NCBI Gene: 228071
  • Gene Overview
    MyGene.info: SESTD1
Location & Maps
more
  • Sequence Map
    Chr2:77180340-77280592 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      100253 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 45.92 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SESTD1, SEC14 and spectrin domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SESTD1, SEC14 and spectrin domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SOLO
  • Links
    NCBI Gene ID: 91404
    neXtProt AC: NX_Q86VW0

  • Chr Location
    2q31.2; chr2:179101692-179264623 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 45505
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SESTD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    15
  • Targeted
    5
  • Genomic Mutations
    3 involving Sestd1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit neonatal lethality, short and curly tail, absent genital tubercle, blind-end colon, hydronephrosis, absent bladder and more rounded posterior contour.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013223 VEGA Gene Model | MGI Sequence Detail 100253 C57BL/6J ±  kb
transcript OTTMUST00000031969 VEGA | MGI Sequence Detail 8990 Not Applicable  
polypeptide OTTMUSP00000014232 VEGA | MGI Sequence Detail 696 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    577 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 76
    cDNA 76

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:201925 Yang X, et al., SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) four-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic development in mice. J Biol Chem. 2013 Jul 12;288(28):20111-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory